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Gene Review

CD79B  -  CD79b molecule, immunoglobulin-associated...

Homo sapiens

Synonyms: AGM6, B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, B29, IGB, ...
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Disease relevance of CD79B

  • Expression of the Ig-associated heterodimer (mb-1 and B29) in Hodgkin's disease [1].
  • Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia [2].
  • B29 (CD79b) is present in the membrane at a later stage compared to its cytoplasmic expression and found in mature B blasts (B-ALL) that express membrane Ig as it is in normal and leukaemic B lymphocytes [3].
  • Jurkat T cells stably expressing micro, kappa, and mb1 efficiently assembled a functional BCR when infected with recombinant vaccinia virus bearing wild-type B29 [4].
  • The pattern of methylated CpG ((m)CpG) and C(m)C(A/T)GG B29 promoter methylation observed was similar to that recently reported for epigenetic silencing of an integrated retrovirus [5].

High impact information on CD79B

  • The Ig-alpha and Ig-beta proteins form a disulphide-linked alpha/beta heterodimer and are encoded by the mb-1 (ref 9, 10) and B29 genes, respectively [6].
  • However, some 20-40% of these B220(+)-CD19- cells also coexpress the NK1.1 surface molecule and do not express genes like VpreB or B29 restricted to the B cell lineage [7].
  • We found that efficient transport of IgM to the surface of T cells required coexpression of B29 [8].
  • The B29 and mb1 mutations appear at frequencies similar to those of other non-Ig genes but lower than Ig genes [9].
  • In contrast, B29 mutations displayed a bimodal distribution resembling the CD95Fas gene, in which promoter distal mutations conferred resistance to apoptosis [9].

Chemical compound and disease context of CD79B

  • First-pass hepatic extraction of insulin and hepatic and peripheral contributions to hypoglycemia were compared in conscious dogs during portal infusion of insulin A1, B29 diacetyl insulin, or A1-B29 dodecoyl insulin at 7 and 14 pmol X kg-1 X min-1 [10].

Biological context of CD79B

  • The transmembrane forms of all immunoglobulin (Ig) classes are associated with two glycoproteins, mb-1 and B29, that are crucial for signal transduction following antigen binding to the Ig molecule [11].
  • Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene [12].
  • Thus, the BCS may function as a tissue-specific LCR or position-dependent insulator specifically countering the influences of the 5' GH LCR and controlling B29 gene expression [13].
  • We searched available sequences upstream of the human, mouse, and rat B29 genes and found a highly conserved sequence that fulfills the criteria recently established for non-coding DNA elements potentially involved in gene control [13].
  • In the human and rat genomes, the B29 gene is located between the skeletal muscle-specific Na-channel alpha subunit (SCN4A) gene and the pituitary-specific growth hormone (GH-N) gene [13].

Anatomical context of CD79B

  • We have investigated the transcription and protein expression of mb-1 and B29 genes during B-cell development [11].
  • Transcription and protein expression of mb-1 and B29 genes in human hematopoietic malignancies and cell lines [11].
  • B29 transcripts were detectable in these cell samples, but low levels of B29 proteins were only detected in one plasma cell line [11].
  • B29 (CD79b) was expressed in the cytoplasm in 65% (15/23) of pre-B-ALL and in 14% (4/28) common-ALL but it was detected in the cell membrane in only three cases of mature B-ALL, being negative in all other B lineage subtypes ALL [3].
  • We conclude that association of the four components, Ig-heavy chain (HC) and -light chain (LC), MB-1 and B29, is required and sufficient to permit exit of the BCR complex out of the endoplasmic reticulum (ER) [14].

Associations of CD79B with chemical compounds

  • Using bisulfite genomic sequencing we found that in microdissected HRS cells of primary cHL SYK, BOB.1/OBF.1, and CD79B promoters were also hypermethylated [15].
  • 4. These results suggested that src-type tyrosine kinases as Fyn and Lyn are responsible for the phosphorylation of MB-1 and B29 heterodimer, but anti-MB-1 stimulation can induce tyrosine phosphorylation reaction mediated by other kinase molecule(s) in the progenitor type cells [16].
  • Formalin-fixed paraffin-embedded sections of equine and bovine lymph nodes, spleen, thymus, and Peyer's patches were incubated with monoclonal antibodies to B-lymphocyte markers BLA.36, B29, and mb-1 and T-lymphocyte markers CD3 and CD5 [17].
  • By using insulin that has been protected in positions A1 and B29, we have been able to couple the insulin selectively through the B1 amino group to divinyl sulfone-activated agarose [18].
  • Secretion of apoBs larger than B29 required the coexpression of MTP and, in the presence of MTP, was oleate-responsive [19].

Regulatory relationships of CD79B

  • This differential expression suggests that the B29 gene is insulated or otherwise protected from the regulatory influences of the closely proximal GH LCR [13].
  • These observations suggest that B-cell activation induces alternative splicing of mb-1 and B29 transcripts which encode proteins unable to constitute the BCR [20].

Other interactions of CD79B

  • CLL cells were identified by 4-color flow cytometric analysis of CD19/CD5/CD79b/CD20 expression in 910 outpatients over 40 years old [21].
  • The antigen-recognizing surface membrane-bound immunoglobulin (Ig) molecules on the surface of human and murine B cells are non-covalently associated with a heterodimeric protein complex of Ig-alpha (MB-1) and Ig-beta (B29) [22].
  • A flow cytometric assay was developed that can differentiate CLL cells from normal B cells on the basis of their CD19/CD5/CD20/CD79b expression [23].
  • Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking [24].

Analytical, diagnostic and therapeutic context of CD79B


  1. Expression of the Ig-associated heterodimer (mb-1 and B29) in Hodgkin's disease. Kuzu, I., Delsol, G., Jones, M., Gatter, K.C., Mason, D.Y. Histopathology (1993) [Pubmed]
  2. Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia. Thompson, A.A., Talley, J.A., Do, H.N., Kagan, H.L., Kunkel, L., Berenson, J., Cooper, M.D., Saxon, A., Wall, R. Blood (1997) [Pubmed]
  3. Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia. Astsaturov, I.A., Matutes, E., Morilla, R., Seon, B.K., Mason, D.Y., Farahat, N., Catovsky, D. Leukemia (1996) [Pubmed]
  4. Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells. Gordon, M.S., Kato, R.M., Lansigan, F., Thompson, A.A., Wall, R., Rawlings, D.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing. Malone, C.S., Miner, M.D., Doerr, J.R., Jackson, J.P., Jacobsen, S.E., Wall, R., Teitell, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Glycosyl-phosphatidylinositol linkage as a mechanism for cell-surface expression of immunoglobulin D. Wienands, J., Reth, M. Nature (1992) [Pubmed]
  7. A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. Rolink, A., ten Boekel, E., Melchers, F., Fearon, D.T., Krop, I., Andersson, J. J. Exp. Med. (1996) [Pubmed]
  8. Functional reconstitution of an immunoglobulin antigen receptor in T cells. Costa, T.E., Franke, R.R., Sanchez, M., Misulovin, Z., Nussenzweig, M.C. J. Exp. Med. (1992) [Pubmed]
  9. Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). Gordon, M.S., Kanegai, C.M., Doerr, J.R., Wall, R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. First-pass hepatic extraction and metabolic effects of insulin and insulin analogues. Chap, Z., Ishida, T., Chou, J., Hartley, C.J., Entman, M.L., Brandenburg, D., Jones, R.H., Field, J.B. Am. J. Physiol. (1987) [Pubmed]
  11. Transcription and protein expression of mb-1 and B29 genes in human hematopoietic malignancies and cell lines. Verschuren, M.C., Comans-Bitter, W.M., Kapteijn, C.A., Mason, D.Y., Brouns, G.S., Borst, J., Drexler, H.G., van Dongen, J.J. Leukemia (1993) [Pubmed]
  12. Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene. Bennani-Baïti, I.M., Cooke, N.E., Liebhaber, S.A. Genomics (1998) [Pubmed]
  13. A conserved sequence upstream of the B29 (Ig beta, CD79b) gene interacts with YY1. Patrone, L., Henson, S.E., Wall, R., Malone, C.S. Mol. Biol. Rep. (2004) [Pubmed]
  14. Assembly and intracellular transport of the human B cell antigen receptor complex. Brouns, G.S., de Vries, E., Borst, J. Int. Immunol. (1995) [Pubmed]
  15. Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma. Ushmorov, A., Leithäuser, F., Sakk, O., Weinhaüsel, A., Popov, S.W., Möller, P., Wirth, T. Blood (2006) [Pubmed]
  16. Induction of tyrosine phosphorylation in human B lineage cells by crosslinking MB-1 molecule of B cell receptor-related heterodimer complex. Kuwahara, K., Igarashi, H., Kawai, T., Ichigi, Y., Muraguchi, A., Mason, D.Y., Kimoto, M., Inui, S., Sakaguchi, N. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  17. Detection of equine and bovine T- and B-lymphocytes in formalin-fixed paraffin-embedded tissues. Kelley, L.C., Mahaffey, E.A., Bounous, D.I., Antczak, D.F., Brooks, R.L. Vet. Immunol. Immunopathol. (1997) [Pubmed]
  18. Immobilized insulin for high capacity affinity chromatography of insulin receptors. Markussen, J., Halstrøm, J., Wiberg, F.C., Schäffer, L. J. Biol. Chem. (1991) [Pubmed]
  19. Interactions between microsomal triglyceride transfer protein and apolipoprotein B within the endoplasmic reticulum in a heterologous expression system. Patel, S.B., Grundy, S.M. J. Biol. Chem. (1996) [Pubmed]
  20. The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing. Koyama, M., Nakamura, T., Higashihara, M., Herren, B., Kuwata, S., Shibata, Y., Okumura, K., Kurokawa, K. Immunol. Lett. (1995) [Pubmed]
  21. Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Rawstron, A.C., Green, M.J., Kuzmicki, A., Kennedy, B., Fenton, J.A., Evans, P.A., O'Connor, S.J., Richards, S.J., Morgan, G.J., Jack, A.S., Hillmen, P. Blood (2002) [Pubmed]
  22. Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29). Müller, B., Cooper, L., Terhorst, C. Immunol. Lett. (1995) [Pubmed]
  23. Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Rawstron, A.C., Kennedy, B., Evans, P.A., Davies, F.E., Richards, S.J., Haynes, A.P., Russell, N.H., Hale, G., Morgan, G.J., Jack, A.S., Hillmen, P. Blood (2001) [Pubmed]
  24. Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking. Hata, D., Nakamura, T., Kawakami, T., Kawakami, Y., Herren, B., Mayumi, M. Immunol. Lett. (1994) [Pubmed]
  25. B29 gene silencing in pituitary cells is regulated by its 3' enhancer. Malone, C.S., Kuraishy, A.I., Fike, F.M., Loya, R.G., Mikkili, M.R., Teitell, M.A., Wall, R. J. Mol. Biol. (2006) [Pubmed]
  26. Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB). Wood, W.J., Thompson, A.A., Korenberg, J., Chen, X.N., May, W., Wall, R., Denny, C.T. Genomics (1993) [Pubmed]
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