Gene Review:
Itk - IL2 inducible T cell kinase
Mus musculus
Synonyms:
Emt, IL-2-inducible T-cell kinase, Kinase EMT, Kinase TLK, T-cell-specific kinase, ...
- Identification of Itk/Tsk Src homology 3 domain ligands. Bunnell, S.C., Henry, P.A., Kolluri, R., Kirchhausen, T., Rickles, R.J., Berg, L.J. J. Biol. Chem. (1996)
- Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses. Forssell, J., Sideras, P., Eriksson, C., Malm-Erjefält, M., Rydell-Törmänen, K., Ericsson, P.O., Erjefält, J.S. Am. J. Respir. Cell Mol. Biol. (2005)
- Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. Dombroski, D., Houghtling, R.A., Labno, C.M., Precht, P., Takesono, A., Caplen, N.J., Billadeau, D.D., Wange, R.L., Burkhardt, J.K., Schwartzberg, P.L. J. Immunol. (2005)
- Antiviral immune responses in Itk-deficient mice. Bachmann, M.F., Littman, D.R., Liao, X.C. J. Virol. (1997)
- Tec family kinases in T lymphocyte development and function. Berg, L.J., Finkelstein, L.D., Lucas, J.A., Schwartzberg, P.L. Annu. Rev. Immunol. (2005)
- Regulatory intramolecular association in a tyrosine kinase of the Tec family. Andreotti, A.H., Bunnell, S.C., Feng, S., Berg, L.J., Schreiber, S.L. Nature (1997)
- Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Broussard, C., Fleischecker, C., Horai, R., Chetana, M., Venegas, A.M., Sharp, L.L., Hedrick, S.M., Fowlkes, B.J., Schwartzberg, P.L. Immunity (2006)
- The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Atherly, L.O., Lucas, J.A., Felices, M., Yin, C.C., Reiner, S.L., Berg, L.J. Immunity (2006)
- Itk and Fyn make independent contributions to T cell activation. Liao, X.C., Littman, D.R., Weiss, A. J. Exp. Med. (1997)
- Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help. Atherly, L.O., Brehm, M.A., Welsh, R.M., Berg, L.J. J. Immunol. (2006)
- The role of Tec family kinases in T cell development and function. Lucas, J.A., Miller, A.T., Atherly, L.O., Berg, L.J. Immunol. Rev. (2003)
- Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk. Laederach, A., Cradic, K.W., Fulton, D.B., Andreotti, A.H. J. Mol. Biol. (2003)
- Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. Hata, D., Kawakami, Y., Inagaki, N., Lantz, C.S., Kitamura, T., Khan, W.N., Maeda-Yamamoto, M., Miura, T., Han, W., Hartman, S.E., Yao, L., Nagai, H., Goldfeld, A.E., Alt, F.W., Galli, S.J., Witte, O.N., Kawakami, T. J. Exp. Med. (1998)
- Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases? Cannons, J.L., Schwartzberg, P.L. Curr. Opin. Immunol. (2004)
- Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells. Kawakami, Y., Yao, L., Tashiro, M., Gibson, S., Mills, G.B., Kawakami, T. J. Immunol. (1995)
- Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Miller, A.T., Wilcox, H.M., Lai, Z., Berg, L.J. Immunity (2004)
- Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Liao, X.C., Littman, D.R. Immunity (1995)
- A key role for Itk in both IFN gamma and IL-4 production by NKT cells. Au-Yeung, B.B., Fowell, D.J. J. Immunol. (2007)
- Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Colgan, J., Asmal, M., Neagu, M., Yu, B., Schneidkraut, J., Lee, Y., Sokolskaja, E., Andreotti, A., Luban, J. Immunity (2004)
- The absence of Itk inhibits positive selection without changing lineage commitment. Lucas, J.A., Atherly, L.O., Berg, L.J. J. Immunol. (2002)
- The role of Tec protein-tyrosine kinase in T cell signaling. Yang, W.C., Ghiotto, M., Barbarat, B., Olive, D. J. Biol. Chem. (1999)
- Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion. Finkelstein, L.D., Shimizu, Y., Schwartzberg, P.L. J. Immunol. (2005)
- Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. Miller, A.T., Berg, L.J. J. Immunol. (2002)
- Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. Hu, Q., Davidson, D., Schwartzberg, P.L., Macchiarini, F., Lenardo, M.J., Bluestone, J.A., Matis, L.A. J. Biol. Chem. (1995)
- Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Labno, C.M., Lewis, C.M., You, D., Leung, D.W., Takesono, A., Kamberos, N., Seth, A., Finkelstein, L.D., Rosen, M.K., Schwartzberg, P.L., Burkhardt, J.K. Curr. Biol. (2003)
- Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q. Janis, E.M., Siliciano, J.D., Isaac, D.D., Griffin, C.A., Hawkins, A.L., Kozak, C.A., Desiderio, S. Genomics (1994)
- Localization of the human IL-2-inducible T-cell kinase gene (ITK) to chromosome band 5q34 and the mouse gene (Itk) to chromosome 15 by fluorescence in situ hybridization. Tate, G., Okuyama, M., Okamoto, M., Futaki, G., Kimura, S., Endo, Y., Mitsuya, T., Katagiri, M. Cytogenet. Cell Genet. (1996)
- Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy. Donnadieu, E., Lang, V., Bismuth, G., Ellmeier, W., Acuto, O., Michel, F., Trautmann, A. J. Immunol. (2001)