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Gene Review

Icam2  -  intercellular adhesion molecule 2

Mus musculus

Synonyms: CD102, ICAM-2, Icam-2, Intercellular adhesion molecule 2, Ly-60, ...
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Disease relevance of Icam2


High impact information on Icam2


Biological context of Icam2


Anatomical context of Icam2

  • Intercellular adhesion molecule-2 (ICAM-2), a cell surface glycoprotein, is a second counter-receptor for lymphocyte function-associated Ag-1 (LFA-1) [7].
  • COS cells transfected with the ICAM-2 cDNA do not react with mAb PA3, previously suggested to define ICAM-2 in the mouse [7].
  • ICAM-2 provides a costimulatory signal for T cell stimulation by allogeneic class II MHC [9].
  • We demonstrate that blocking the interactions between lymphocyte function associated (LFA)-1 and intercellular adhesion molecule(ICAM)-1 and ICAM-2 completely suppresses Fas-dependent B cell lysis [11].
  • ICAM-1 and ICAM-2 are both expressed on endothelium and serve as counterreceptors during lymphocyte trafficking [12].

Associations of Icam2 with chemical compounds


Regulatory relationships of Icam2

  • Under these suboptimal TCR stimulation conditions, ICAM-2 could also enhance the recruitment of signaling molecules in Itk-/-, but not Rlk-/-Itk-/- T cells [16].
  • Stimulation with ICAM-2 in conjunction with anti-TCR-coated beads enhanced polarization of Vav1, protein kinase Ctheta, and Pyk2 in wild-type cells, demonstrating a role for integrins in potentiating the recruitment of signaling molecules in T cells [16].
  • Both neuro-2a/LN and neuro-2a/ICAM-1+ lines expressed ICAM-2 (MCF = 16.4 and 16.5) [17].

Other interactions of Icam2

  • RESULTS: Basal values of PECAM-1 and ICAM-2 revealed a low vascular density in the implanted sponge matrices that is comparable to skin [18].
  • The HYKO6 cell line exhibited endothelial characteristics, such as constitutive expression of CD105, CD31, ICAM-2, VCAM-1, and von Willebrand factor and formation of capillary-like structures (CLS) on Matrigel surface [19].
  • The leukocyte adhesion molecule intercellular adhesion molecule 2 (ICAM-2) is expressed at the endothelial junctions [20].
  • Here we show that cross-linking of part of the LFA-1 molecules with Abs causes activation of free LFA-1 molecules (not occupied by the Ab) on the same cell, which then bind to ICAM-2 on other cells [21].
  • Expression of intercellular adhesion molecule-1 (ICAM-1), ICAM-2-like molecule (Lgp55), and class I/II major histocompatibility complex (MHC) antigens (H-2 and Ia) was investigated in cultures of murine oligodendrocytes and astrocytes [22].

Analytical, diagnostic and therapeutic context of Icam2

  • To test this hypothesis, ICAM-2 expression was first examined in both uninfected and P. aeruginosa-infected eyes (6 h postinfection) by immunohistochemistry and RT-PCR [2].
  • Endothelial intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 are both involved in lymphocyte extravasation during immunosurveillance and inflammation [23].
  • ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma [24].
  • This conservation of function across the species barrier suggests that pig ICAM-2 plays a role in the cellular interactions associated with xenograft rejection [25].
  • Only anti-CTLA-4 (CD152) mAb has entered clinical trials, but the preclinical effects described for anti-CD40, anti-CD137 (4-1BB), anti-CD102 (intercellular adhesion molecule-2), and regulatory T cell-depleting mAbs should lead to their prompt clinical development [26].


  1. Characterization of murine intercellular adhesion molecule-2. Xu, H., Bickford, J.K., Luther, E., Carpenito, C., Takei, F., Springer, T.A. J. Immunol. (1996) [Pubmed]
  2. Intercellular adhesion molecule-2 (ICAM-2) and Pseudomonas aeruginosa ocular infection. Hobden, J.A. DNA Cell Biol. (2003) [Pubmed]
  3. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Gerwin, N., Gonzalo, J.A., Lloyd, C., Coyle, A.J., Reiss, Y., Banu, N., Wang, B., Xu, H., Avraham, H., Engelhardt, B., Springer, T.A., Gutierrez-Ramos, J.C. Immunity (1999) [Pubmed]
  4. ICAM-2 redistributed by ezrin as a target for killer cells. Helander, T.S., Carpén, O., Turunen, O., Kovanen, P.E., Vaheri, A., Timonen, T. Nature (1996) [Pubmed]
  5. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. Vazeux, R., Hoffman, P.A., Tomita, J.K., Dickinson, E.S., Jasman, R.L., St John, T., Gallatin, W.M. Nature (1992) [Pubmed]
  6. Activation of the PKB/AKT pathway by ICAM-2. Perez, O.D., Kinoshita, S., Hitoshi, Y., Payan, D.G., Kitamura, T., Nolan, G.P., Lorens, J.B. Immunity (2002) [Pubmed]
  7. Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA. Xu, H., Tong, I.L., De Fougerolles, A.R., Springer, T.A. J. Immunol. (1992) [Pubmed]
  8. The alymphoplasia (aly) mutation co-segregates with the intercellular adhesion molecule-2 (lcam-2) on mouse chromosome 11. Kuramoto, T., Mashimo, T., Koike, R., Miyawaki, S., Yamada, J., Miyasaka, M., Serikawa, T. Int. Immunol. (1994) [Pubmed]
  9. ICAM-2 provides a costimulatory signal for T cell stimulation by allogeneic class II MHC. Carpenito, C., Pyszniak, A.M., Takei, F. Scand. J. Immunol. (1997) [Pubmed]
  10. Interferon-gamma- and phorbol myristate acetate-responsive elements involved in intercellular adhesion molecule-1 mRNA stabilization. Ohh, M., Takei, F. J. Biol. Chem. (1994) [Pubmed]
  11. Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95. Wang, J., Lenardo, M.J. J. Exp. Med. (1997) [Pubmed]
  12. Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. Lehmann, J.C., Jablonski-Westrich, D., Haubold, U., Gutierrez-Ramos, J.C., Springer, T., Hamann, A. J. Immunol. (2003) [Pubmed]
  13. A peptide from ICAM-2 binds to the leukocyte integrin CD11a/CD18 and inhibits endothelial cell adhesion. Li, R., Nortamo, P., Valmu, L., Tolvanen, M., Huuskonen, J., Kantor, C., Gahmberg, C.G. J. Biol. Chem. (1993) [Pubmed]
  14. Sporozoites of Plasmodium yoelii infect mice with targeted deletions in ICAM-1 and ICAM-2 or complement components C3 and C4. Sultan, A.A., Briones, M.R., Gerwin, N., Carroll, M.C., Nussenzweig, V. Mol. Biochem. Parasitol. (1997) [Pubmed]
  15. {alpha}-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation. Fagerholm, S.C., Varis, M., Stefanidakis, M., Hilden, T.J., Gahmberg, C.G. Blood (2006) [Pubmed]
  16. Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion. Finkelstein, L.D., Shimizu, Y., Schwartzberg, P.L. J. Immunol. (2005) [Pubmed]
  17. Transfection of the mouse ICAM-1 gene into murine neuroblastoma enhances susceptibility to lysis, reduces in vivo tumorigenicity and decreases ICAM-2-dependent killing. Katsanis, E., Bausero, M.A., Xu, H., Orchard, P.J., Xu, Z., McIvor, R.S., Brian, A.A., Blazar, B.R. Cancer Immunol. Immunother. (1994) [Pubmed]
  18. Expression of endothelial cell adhesion molecules in neovascularized tissue. Vallien, G., Langley, R., Jennings, S., Specian, R., Granger, D.N. Microcirculation (New York, N.Y. : 1994) (2000) [Pubmed]
  19. Establishment of an immortalized PARP-1-/- murine endothelial cell line: a new tool to study PARP-1 mediated endothelial cell dysfunction. Carrillo, A., Monreal, Y., Ramirez, P., Suarez, E., Parrilla, P., Menissier-de Murcia, J., de Murcia, G., Alvarez-Vallina, L., Yélamos, J. J. Cell. Biochem. (2005) [Pubmed]
  20. Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis. Huang, M.T., Mason, J.C., Birdsey, G.M., Amsellem, V., Gerwin, N., Haskard, D.O., Ridley, A.J., Randi, A.M. Blood (2005) [Pubmed]
  21. LFA-1 to LFA-1 signals involve zeta-associated protein-70 (ZAP-70) tyrosine kinase: relevance for invasion and migration of a T cell hybridoma. Soede, R.D., Driessens, M.H., Ruuls-Van Stalle, L., Van Hulten, P.E., Brink, A., Roos, E. J. Immunol. (1999) [Pubmed]
  22. Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murine oligodendrocytes and astrocytes. Satoh, J., Kim, S.U., Kastrukoff, L.F., Takei, F. J. Neurosci. Res. (1991) [Pubmed]
  23. T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. Lyck, R., Reiss, Y., Gerwin, N., Greenwood, J., Adamson, P., Engelhardt, B. Blood (2003) [Pubmed]
  24. ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma. Tanaka, H., Yashiro, M., Sunami, T., Sakate, Y., Kosaka, K., Hirakawa, K. Clin. Cancer Res. (2004) [Pubmed]
  25. Characterization of pig intercellular adhesion molecule-2 and its interaction with human LFA-1. Godwin, J.W., d'Apice, A.J., Cowan, P.J. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2004) [Pubmed]
  26. Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies. Murillo, O., Arina, A., Tirapu, I., Alfaro, C., Mazzolini, G., Palencia, B., López-Diaz De Cerio, A., Prieto, J., Bendandi, M., Melero, I. Clin. Cancer Res. (2003) [Pubmed]
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