Disease relevance of MAS1

• The Mas1 transgenic mice may be useful in understanding the cone photoreceptor degeneration that occurs in cone dystrophies and age-related macular degeneration and in evaluating potential therapies for these disorders [1].
• The majority of ATLL cells bear Leu-1 and Leu-3a antigen on cell surface but lack Leu-2a antigen and were unreactive with MAS 036 c. These results indicate that ATLL cells are of peripheral inducer/helper T-cell origin [2].
• The peripheral blood lymphocytes from eight healthy volunteers produced significant amounts of interferon (IFN) when co-cultured with a recently discovered mitogen preparation derived from cultures of Mycoplasma arthritidis (MAS) [3].
• High resolution magic angle spinning (HR-MAS) NMR was used to examine capsular polysaccharides directly from campylobacter cells and showed profiles similar to those observed for purified polysaccharides analyzed by solution NMR [4].
• Low-temperature 15N and 13C CP/MAS (cross-polarization/magic angle spinning) NMR has been used to analyze BChl-histidine interactions and the electronic structure of histidine residues in the light-harvesting complex II (LH2) of Rhodopseudomonas acidophila [5].

Psychiatry related information on MAS1

• OBJECTIVE: To evaluate the short-term tolerability of an extended-release preparation of the stimulant medication mixed amphetamine salts (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD) whose hypertension has been successfully treated with antihypertensive medications [6].
• The MAS implied improved diagnostic reliability of mental retardation, somatic disorders and developmental disorders [7].
• Objective: Assess cardiovascular effects of mixed amphetamine salts extended release (MAS XR) in children and adolescents (6-17 years of age) with oppositional defiant disorder (ODD) [8].
• Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy [9].
• The multiaxial system (MAS) of ICD-10, chapter V (F) consists of three axes: axis I, clinical syndromes (psychiatric disorders including personality disorders and somatic diseases); axis II, disabilities; axis III, environmental/circumstantial and personal life-style/life management factors [10].

High impact information on MAS1

• Southern analysis demonstrated that only one copy of three proto-oncogene loci (ros1, c-myb, and mas1) on 6q was retained in immortal cells [11].
• The majority of the leukemic cells of these patients were reactive with anti-Leu-1 and anti-Leu-3a, but unreactive with anti-Leu-2a and MAS 036c monoclonal antibodies at the time of initial diagnosis, indicating that ATL cells are of peripheral inducer/helper T cell origin [12].
• Surface phenotypes of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma (ATLL) were analyzed by using monoclonal antibodies (anti-Leu-1, anti-Leu-2a, anti-Leu-3a, anti-HLA-DR and MAS 036 c), and the effect of leukemic cells on PWM-induced normal B-cell differentiation was also studied [2].
• Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS [13].
• These data demonstrate that the ability of MAS to up-regulate AT(1) receptor levels reflects the constitutive capacity of MAS to activate Galpha(q)/Galpha(11) and hence stimulate PKC-dependent phosphorylation of the AT(1) receptor [13].

Chemical compound and disease context of MAS1

• In addition, HR-MAS NMR detected the N-linked glycan, GalNAc-alpha1,4-GalNAc-alpha1,4-[Glc-beta1,3-]GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac, where Bac is 2,4-diacetamido-2,4,6-trideoxy-d-glucopyranose, in C. jejuni and Campylobacter coli [4].
• OBJECTIVE: To evaluate the long-term tolerability and effectiveness of extended-release mixed amphetamine salts (MAS XR; Adderall XR) in children with attention-deficit/hyperactivity disorder (ADHD) [14].
• A 31P CP/MAS NMR study on dehydration of disodium clodronate tetrahydrate [15].
• The lymphoproliferation (LP) test was performed with one bacterial recall antigen (PPD) and four different mitogens (phytohemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and a novel mitogen derived from mycoplasma arthritidis - MAS) [16].
• In this study HR MAS spectra of breast cancer tissue from 10 patients have been compared to conventional high-resolution spectra of perchloric acid extracts of the same tissue type [17].

Biological context of MAS1

• To evaluate the cellular and functional changes induced in cone photoreceptors by an oncogene, the Mas1 protooncogene was targeted to the cones of transgenic mice by the human red/green opsin promoter [1].
• The mammalian proto-oncogene MAS has been identified as a novel neuronal angiotensin receptor, which responds preferentially to Ang III, and has other unusual pharmacological properties [18].
• The time course of AT(1) receptor-CFP up-regulation was also markedly slower than that of induction of MAS expression [13].
• The presence of this common heptasaccharide in multiple campylobacter isolates demonstrates the conservation of the N-linked protein glycosylation pathway in this organism and describes the first report of HR-MAS NMR detection of N-linked glycans on glycoproteins from intact bacterial cells [4].
• Kinetics and mechanism of the beta- to alpha-CuAlCl(4) phase transition: a time-resolved (63)Cu MAS NMR and powder X-ray diffraction study [19].

Anatomical context of MAS1

• Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene [1].
• By making use of a novel intragenic polymorphism, we have studied the expression of the MAS gene in three heterozygous human fetuses [20].
• Cell type-specific expression of the Mas proto-oncogene in testis [21].
• These and other studies suggest that the cellular requirement for T cell activation by MAS, PHA, and Con A may all be distinct [3].
• Anti-HLA.DR-mediated inhibition of lymphocyte functions, however, was not specific for MAS inasmuch as viral-induced IFN was also suppressed, as was Con A-induced proliferation [3].

Associations of MAS1 with chemical compounds

• The understanding of the MAS/angiotensin receptor may compel a basic rethinking of many aspects of the cardiovascular biology of the renin-angiotensin system [18].
• HR-MAS NMR examination of growth from individual colonies of C. jejuni NCTC11168 indicated that the capsular glycan modifications are also phase-variable [4].
• To study chiral recognition phenomena in the presence of the CSP, (1)H HR/MAS 2D transfer NOESY investigations in methanol-d(4) have been undertaken with various solutes including N-3,5-dinitrobenzoyl derivatives of leucine (DNB-Leu) and N-acetyl phenylalanine (Ac-Phe) [22].
• 19F MAS NMR quantification of accessible hydroxyl sites on fiberglass surfaces [23].
• Lanosterol 14alpha-demethylase (CYP51) produces MAS sterols, intermediates in cholesterol biosynthesis that can reinitiate meiosis in mouse oocytes [24].

Other interactions of MAS1

• Hence both MAS and the neighboring IGF2R gene are not imprinted in humans [20].

Analytical, diagnostic and therapeutic context of MAS1

• The materials have been characterized by SEM, TEM, XRD, (13)C NMR MAS, XPS, FTIR spectroscopy, and BET surface area measurements [25].
• Nitrogen adsorption provided strong evidence of the presence of uniformly sized pores and the lack of phase separation up to TEVS:TEOS ratios as high as 13:7 (65% TEVS loading), whereas (29)Si MAS NMR and high-resolution thermogravimetry showed essentially quantitative incorporation of the organosilane [26].
• The structure of these solids was elucidated by single-crystal (180 K) and powder X-ray diffraction and further characterized by chemical analysis, thermogravimetry, scanning electron microscopy, (29)Si MAS NMR, and photoluminescence spectroscopy [27].
• The materials are characterized by a variety of spectroscopic ((13)C and (29)Si CP MAS NMR, X-ray diffraction) and quantitative (TGA/DTA, elemental analysis, acid capacity titration) techniques [28].
• The presence of molecularly ordered ethylene groups was confirmed by powder X-ray diffraction, (29)Si and (13)C MAS NMR, and Raman spectroscopy [29].

References