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Gene Review

MAS1  -  MAS1 proto-oncogene, G protein-coupled...

Homo sapiens

Synonyms: MAS, MGRA, Proto-oncogene Mas
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Disease relevance of MAS1

  • The Mas1 transgenic mice may be useful in understanding the cone photoreceptor degeneration that occurs in cone dystrophies and age-related macular degeneration and in evaluating potential therapies for these disorders [1].
  • The majority of ATLL cells bear Leu-1 and Leu-3a antigen on cell surface but lack Leu-2a antigen and were unreactive with MAS 036 c. These results indicate that ATLL cells are of peripheral inducer/helper T-cell origin [2].
  • The peripheral blood lymphocytes from eight healthy volunteers produced significant amounts of interferon (IFN) when co-cultured with a recently discovered mitogen preparation derived from cultures of Mycoplasma arthritidis (MAS) [3].
  • High resolution magic angle spinning (HR-MAS) NMR was used to examine capsular polysaccharides directly from campylobacter cells and showed profiles similar to those observed for purified polysaccharides analyzed by solution NMR [4].
  • Low-temperature 15N and 13C CP/MAS (cross-polarization/magic angle spinning) NMR has been used to analyze BChl-histidine interactions and the electronic structure of histidine residues in the light-harvesting complex II (LH2) of Rhodopseudomonas acidophila [5].

Psychiatry related information on MAS1


High impact information on MAS1

  • Southern analysis demonstrated that only one copy of three proto-oncogene loci (ros1, c-myb, and mas1) on 6q was retained in immortal cells [11].
  • The majority of the leukemic cells of these patients were reactive with anti-Leu-1 and anti-Leu-3a, but unreactive with anti-Leu-2a and MAS 036c monoclonal antibodies at the time of initial diagnosis, indicating that ATL cells are of peripheral inducer/helper T cell origin [12].
  • Surface phenotypes of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma (ATLL) were analyzed by using monoclonal antibodies (anti-Leu-1, anti-Leu-2a, anti-Leu-3a, anti-HLA-DR and MAS 036 c), and the effect of leukemic cells on PWM-induced normal B-cell differentiation was also studied [2].
  • Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS [13].
  • These data demonstrate that the ability of MAS to up-regulate AT(1) receptor levels reflects the constitutive capacity of MAS to activate Galpha(q)/Galpha(11) and hence stimulate PKC-dependent phosphorylation of the AT(1) receptor [13].

Chemical compound and disease context of MAS1

  • In addition, HR-MAS NMR detected the N-linked glycan, GalNAc-alpha1,4-GalNAc-alpha1,4-[Glc-beta1,3-]GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac, where Bac is 2,4-diacetamido-2,4,6-trideoxy-d-glucopyranose, in C. jejuni and Campylobacter coli [4].
  • OBJECTIVE: To evaluate the long-term tolerability and effectiveness of extended-release mixed amphetamine salts (MAS XR; Adderall XR) in children with attention-deficit/hyperactivity disorder (ADHD) [14].
  • A 31P CP/MAS NMR study on dehydration of disodium clodronate tetrahydrate [15].
  • The lymphoproliferation (LP) test was performed with one bacterial recall antigen (PPD) and four different mitogens (phytohemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and a novel mitogen derived from mycoplasma arthritidis - MAS) [16].
  • In this study HR MAS spectra of breast cancer tissue from 10 patients have been compared to conventional high-resolution spectra of perchloric acid extracts of the same tissue type [17].

Biological context of MAS1

  • To evaluate the cellular and functional changes induced in cone photoreceptors by an oncogene, the Mas1 protooncogene was targeted to the cones of transgenic mice by the human red/green opsin promoter [1].
  • The mammalian proto-oncogene MAS has been identified as a novel neuronal angiotensin receptor, which responds preferentially to Ang III, and has other unusual pharmacological properties [18].
  • The time course of AT(1) receptor-CFP up-regulation was also markedly slower than that of induction of MAS expression [13].
  • The presence of this common heptasaccharide in multiple campylobacter isolates demonstrates the conservation of the N-linked protein glycosylation pathway in this organism and describes the first report of HR-MAS NMR detection of N-linked glycans on glycoproteins from intact bacterial cells [4].
  • Kinetics and mechanism of the beta- to alpha-CuAlCl(4) phase transition: a time-resolved (63)Cu MAS NMR and powder X-ray diffraction study [19].

Anatomical context of MAS1

  • Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene [1].
  • By making use of a novel intragenic polymorphism, we have studied the expression of the MAS gene in three heterozygous human fetuses [20].
  • Cell type-specific expression of the Mas proto-oncogene in testis [21].
  • These and other studies suggest that the cellular requirement for T cell activation by MAS, PHA, and Con A may all be distinct [3].
  • Anti-HLA.DR-mediated inhibition of lymphocyte functions, however, was not specific for MAS inasmuch as viral-induced IFN was also suppressed, as was Con A-induced proliferation [3].

Associations of MAS1 with chemical compounds

  • The understanding of the MAS/angiotensin receptor may compel a basic rethinking of many aspects of the cardiovascular biology of the renin-angiotensin system [18].
  • HR-MAS NMR examination of growth from individual colonies of C. jejuni NCTC11168 indicated that the capsular glycan modifications are also phase-variable [4].
  • To study chiral recognition phenomena in the presence of the CSP, (1)H HR/MAS 2D transfer NOESY investigations in methanol-d(4) have been undertaken with various solutes including N-3,5-dinitrobenzoyl derivatives of leucine (DNB-Leu) and N-acetyl phenylalanine (Ac-Phe) [22].
  • 19F MAS NMR quantification of accessible hydroxyl sites on fiberglass surfaces [23].
  • Lanosterol 14alpha-demethylase (CYP51) produces MAS sterols, intermediates in cholesterol biosynthesis that can reinitiate meiosis in mouse oocytes [24].

Other interactions of MAS1

  • Hence both MAS and the neighboring IGF2R gene are not imprinted in humans [20].

Analytical, diagnostic and therapeutic context of MAS1

  • The materials have been characterized by SEM, TEM, XRD, (13)C NMR MAS, XPS, FTIR spectroscopy, and BET surface area measurements [25].
  • Nitrogen adsorption provided strong evidence of the presence of uniformly sized pores and the lack of phase separation up to TEVS:TEOS ratios as high as 13:7 (65% TEVS loading), whereas (29)Si MAS NMR and high-resolution thermogravimetry showed essentially quantitative incorporation of the organosilane [26].
  • The structure of these solids was elucidated by single-crystal (180 K) and powder X-ray diffraction and further characterized by chemical analysis, thermogravimetry, scanning electron microscopy, (29)Si MAS NMR, and photoluminescence spectroscopy [27].
  • The materials are characterized by a variety of spectroscopic ((13)C and (29)Si CP MAS NMR, X-ray diffraction) and quantitative (TGA/DTA, elemental analysis, acid capacity titration) techniques [28].
  • The presence of molecularly ordered ethylene groups was confirmed by powder X-ray diffraction, (29)Si and (13)C MAS NMR, and Raman spectroscopy [29].


  1. Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene. Xu, X., Quiambao, A.B., Roveri, L., Pardue, M.T., Marx, J.L., Röhlich, P., Peachey, N.S., Al-Ubaidi, M.R. Exp. Neurol. (2000) [Pubmed]
  2. Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma. Yamada, Y. Blood (1983) [Pubmed]
  3. Induction of human gamma interferons by a mitogen derived form Mycoplasma arthritidis and by Phytohemagglutinin: differential inhibition with monoclonal anti-HLA.DR antibodies. Cole, B.C., Thorpe, R.N. J. Immunol. (1983) [Pubmed]
  4. Detection of conserved N-linked glycans and phase-variable lipooligosaccharides and capsules from campylobacter cells by mass spectrometry and high resolution magic angle spinning NMR spectroscopy. Szymanski, C.M., Michael, F.S., Jarrell, H.C., Li, J., Gilbert, M., Larocque, S., Vinogradov, E., Brisson, J.R. J. Biol. Chem. (2003) [Pubmed]
  5. Ultrahigh field MAS NMR dipolar correlation spectroscopy of the histidine residues in light-harvesting complex II from photosynthetic bacteria reveals partial internal charge transfer in the B850/His complex. Alia, n.u.l.l., Matysik, J., Soede-Huijbregts, C., Baldus, M., Raap, J., Lugtenburg, J., Gast, P., van Gorkom, H.J., Hoff, A.J., de Groot, H.J. J. Am. Chem. Soc. (2001) [Pubmed]
  6. An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertension. Wilens, T.E., Zusman, R.M., Hammerness, P.G., Podolski, A., Whitley, J., Spencer, T.J., Gignac, M., Biederman, J. The Journal of clinical psychiatry. (2006) [Pubmed]
  7. The reliability of child psychiatric diagnosis. A comparison among Danish child psychiatrists of traditional diagnoses and a multiaxial diagnostic system. Skovgaard, A.M., Isager, T., Jørgensen, O.S. Acta psychiatrica Scandinavica. (1988) [Pubmed]
  8. Short-term cardiovascular effects of mixed amphetamine salts extended release in children and adolescents with oppositional defiant disorder. Connor, D.F., Spencer, T.J. CNS spectrums (2005) [Pubmed]
  9. Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy. Tsang, T.M., Woodman, B., McLoughlin, G.A., Griffin, J.L., Tabrizi, S.J., Bates, G.P., Holmes, E. J. Proteome Res. (2006) [Pubmed]
  10. The multiaxial system of ICD-10: evaluation of a preliminary draft in a multicentric field trial. Michels, R., Siebel, U., Freyberger, H.J., Stieglitz, R.D., Schaub, R.T., Dilling, H. Psychopathology. (1996) [Pubmed]
  11. Altered chromosome 6 in immortal human fibroblasts. Hubbard-Smith, K., Patsalis, P., Pardinas, J.R., Jha, K.K., Henderson, A.S., Ozer, H.L. Mol. Cell. Biol. (1992) [Pubmed]
  12. Changes of adult T cell leukemia cell surface antigens at relapse or at exacerbation phase after chemotherapy defined by use of monoclonal antibodies. Yamada, Y., Kamihira, S., Amagasaki, T., Kinoshita, K., Kusano, M., Ikeda, S., Toriya, K., Suzuyama, J., Ichimaru, M. Blood (1984) [Pubmed]
  13. Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS. Canals, M., Jenkins, L., Kellett, E., Milligan, G. J. Biol. Chem. (2006) [Pubmed]
  14. Long-term tolerability and effectiveness of once-daily mixed amphetamine salts (Adderall XR) in children with ADHD. McGough, J.J., Biederman, J., Wigal, S.B., Lopez, F.A., McCracken, J.T., Spencer, T., Zhang, Y., Tulloch, S.J. Journal of the American Academy of Child and Adolescent Psychiatry. (2005) [Pubmed]
  15. A 31P CP/MAS NMR study on dehydration of disodium clodronate tetrahydrate. Timonen, J.T., Pohjala, E., Nikander, H., Pakkanen, T.T. Pharm. Res. (1998) [Pubmed]
  16. Decreased production of interferon alpha and interferon gamma in leucocyte cultures of schizophrenic patients. Moises, H.W., Schindler, L., Leroux, M., Kirchner, H. Acta psychiatrica Scandinavica. (1985) [Pubmed]
  17. High-resolution magic angle spinning MRS of breast cancer tissue. Sitter, B., Sonnewald, U., Spraul, M., Fjösne, H.E., Gribbestad, I.S. NMR in biomedicine. (2002) [Pubmed]
  18. Molecular and cell biology of angiotensin receptors. Hanley, M.R. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
  19. Kinetics and mechanism of the beta- to alpha-CuAlCl(4) phase transition: a time-resolved (63)Cu MAS NMR and powder X-ray diffraction study. Liu, H., Sullivan, R.M., Hanson, J.C., Grey, C.P., Martin, J.D. J. Am. Chem. Soc. (2001) [Pubmed]
  20. The MAS proto-oncogene is not imprinted in humans. Riesewijk, A.M., Schepens, M.T., Mariman, E.M., Ropers, H.H., Kalscheuer, V.M. Genomics (1996) [Pubmed]
  21. Cell type-specific expression of the Mas proto-oncogene in testis. Alenina, N., Baranova, T., Smirnow, E., Bader, M., Lippoldt, A., Patkin, E., Walther, T. J. Histochem. Cytochem. (2002) [Pubmed]
  22. Characterization of a chiral stationary phase by HR/MAS NMR spectroscopy and investigation of enantioselective interaction with chiral ligates by transferred NOE. Hellriegel, C., Skogsberg, U., Albert, K., Lämmerhofer, M., Maier, N.M., Lindner, W. J. Am. Chem. Soc. (2004) [Pubmed]
  23. 19F MAS NMR quantification of accessible hydroxyl sites on fiberglass surfaces. Fry, R.A., Tsomaia, N., Pantano, C.G., Mueller, K.T. J. Am. Chem. Soc. (2003) [Pubmed]
  24. Cyclic adenosine 3',5'-monophosphate(cAMP)/cAMP-responsive element modulator (CREM)-dependent regulation of cholesterogenic lanosterol 14alpha-demethylase (CYP51) in spermatids. Rozman, D., Fink, M., Fimia, G.M., Sassone-Corsi, P., Waterman, M.R. Mol. Endocrinol. (1999) [Pubmed]
  25. Porous carbon powders prepared by ultrasonic spray pyrolysis. Skrabalak, S.E., Suslick, K.S. J. Am. Chem. Soc. (2006) [Pubmed]
  26. Metamorphosis of ordered mesopores to micropores: periodic silica with unprecedented loading of pendant reactive organic groups transforms to periodic microporous silica with tailorable pore size. Kruk, M., Asefa, T., Jaroniec, M., Ozin, G.A. J. Am. Chem. Soc. (2002) [Pubmed]
  27. Photoluminescent layered lanthanide silicates. Ananias, D., Kostova, M., Almeida Paz, F.A., Ferreira, A., Carlos, L.D., Klinowski, J., Rocha, J. J. Am. Chem. Soc. (2004) [Pubmed]
  28. Design of heterogeneous catalysts via multiple active site positioning in organic-inorganic hybrid materials. Dufaud, V., Davis, M.E. J. Am. Chem. Soc. (2003) [Pubmed]
  29. Bifunctional hybrid mesoporous organoaluminosilicates with molecularly ordered ethylene groups. Xia, Y., Wang, W., Mokaya, R. J. Am. Chem. Soc. (2005) [Pubmed]
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