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Gene Review

Ccl21a  -  chemokine (C-C motif) ligand 21A (serine)

Mus musculus

Synonyms: 6CKBAC2, 6Ckine, ALP, AW987545, CKb9, ...
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Disease relevance of Ccl21b

  • TCA-4 protein was not detected on the luminal surface of PLN HEVs in plt/plt mice, which have a congenital defect in T cell homing to PLNs [1].
  • Similar findings are seen when mice are treated with pertussis toxin, which blocks chemokine signaling in vivo. plt/plt mice had increased susceptibility to L. donovani infection compared with wild-type mice, as determined by spleen and liver parasite burden [2].

High impact information on Ccl21b

  • Focus formation in rat fibroblasts exposed to a tumour promoter after transfer of polyoma plt and myc oncogenes [3].
  • Both parameters were comparably reduced for WT T lymphocytes migrating in T cell areas of plt/plt mice lacking CCR7 ligands [4].
  • Homing experiments in paucity of lymph node T cells (plt/plt) mice, which do not express CCR7 ligands in secondary lymphoid organs, revealed that T(CM) migrate to PLNs at approximately 20% of wild-type (WT) levels, whereas homing of naive T cells was reduced by 95% [5].
  • Sticking of T(CM) in plt/plt HEVs was pertussis toxin sensitive and was blocked by anti-CXCL12 (SDF-1alpha) [5].
  • Accordingly, a large fraction of endogenous CD8(+) T cells in plt/plt PLNs displayed a T(CM) phenotype [5].

Biological context of Ccl21b


Anatomical context of Ccl21b


Associations of Ccl21b with chemical compounds

  • In this study we demonstrate that FTY720 rescues the homing defect in both CCR7(-/-) mice and plt mice [12].
  • Although airway inflammation and response to acetylcholine were significantly reduced compared with BALB/c mice, significant eosinophilic inflammation and hyperresponsiveness were also observed in plt mice after 2 weeks of inhalation [8].
  • Studies on the effect of actinomycin D or cycloheximide treatment indicated that the vitamin may enhance de novo synthesis of ALP [13].
  • Moreover, the anti-estrogen tamoxifen eliminated the stimulation of MC3T3-E1 cells on the proliferation, ALP activity and collagen synthesis by soy extract, indicating that the main action of the soy extract on osteoblastic MC3T3-E1 cells is similar to that of estrogen effects [14].
  • Identical enzyme labels (alkaline phosphatase, ALP) and substrates (p-aminophenyl phosphate, PAPP) are used for all analytes [15].

Regulatory relationships of Ccl21b

  • Anti-CXCL9/Mig was administered for 2 weeks post-transplant to determine whether impairment of activated T-cell migration could further prolong cardiac allograft survival in plt recipients [6].

Other interactions of Ccl21b

  • We also show that the NALT of Cxcl13(-/-) and plt/plt mice exhibits some, but not all, of the structural and functional defects observed in the NALT of Ltalpha(-/-) mice [11].
  • In contrast, accumulation of mRNA for IL-10 was elevated in plt/plt mice [2].

Analytical, diagnostic and therapeutic context of Ccl21b

  • Accordingly, T cells from plt heart transplant recipients demonstrated poor anti-donor responses in ex vivo MLR, compared to wt heart or wt and plt skin recipients [6].
  • The numbers of ALP-positive cells in the mouse fibroblastic cell line C3H10T1/2 and the mouse osteoblastic cell line MC3T3-E1 were increased by co-culture with chicken fibroblasts transfected with chicken Shh cDNA encoding amino-terminal peptide (Shh-N) [16].
  • Controls were untreated (NT) or received only the vaccination protocol (ALP) [17].


  1. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. Stein, J.V., Rot, A., Luo, Y., Narasimhaswamy, M., Nakano, H., Gunn, M.D., Matsuzawa, A., Quackenbush, E.J., Dorf, M.E., von Andrian, U.H. J. Exp. Med. (2000) [Pubmed]
  2. Loss of Dendritic Cell Migration and Impaired Resistance to Leishmania donovani Infection in Mice Deficient in CCL19 and CCL21. Ato, M., Maroof, A., Zubairi, S., Nakano, H., Kakiuchi, T., Kaye, P.M. J. Immunol. (2006) [Pubmed]
  3. Focus formation in rat fibroblasts exposed to a tumour promoter after transfer of polyoma plt and myc oncogenes. Connan, G., Rassoulzadegan, M., Cuzin, F. Nature (1985) [Pubmed]
  4. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. Worbs, T., Mempel, T.R., Bölter, J., von Andrian, U.H., Förster, R. J. Exp. Med. (2007) [Pubmed]
  5. CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. Scimone, M.L., Felbinger, T.W., Mazo, I.B., Stein, J.V., Von Andrian, U.H., Weninger, W. J. Exp. Med. (2004) [Pubmed]
  6. CXCL9 antagonism further extends prolonged cardiac allograft survival in CCL19/CCL21-deficient mice. Colvin, B.L., Wang, Z., Nakano, H., Wu, W., Kakiuchi, T., Fairchild, R.L., Thomson, A.W. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2005) [Pubmed]
  7. A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4. Nakano, H., Mori, S., Yonekawa, H., Nariuchi, H., Matsuzawa, A., Kakiuchi, T. Blood (1998) [Pubmed]
  8. Role of CCL21 and CCL19 in allergic inflammation in the ovalbumin-specific murine asthmatic model. Yamashita, N., Tashimo, H., Matsuo, Y., Ishida, H., Yoshiura, K., Sato, K., Yamashita, N., Kakiuchi, T., Ohta, K. J. Allergy Clin. Immunol. (2006) [Pubmed]
  9. The oncogenic potential of a prostate cancer-derived androgen receptor mutant. Shi, X.B., Xue, L., Tepper, C.G., Gandour-Edwards, R., Ghosh, P., Kung, H.J., Devere White, R.W. Prostate (2007) [Pubmed]
  10. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Luther, S.A., Tang, H.L., Hyman, P.L., Farr, A.G., Cyster, J.G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  11. Role of CXC chemokine ligand 13, CC chemokine ligand (CCL) 19, and CCL21 in the organization and function of nasal-associated lymphoid tissue. Rangel-Moreno, J., Moyron-Quiroz, J., Kusser, K., Hartson, L., Nakano, H., Randall, T.D. J. Immunol. (2005) [Pubmed]
  12. CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: modulation by FTY720. Henning, G., Ohl, L., Junt, T., Reiterer, P., Brinkmann, V., Nakano, H., Hohenberger, W., Lipp, M., Förster, R. J. Exp. Med. (2001) [Pubmed]
  13. Effects of 1,25-dihydroxyvitamin D3 on osteoblastic MC3T3-E1 cells. Kurihara, N., Ishizuka, S., Kiyoki, M., Haketa, Y., Ikeda, K., Kumegawa, M. Endocrinology (1986) [Pubmed]
  14. Soybean ethanol extract increases the function of osteoblastic MC3T3-E1 cells. Choi, E.M., Suh, K.S., Kim, Y.S., Choue, R.W., Koo, S.J. Phytochemistry (2001) [Pubmed]
  15. Feasibility studies of simultaneous multianalyte amperometric immunoassay based on spatial resolution. Ding, Y., Zhou, L., Halsall, H.B., Heineman, W.R. Journal of pharmaceutical and biomedical analysis. (1999) [Pubmed]
  16. Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation. Kinto, N., Iwamoto, M., Enomoto-Iwamoto, M., Noji, S., Ohuchi, H., Yoshioka, H., Kataoka, H., Wada, Y., Yuhao, G., Takahashi, H.E., Yoshiki, S., Yamaguchi, A. FEBS Lett. (1997) [Pubmed]
  17. Effect of hydroxyethyl starch (HES) in reducing parasite load in experimental visceral leishmaniasis. Jarecki-Black, J.C., Atkins, L., Pratt, K.M., Pepkowitz, S.H., Glassman, A.B. Ann. Clin. Lab. Sci. (1986) [Pubmed]
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