The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ccl19  -  chemokine (C-C motif) ligand 19

Mus musculus

Synonyms: C-C motif chemokine 19, CKb11, EBI1 ligand chemokine, ELC, Elc, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ccl19

  • The antitumor efficacy of EBV-induced molecule 1 ligand CC chemokine (ELC/CCL19) was evaluated in a murine lung cancer model [1].
  • They specifically chemotaxed towards both CCL19 or CCL21 in a concentration dependent and pertussis toxin-sensitive manner comparable to naive lymphocytes in vitro [2].
  • This same AnTat 1.1 ELC, which is thus silent as the parasite develops in the insect vector, can be reactivated without duplication during the first parasitemia wave following cyclical transmission [3].
  • To examine the potency of two beta-chemokines as immunomodulators, plasmid DNA encoding beta-chemokines CCL19 and CCL21 (CCR7L) was codelivered intranasally with plasmid DNA or recombinant vaccinia virus encoding herpes simplex virus (HSV) gB (HSV-gB) in a prime-and-boost vaccination strategy [4].
  • In addition following mucosal challenge of herpes simplex virus-immune mice with virus, those that had received CCL21 or CCL19 during priming contained a higher frequency of responding CD4 T cells in lymph nodes and the site of infection [5].

High impact information on Ccl19

  • We show that myosin containing the mutant ELC has abnormal function, map the mutant residues on the three-dimensional structure of myosin and suggest that the mutations disrupt the stretch activation response of the cardiac papillary muscles [6].
  • CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells [7].
  • Importantly, only activated DCs that migrated from the periphery to draining lymph nodes, but not resting steady-state DCs residing within lymph nodes, expressed high levels of CCR7 in vivo and responded to CCL19 with the production of proinflammatory cytokines [7].
  • Subsequent studies showed that CCL19 enhanced T cell proliferation by inducing maturation of DCs, resulting in upregulation of costimulatory molecules and the production of proinflammatory cytokines [7].
  • Thus, our data suggest an alternative G-alpha(i)-dependent, CCR7-CCL19/CCL21-independent mechanism for lymphocyte homing through HEVs which is strongly augmented in the presence of FTY720 [8].

Biological context of Ccl19


Anatomical context of Ccl19


Associations of Ccl19 with chemical compounds

  • Compared with diluent-treated tumor-bearing mice, intratumoral injection of recombinant ELC/CCL19 led to significant systemic reduction in tumor volumes (p < 0.01) [1].
  • Importantly, lungs from all groups expressed CXCL13, CCL21, and CCL19 and displayed organized follicular neolymphoid structures after infection with M. tuberculosis, which suggests that the lung served as a selectin ligand-independent priming site for immune responses to mycobacterial infection [15].
  • Here, we report that Tyrphostin (Tyr) AG490, a pharmacological inhibitor of Janus family tyrosine kinases (Jaks), blocked the chemotactic response of primary mouse lymphocytes to CCL19 and CCL21 in a dose-dependent manner [16].
  • The lymphocyte-expressed chemokine receptor CCR7 is playing an important role during this process, as its HEV-presented ligands CCL19 and CCL21 can trigger rapid integrin activation under flow in addition to inducing a chemotactic response, which may participate in transmigration and/or interstitial migration [16].

Regulatory relationships of Ccl19


Other interactions of Ccl19


Analytical, diagnostic and therapeutic context of Ccl19


  1. EBV-induced molecule 1 ligand chemokine (ELC/CCL19) promotes IFN-gamma-dependent antitumor responses in a lung cancer model. Hillinger, S., Yang, S.C., Zhu, L., Huang, M., Duckett, R., Atianzar, K., Batra, R.K., Strieter, R.M., Dubinett, S.M., Sharma, S. J. Immunol. (2003) [Pubmed]
  2. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Alt, C., Laschinger, M., Engelhardt, B. Eur. J. Immunol. (2002) [Pubmed]
  3. Inactivation and reactivation of a variant-specific antigen gene in cyclically transmitted Trypanosoma brucei. Delauw, M.F., Pays, E., Steinert, M., Aerts, D., Van Meirvenne, N., Le Ray, D. EMBO J. (1985) [Pubmed]
  4. Codelivery of CCR7 ligands as molecular adjuvants enhances the protective immune response against herpes simplex virus type 1. Toka, F.N., Gierynska, M., Rouse, B.T. J. Virol. (2003) [Pubmed]
  5. Influence of CCR7 ligand DNA preexposure on the magnitude and duration of immunity. Lee, Y., Eo, S.K., Rouse, R.J., Rouse, B.T. Virology (2003) [Pubmed]
  6. Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle. Poetter, K., Jiang, H., Hassanzadeh, S., Master, S.R., Chang, A., Dalakas, M.C., Rayment, I., Sellers, J.R., Fananapazir, L., Epstein, N.D. Nat. Genet. (1996) [Pubmed]
  7. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Marsland, B.J., Bättig, P., Bauer, M., Ruedl, C., Lässing, U., Beerli, R.R., Dietmeier, K., Ivanova, L., Pfister, T., Vogt, L., Nakano, H., Nembrini, C., Saudan, P., Kopf, M., Bachmann, M.F. Immunity (2005) [Pubmed]
  8. CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: modulation by FTY720. Henning, G., Ohl, L., Junt, T., Reiterer, P., Brinkmann, V., Nakano, H., Hohenberger, W., Lipp, M., Förster, R. J. Exp. Med. (2001) [Pubmed]
  9. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Luther, S.A., Tang, H.L., Hyman, P.L., Farr, A.G., Cyster, J.G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  10. CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities. Yanagawa, Y., Onoé, K. Blood (2003) [Pubmed]
  11. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. Nakano, H., Gunn, M.D. J. Immunol. (2001) [Pubmed]
  12. Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs. Van, V.Q., Lesage, S., Bouguermouh, S., Gautier, P., Rubio, M., Levesque, M., Nguyen, S., Galibert, L., Sarfati, M. EMBO J. (2006) [Pubmed]
  13. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. Okada, T., Ngo, V.N., Ekland, E.H., Förster, R., Lipp, M., Littman, D.R., Cyster, J.G. J. Exp. Med. (2002) [Pubmed]
  14. CXCL9 antagonism further extends prolonged cardiac allograft survival in CCL19/CCL21-deficient mice. Colvin, B.L., Wang, Z., Nakano, H., Wu, W., Kakiuchi, T., Fairchild, R.L., Thomson, A.W. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2005) [Pubmed]
  15. Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis. Schreiber, T., Ehlers, S., Aly, S., Hölscher, A., Hartmann, S., Lipp, M., Lowe, J.B., Hölscher, C. J. Immunol. (2006) [Pubmed]
  16. CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. Stein, J.V., Soriano, S.F., M'rini, C., Nombela-Arrieta, C., de Buitrago, G.G., Rodríguez-Frade, J.M., Mellado, M., Girard, J.P., Martínez-A, C. Blood (2003) [Pubmed]
  17. CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells. Iijima, N., Yanagawa, Y., Clingan, J.M., Onoé, K. Int. Immunol. (2005) [Pubmed]
  18. TNF family molecule LIGHT regulates chemokine CCL27 expression on mouse embryonic stem cell-derived dendritic cells through NF-kappaB activation. Zou, G.M., Hu, W.Y., Wu, W. Cell. Signal. (2007) [Pubmed]
  19. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. Luther, S.A., Bidgol, A., Hargreaves, D.C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., Cyster, J.G. J. Immunol. (2002) [Pubmed]
  20. The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. Miyoshi, K., Wakioka, T., Nishinakamura, H., Kamio, M., Yang, L., Inoue, M., Hasegawa, M., Yonemitsu, Y., Komiya, S., Yoshimura, A. Oncogene (2004) [Pubmed]
  21. CCL19 induces rapid dendritic extension of murine dendritic cells. Yanagawa, Y., Onoé, K. Blood (2002) [Pubmed]
  22. Ectopic expression of CCL19 impairs alloimmune response in mice. Krautwald, S., Ziegler, E., Förster, R., Ohl, L., Amann, K., Kunzendorf, U. Immunology (2004) [Pubmed]
WikiGenes - Universities