The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Foxj1  -  forkhead box J1

Mus musculus

Synonyms: FKHL-13, Fkhl13, Forkhead box protein J1, Forkhead-related protein FKHL13, HFH-4, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Foxj1


High impact information on Foxj1

  • One of these mammalian family members, HNF-3/fork head homolog-4 (HFH-4), was isolated by PCR amplification of rodent brain cDNA and exhibits abundant expression in the adult bronchiolar epithelium [6].
  • The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo [6].
  • We used in vitro DNA-binding site selection with recombinant HFH-4 protein and determined that the HFH-4 protein recognizes the DNA consensus sequences HWDTGTTTGTTTA or KTTTGTTGTTKTW (where H is not G, W is A or T, D is not C, and K is G or T) [6].
  • In support of these binding studies, cotransfection assays show that HFH-4 potentiates expression of the HNF-3alpha and clara cell secretory protein promoter regions [6].
  • The unique temporal and spatial pattern of HFH-4 gene expression in the developing lung defines this protein as a marker for the initiation of bronchial epithelial cell differentiation and suggests that it may play an important role in cell fate determination during lung development [7].

Biological context of Foxj1


Anatomical context of Foxj1


Regulatory relationships of Foxj1

  • In vitro, Sox17 inhibited Sftpc and enhanced Foxj1 promoter activity, consistent with its expression in proximal airway cells [13].
  • Previous studies suggest that the forkhead transcription factor Foxj1 inhibits spontaneous autoimmunity in part by antagonizing NF-kappaB activation [3].

Other interactions of Foxj1


Analytical, diagnostic and therapeutic context of Foxj1

  • Foxj1 deficiency resulted in multiorgan systemic inflammation, exaggerated Th1 cytokine production, and T cell proliferation in autologous mixed lymphocyte reactions [17].
  • The morphology of the lungs from SP-C/HFH-4 embryos (day 18 postconception) was distinctly abnormal, and the severity of the alterations correlated with the level of transgene expression as detected by in situ hybridization [12].
  • RT-PCR revealed an absence of left-right dynein (lrd) expression in the embryonic lungs of hfh-4(-)/- mice, suggesting that HFH-4 may act by regulating expression of members of the dynein family of genes [18].
  • HNF-3/forkhead homologue-4 (HFH-4), a transcription factor of the winged-helix/forkhead family, was detected by immunohistochemistry in tissue of the developing mouse [16].


  1. Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice. Tamakoshi, T., Itakura, T., Chandra, A., Uezato, T., Yang, Z., Xue, X.D., Wang, B., Hackett, B.P., Yokoyama, T., Miura, N. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. Effects of paramyxoviral infection on airway epithelial cell Foxj1 expression, ciliogenesis, and mucociliary function. Look, D.C., Walter, M.J., Williamson, M.R., Pang, L., You, Y., Sreshta, J.N., Johnson, J.E., Zander, D.S., Brody, S.L. Am. J. Pathol. (2001) [Pubmed]
  3. Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress. Srivatsan, S., Peng, S.L. J. Immunol. (2005) [Pubmed]
  4. Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family member. Brody, S.L., Hackett, B.P., White, R.A. Genomics (1997) [Pubmed]
  5. No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD). Maiti, A.K., Bartoloni, L., Mitchison, H.M., Meeks, M., Chung, E., Spiden, S., Gehrig, C., Rossier, C., DeLozier-Blanchet, C.D., Blouin, J., Gardiner, R.M., Antonarakis, S.E. Cytogenet. Cell Genet. (2000) [Pubmed]
  6. The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Lim, L., Zhou, H., Costa, R.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium. Hackett, B.P., Brody, S.L., Liang, M., Zeitz, I.D., Bruns, L.A., Gitlin, J.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  8. Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6. Lin, L., Brody, S.L., Peng, S.L. J. Immunol. (2005) [Pubmed]
  9. Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells. You, Y., Huang, T., Richer, E.J., Schmidt, J.E., Zabner, J., Borok, Z., Brody, S.L. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  10. Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice. Zhang, M., Bolfing, M.F., Knowles, H.J., Karnes, H., Hackett, B.P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. Gomperts, B.N., Gong-Cooper, X., Hackett, B.P. J. Cell. Sci. (2004) [Pubmed]
  12. HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo. Tichelaar, J.W., Lim, L., Costa, R.H., Whitsett, J.A. Dev. Biol. (1999) [Pubmed]
  13. Sox17 influences the differentiation of respiratory epithelial cells. Park, K.S., Wells, J.M., Zorn, A.M., Wert, S.E., Whitsett, J.A. Dev. Biol. (2006) [Pubmed]
  14. Foxj1 is required for apical localization of ezrin in airway epithelial cells. Huang, T., You, Y., Spoor, M.S., Richer, E.J., Kudva, V.V., Paige, R.C., Seiler, M.P., Liebler, J.M., Zabner, J., Plopper, C.G., Brody, S.L. J. Cell. Sci. (2003) [Pubmed]
  15. The bone morphogenic protein antagonist gremlin regulates proximal-distal patterning of the lung. Lu, M.M., Yang, H., Zhang, L., Shu, W., Blair, D.G., Morrisey, E.E. Dev. Dyn. (2001) [Pubmed]
  16. HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung. Tichelaar, J.W., Wert, S.E., Costa, R.H., Kimura, S., Whitsett, J.A. J. Histochem. Cytochem. (1999) [Pubmed]
  17. Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1. Lin, L., Spoor, M.S., Gerth, A.J., Brody, S.L., Peng, S.L. Science (2004) [Pubmed]
  18. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. Chen, J., Knowles, H.J., Hebert, J.L., Hackett, B.P. J. Clin. Invest. (1998) [Pubmed]
WikiGenes - Universities