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Gene Review

Rn28s1  -  28S ribosomal RNA

Mus musculus

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Disease relevance of LOC236598


High impact information on LOC236598


Biological context of LOC236598


Anatomical context of LOC236598


Other interactions of LOC236598


Analytical, diagnostic and therapeutic context of LOC236598

  • Using both heterologous rabbit antisera and mouse monoclonal antibody to RNA.DNA hybrids, we have mapped the in situ hybridization locus of the 18/28S ribosomal RNA fraction to a single large band on polytene autosome 3 in Drosophila heteroneura and Drosophila silvestris [16].
  • The integrity of RNA was evaluated with the intactness of 18S and 28S ribosomal RNA by electrophoresis and by the length of individual gene transcripts using RT-PCR [17].
  • However, P. yoelii-specific 28S ribosomal RNA gene product was detected after 15 cycles of PCR in animals inoculated via the tail vein but was not detected until 25 cycles in animals inoculated via the intrahepatic portal circulation [3].
  • Quantitation of RNA dot blots hybridized with a 28S ribosomal RNA-specific cDNA probe showed that storage phosphor imaging was more sensitive than screen-enhanced x-ray film autoradiography in identifying low amounts of total RNA (1-10 micrograms) [18].


  1. Probing the structure of mouse Ehrlich ascites cell 5.8S, 18S and 28S ribosomal RNA in situ. Holmberg, L., Melander, Y., Nygård, O. Nucleic Acids Res. (1994) [Pubmed]
  2. Cloning and determination of the transcription termination site of ribosomal RNA gene of the mouse. Kominami, R., Mishima, Y., Urano, Y., Sakai, M., Muramatsu, M. Nucleic Acids Res. (1982) [Pubmed]
  3. Detection of Plasmodium yoelii stage mRNA in BALB/c mice. Lau, A.O., Sacci, J.B., Azad, A.F. J. Parasitol. (2001) [Pubmed]
  4. Suppression of production of mouse 28S ribosomal RNA in mouse-human hybrids segregating mouse chromosomes. Croce, C.M., Talavera, A., Basilico, C., Miller, O.J. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  5. Effects of dimethylnitrosamine on RNA synthesis and metabolism in mouse liver. Garyfallides, S., Kyrtopoulos, S.A., Sekeris, C.E. Cancer Res. (1984) [Pubmed]
  6. Selective inhibition of 28S ribosomal RNA in macrophages activated by interferon-gamma or -beta. Varesio, L., Clayton, M., Radzioch, D., Bonvini, E. J. Immunol. (1987) [Pubmed]
  7. Nucleotide sequence neighbouring a late modified guanylic residue within the 28S ribosomal RNA of several eukaryotic cells. Eladari, M.E., Hampe, A., Galibert, F. Nucleic Acids Res. (1977) [Pubmed]
  8. Evolutionary implication of heterogeneity of the nontranscribed spacer region of ribosomal DNA repeating units in various subspecies of Mus musculus. Suzuki, H., Miyashita, N., Moriwaki, K., Kominami, R., Muramatsu, M., Kanehisa, T., Bonhomme, F., Petras, M.L., Yu, Z.C., Lu, D.Y. Mol. Biol. Evol. (1986) [Pubmed]
  9. Location of genes coding for 18S and 28S ribosomal RNA within the genome of Mus musculus. Elsevier, S.M., Ruddle, F.H. Chromosoma (1975) [Pubmed]
  10. Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouse. Swisshelm, K., Disteche, C.M., Thorvaldsen, J., Nelson, A., Salk, D. Mutat. Res. (1990) [Pubmed]
  11. Biologically active interleukin 2-ricin A chain fusion proteins may require intracellular proteolytic cleavage to exhibit a cytotoxic effect. Cook, J.P., Savage, P.M., Lord, J.M., Roberts, L.M. Bioconjug. Chem. (1993) [Pubmed]
  12. Comparison of glyceraldehyde-3-phosphate dehydrogenase and 28S-ribosomal RNA gene expression as RNA loading controls for northern blot analysis of cell lines of varying malignant potential. Bhatia, P., Taylor, W.R., Greenberg, A.H., Wright, J.A. Anal. Biochem. (1994) [Pubmed]
  13. A novel ribotoxin with ribonuclease activity that specifically cleaves a single phosphodiester bond in rat 28S ribosomal RNA and inactivates ribosome. Xu, H., He, W.J., Liu, W.Y. Arch. Biochem. Biophys. (2004) [Pubmed]
  14. Age-dependent IGF-1 regulation of gene transcription of Ca2+ channels in skeletal muscle. Zheng, Z., Messi, M.L., Delbono, O. Mech. Ageing Dev. (2001) [Pubmed]
  15. Expression of cysteine proteases in extraembryonic tissues during mouse embryogenesis. Sol-Church, K., Shipley, J., Beckman, D.A., Mason, R.W. Arch. Biochem. Biophys. (1999) [Pubmed]
  16. Location of the 18/28S ribosomal RNA genes in two Hawaiian Drosophila species by monoclonal immunological identification of RNA.DNA hybrids in situ. Stuart, W.D., Bishop, J.G., Carson, H.L., Frank, M.B. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  17. Differential gene expression analysis using paraffin-embedded tissues after laser microdissection. Kim, J.O., Kim, H.N., Hwang, M.H., Shin, H.I., Kim, S.Y., Park, R.W., Park, E.Y., Kim, I.S., van Wijnen, A.J., Stein, J.L., Lian, J.B., Stein, G.S., Choi, J.Y. J. Cell. Biochem. (2003) [Pubmed]
  18. Storage phosphor imaging technique improves the accuracy of RNA quantitation using 32P-labeled cDNA probes. Zouboulis, C.C., Tavakkol, A. BioTechniques (1994) [Pubmed]
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