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Gene Review

Car14  -  carbonic anhydrase 14

Mus musculus

Synonyms: AW536446, CA XIV, CA-XIV, Ca14, Carbonate dehydratase XIV, ...
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Disease relevance of Car14

  • We suggest that CA XIV is the target of CA inhibitors that enhance subretinal fluid absorption in macular edema [1].

High impact information on Car14


Biological context of Car14


Anatomical context of Car14


Other interactions of Car14

  • In the SL membrane, only CA IV and CA XIV are present [6].
  • Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney [4].
  • The CA domain of CA XIV is highly homologous with those of known CAs, especially extracellular CAs including CA XII, IX, VI, and IV [4].
  • Future studies will be necessary to assign functions to CA-II and CA-XIV in the mouse neural retina [7].
  • We determined herein that CA-XIV, a approximately 45kDa membrane protein, is expressed in retina, as it is in kidney [7].

Analytical, diagnostic and therapeutic context of Car14


  1. Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes. Nagelhus, E.A., Mathiisen, T.M., Bateman, A.C., Haug, F.M., Ottersen, O.P., Grubb, J.H., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain. Shah, G.N., Ulmasov, B., Waheed, A., Becker, T., Makani, S., Svichar, N., Chesler, M., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes. Whittington, D.A., Grubb, J.H., Waheed, A., Shah, G.N., Sly, W.S., Christianson, D.W. J. Biol. Chem. (2004) [Pubmed]
  4. Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney. Mori, K., Ogawa, Y., Ebihara, K., Tamura, N., Tashiro, K., Kuwahara, T., Mukoyama, M., Sugawara, A., Ozaki, S., Tanaka, I., Nakao, K. J. Biol. Chem. (1999) [Pubmed]
  5. The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV. Parkkila, S., Kivelä, A.J., Kaunisto, K., Parkkila, A.K., Hakkola, J., Rajaniemi, H., Waheed, A., Sly, W.S. BMC gastroenterology [electronic resource]. (2002) [Pubmed]
  6. Expression of Membrane-bound Carbonic Anhydrases IV, IX, and XIV in the Mouse Heart. Scheibe, R.J., Gros, G., Parkkila, S., Waheed, A., Grubb, J.H., Shah, G.N., Sly, W.S., Wetzel, P. J. Histochem. Cytochem. (2006) [Pubmed]
  7. Carbonic anhydrase XIV identified as the membrane CA in mouse retina: strong expression in Müller cells and the RPE. Ochrietor, J.D., Clamp, M.F., Moroz, T.P., Grubb, J.H., Shah, G.N., Waheed, A., Sly, W.S., Linser, P.J. Exp. Eye Res. (2005) [Pubmed]
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