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Chemical Compound Review

evans blue     tetrasodium(6Z)-4-amino-6- [[4-[4-[(2Z)-2...

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Disease relevance of evans blue

  • Pulmonary responses detected (i.e., eicosanoid production, leukocytic infiltration, Evan's blue extravasation, beta-glucuronidase release) were attenuated to varying degrees by treatment of rats in which pancreatitis was initiated with the PAF receptor antagonists (WEB2170 and BN52021) [1].
  • We also found that NGF produced plasma extravasation in rat skin, using the Evan's blue method, with a dose dependency similar to that determined for hyperalgesia [2].
  • To systematically evaluate this model, we first demonstrated correlation of ischemia times (10-60 min) with infarct sizes [3.5 +/- 1.3 to 42 +/- 5.2% area at risk (AAR), Evan's blue/triphenyltetrazolium chloride staining] [3].
  • Combined with mild hypothermia, THAM treatment significantly reduced the Evan's blue extravasation (35 +/- 7 ng/g wet tissue; p < 0.05) compared to normothermia (63 +/- 7 ng/g wet tissue) [4].
  • Previous studies from our laboratory have demonstrated penetration of Evan's blue dye into the brain in profound fetal asphyxia, suggesting that vasogenic brain edema (BE) might be an immediate contributing factor in asphyxial brain injury [5].

High impact information on evans blue

  • Echocardiographic and Doppler flow evaluations together with the Evan's blue dilution technique showed that the total plasma volume of EC GC-A KO mice was increased by 11-13%, even under conditions of normal dietary salt intake [6].
  • To test whether bile acids could also cause histamine release from cutaneous mast cells in vivo, rats were injected intradermally with bile acid solutions and histamine release assessed by capillary leakage of Evan's blue dye [7].
  • At the dose that increased ethanol-induced damage, none of the leukotrienes tested significantly altered gastric vascular permeability, as measured by Evan's blue leakage [8].
  • This technique makes use of the fluorescence properties and albumin affinity of Evans blue dye (T-1824) [9].
  • METHODS: Inflammation was quantified by estimating myeloperoxidase (MPO) activity in the intestinal lumen, extravascular accumulation of Evan's blue (EB) in the intestine, and number of red blood cells (RBCs) in veins in histological sections [10].

Chemical compound and disease context of evans blue


Biological context of evans blue


Anatomical context of evans blue


Associations of evans blue with other chemical compounds


Gene context of evans blue


Analytical, diagnostic and therapeutic context of evans blue


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