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Chemical Compound Review

Mediator     2-[1-[3-(trifluoromethyl) phenyl]propan-2...

Synonyms: Benflurex, Minolip, benfluorex, Benfluorexum, Benfluramate, ...
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Disease relevance of Benfluramate

  • Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats [1].
  • Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo [2].
  • In conclusion, benfluorex potentiates the effects of hypocaloric diet on weight loss and on glycemic control in obese NIDDM patients treated with insulin, and this effect seems to be the result of an improved insulin sensitivity [2].
  • Adjunct treatments comprise a few pharmacological approaches which may help to improve glycaemic control by correcting some abnormalities frequently associated with NIDDM, such as obesity (serotoninergic anorectic agents) and hyperlipidaemia (benfluorex) [3].
  • Treatment once a day for 14 days with 25 mg benfluorex per kg body weight lowered body weight, decreased circulating insulin and resulted in an increase in hepatic glycogen [4].

High impact information on Benfluramate


Chemical compound and disease context of Benfluramate


Biological context of Benfluramate


Anatomical context of Benfluramate


Associations of Benfluramate with other chemical compounds


Gene context of Benfluramate


Analytical, diagnostic and therapeutic context of Benfluramate


  1. Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats. Serradas, P., Blondel, O., Bailbe, D., Portha, B. Diabetes (1993) [Pubmed]
  2. Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. Pontiroli, A.E., Pacchioni, M., Piatti, P.M., Cassisa, C., Camisasca, R., Pozza, G. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  3. Drug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments. Scheen, A.J. Drugs (1997) [Pubmed]
  4. Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats. Tielens, A.G., van den Heuvel, J.M., Schmitz, M.G., Geelen, M.J. Biochem. Pharmacol. (1993) [Pubmed]
  5. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Kohl, C., Ravel, D., Girard, J., Pégorier, J.P. Diabetes (2002) [Pubmed]
  6. Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benfluorex. Storlien, L.H., Oakes, N.D., Pan, D.A., Kusunoki, M., Jenkins, A.B. Diabetes (1993) [Pubmed]
  7. Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. Bianchi, R., Bongers, V., Bravenboer, B., Erkelens, D.W. Diabetes Care (1993) [Pubmed]
  8. Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study. Moulin, P., Andre, M., Alawi, H., dos Santos, L.C., Khalid, A.K., Koev, D., Moore, R., Serban, V., Picandet, B., Francillard, M. Diabetes Care (2006) [Pubmed]
  9. Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men. Nestler, J.E., Beer, N.A., Jakubowicz, D.J., Colombo, C., Beer, R.M. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  10. Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats. Muñoz, P., Chillarón, J., Camps, M., Castelló, A., Furriols, M., Testar, X., Palacín, M., Zorzano, A. Biochem. Pharmacol. (1996) [Pubmed]
  11. Effects of benfluorex and fenofibrate treatment on mitochondrial and peroxisomal marker enzymes in rat liver. Van Veldhoven, P., Declercq, P.E., Debeer, L.J., Mannaerts, G.P. Biochem. Pharmacol. (1984) [Pubmed]
  12. Valvular heart disease in a patient taking benfluorex. Noize, P., Sauer, M., Bruneval, P., Moreau, M., Pathak, A., Bagheri, H., Montastruc, J.L. Fundamental & clinical pharmacology (2006) [Pubmed]
  13. Effect of benfluorex on insulin secretion and insulin action in streptozotocin-diabetic rats. Portha, B., Serradas, P., Bailbé, D., Blondel, O., Picarel, F. Diabetes/metabolism reviews. (1993) [Pubmed]
  14. Acute effect of benfluorex on glucose metabolism. Bailey, C.J., Page, T., Day, C., Thornburn, C.C. Biochem. Pharmacol. (1992) [Pubmed]
  15. Mechanisms responsible for the inhibitory effects of benfluorex on hepatic intermediary metabolism. Geelen, M.J. Biochem. Pharmacol. (1983) [Pubmed]
  16. Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex. Brindley, D.N., Hales, P., al-Sieni, A.I., Russell, J.C. Biochim. Biophys. Acta (1991) [Pubmed]
  17. Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats. Russell, J.C., Graham, S.E., Dolphin, P.J., Amy, R.M., Wood, G.O., Brindley, D.N. Atherosclerosis (1997) [Pubmed]
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