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Gene Review

Gja4  -  gap junction protein, alpha 4

Rattus norvegicus

Synonyms: Connexin-37, Cx37, Cxn-37, Gap junction alpha-4 protein
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Disease relevance of Gja4


High impact information on Gja4


Biological context of Gja4


Anatomical context of Gja4

  • These findings suggest that renin-angiotensin system blockade corrects the decreased expression of Cx37 and Cx40 in arterial endothelial cells of hypertensive rats, partly independently of blood pressure, whereas the expression of Cx43 changed in the opposite direction [7].
  • CONCLUSIONS: The demonstration of Cx37 as the dominant Cx in the media of the CA highlights the potential heterogeneity in Cx involvement in vascular smooth muscle [9].
  • OBJECTIVE: To determine the connexins (Cxs) involved in intercellular coupling within vascular muscle, the present study has quantified mRNA and protein expression for Cx37, Cx40, Cx43, and Cx45 in the caudal artery (CA) and thoracic aorta (ThA) of the rat [9].
  • Sciatic nerve connexin 37 mRNA increases were proportional to the extent of thermal hyperalgesia, but skin, muscle, and lumbar spinal cord connexin 37 mRNA showed no significant changes [2].
  • The aim of the present study was to compare the expression of Cx37, 40 and 43 in the smooth muscle and endothelium of a large elastic artery and two smaller muscular arteries of the rat [10].

Other interactions of Gja4


Analytical, diagnostic and therapeutic context of Gja4


  1. Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium. Rignault, S., Haefliger, J.A., Gasser, D., Markert, M., Nicod, P., Liaudet, L., Waeber, B., Feihl, F. Crit. Care Med. (2005) [Pubmed]
  2. Induction of connexin 37 expression in a rat model of neuropathic pain. Lin, S.H., Lu, C.Y., Muhammad, R., Chou, W.Y., Lin, F.C., Wu, P.C., Lin, C.R., Yang, L.C. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  3. Connexin 37 mutations in rat hepatic angiosarcomas induced by vinyl chloride. Saito, T., Barbin, A., Omori, Y., Yamasaki, H. Cancer Res. (1997) [Pubmed]
  4. Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells. Sato, T., Haimovici, R., Kao, R., Li, A.F., Roy, S. Diabetes (2002) [Pubmed]
  5. Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins. Bruzzone, R., Haefliger, J.A., Gimlich, R.L., Paul, D.L. Mol. Biol. Cell (1993) [Pubmed]
  6. Regulated assembly of connexin33 and connexin43 into rat Sertoli cell gap junctions. Tan, I.P., Roy, C., Sáez, J.C., Sáez, C.G., Paul, D.L., Risley, M.S. Biol. Reprod. (1996) [Pubmed]
  7. Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats. Kansui, Y., Fujii, K., Nakamura, K., Goto, K., Oniki, H., Abe, I., Shibata, Y., Iida, M. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  8. Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. Yeh, H.I., Chang, H.M., Lu, W.W., Lee, Y.N., Ko, Y.S., Severs, N.J., Tsai, C.H. J. Histochem. Cytochem. (2000) [Pubmed]
  9. Connexin37 is the major connexin expressed in the media of caudal artery. Rummery, N.M., Hickey, H., McGurk, G., Hill, C.E. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  10. Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function. Hill, C.E., Rummery, N., Hickey, H., Sandow, S.L. Clin. Exp. Pharmacol. Physiol. (2002) [Pubmed]
  11. Connexin expression patterns in the rat cornea: molecular evidence for communication compartments. Laux-Fenton, W.T., Donaldson, P.J., Kistler, J., Green, C.R. Cornea (2003) [Pubmed]
  12. Expression of connexins in the normal and obstructed developing kidney. Silverstein, D.M., Thornhill, B.A., Leung, J.C., Vehaskari, V.M., Craver, R.D., Trachtman, H.A., Chevalier, R.L. Pediatr. Nephrol. (2003) [Pubmed]
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