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Gene Review

pol  - 

Bovine leukemia virus

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Disease relevance of pol


High impact information on pol


Chemical compound and disease context of pol

  • The NH2- and COOH-terminal regions of the pol product show stronger homologies with those of avian, rather than murine, type C retrovirus, and its structure is identical to that of avian virus [9].

Biological context of pol


Anatomical context of pol


Associations of pol with chemical compounds


Analytical, diagnostic and therapeutic context of pol

  • To examine the effects of these cytokines on BLV expression, BLV tax and pol mRNA and p24 protein were quantified by competitive PCR and immunoblotting, respectively [16].
  • Southern-blot hybridization and partial sequencing of the pol and env genes were used to characterize BLV-integrated provirus of seropositive cattle from two dairy herds in northern Italy [20].


  1. Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS. Starcich, B.R., Hahn, B.H., Shaw, G.M., McNeely, P.D., Modrow, S., Wolf, H., Parks, E.S., Parks, W.P., Josephs, S.F., Gallo, R.C. Cell (1986) [Pubmed]
  2. Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Sanchez-Pescador, R., Power, M.D., Barr, P.J., Steimer, K.S., Stempien, M.M., Brown-Shimer, S.L., Gee, W.W., Renard, A., Randolph, A., Levy, J.A. Science (1985) [Pubmed]
  3. Identification of HTLV-III/LAV sor gene product and detection of antibodies in human sera. Kan, N.C., Franchini, G., Wong-Staal, F., DuBois, G.C., Robey, W.G., Lautenberger, J.A., Papas, T.S. Science (1986) [Pubmed]
  4. Genomic structure of HTLV (human T-cell leukemia virus): detection of defective genome and its amplification in MT-2 cells. Kobayashi, N., Konishi, H., Sabe, H., Shigesada, K., Noma, T., Honjo, T., Hatanaka, M. EMBO J. (1984) [Pubmed]
  5. Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus. Pyeon, D., Diaz, F.J., Splitter, G.A. J. Virol. (2000) [Pubmed]
  6. HTLV-III gag protein is processed in yeast cells by the virus pol-protease. Kramer, R.A., Schaber, M.D., Skalka, A.M., Ganguly, K., Wong-Staal, F., Reddy, E.P. Science (1986) [Pubmed]
  7. Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions. Sodroski, J., Goh, W.C., Rosen, C., Tartar, A., Portetelle, D., Burny, A., Haseltine, W. Science (1986) [Pubmed]
  8. HTLV x-gene product: requirement for the env methionine initiation codon. Wachsman, W., Golde, D.W., Temple, P.A., Orr, E.C., Clark, S.C., Chen, I.S. Science (1985) [Pubmed]
  9. Complete nucleotide sequence of the genome of bovine leukemia virus: its evolutionary relationship to other retroviruses. Sagata, N., Yasunaga, T., Tsuzuku-Kawamura, J., Ohishi, K., Ogawa, Y., Ikawa, Y. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  10. Expression in Escherichia coli of open reading frame gene segments of HTLV-III. Chang, N.T., Chanda, P.K., Barone, A.D., McKinney, S., Rhodes, D.P., Tam, S.H., Shearman, C.W., Huang, J., Chang, T.W., Gallo, R.C. Science (1985) [Pubmed]
  11. The bovine leukemia virus encapsidation signal is discontinuous and extends into the 5' end of the gag gene. Mansky, L.M., Krueger, A.E., Temin, H.M. J. Virol. (1995) [Pubmed]
  12. Bovine leukemia virus structural gene vectors are immunogenic and lack pathogenicity in a rabbit model. Kucerova, L., Altanerova, V., Altaner, C., Boris-Lawrie, K. J. Virol. (1999) [Pubmed]
  13. Failure to detect human T-cell leukemia virus-related sequences in multiple sclerosis blood. Chen, I.S., Haislip, A.M., Myers, L.W., Ellison, G.W., Merrill, J.E. Arch. Neurol. (1990) [Pubmed]
  14. Molecular studies of human T-cell leukemia virus and adult T-cell leukemia. Franchini, G., Wong-Staal, F., Gallo, R.C. J. Invest. Dermatol. (1984) [Pubmed]
  15. Complete nucleotide sequence of the AIDS virus, HTLV-III. Ratner, L., Haseltine, W., Patarca, R., Livak, K.J., Starcich, B., Josephs, S.F., Doran, E.R., Rafalski, J.A., Whitehorn, E.A., Baumeister, K. Nature (1985) [Pubmed]
  16. Regulation of bovine leukemia virus tax and pol mRNA levels by interleukin-2 and -10. Pyeon, D., Splitter, G.A. J. Virol. (1999) [Pubmed]
  17. Retrovirus-like activity in an immunosuppressed dog: pathological and immunological findings. Modiano, J.F., Getzy, D.M., Akol, K.G., Van Winkle, T.J., Cockerell, G.L. J. Comp. Pathol. (1995) [Pubmed]
  18. Viral status and antibody response in cattle inoculated with recombinant bovine leukemia virus-vaccinia virus vaccines after challenge exposure with bovine leukemia virus-infected lymphocytes. Cherney, T.M., Schultz, R.D. Am. J. Vet. Res. (1996) [Pubmed]
  19. Bovine leukosis virus: recloning of specific DNA fragments. Zajac, V., Bán, J., Altaner, C., Kettmann, R., Burny, A. Neoplasma (1986) [Pubmed]
  20. Molecular characterization of a variant of proviral bovine leukaemia virus (BLV). Molteni, E., Agresti, A., Meneveri, R., Marozzi, A., Malcovati, M., Bonizzi, L., Poli, G., Ginelli, E. Zentralblatt Veterinarmedizin Reihe B (1996) [Pubmed]
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