Gene Review:
GRK6 - G protein-coupled receptor kinase 6
Homo sapiens
Synonyms:
G protein-coupled receptor kinase GRK6, GPRK6
- Regulation of human melanocortin 1 receptor signaling and trafficking by thr-308 and ser-316 and its alteration in variant alleles associated with red hair and skin cancer. Sánchez-Laorden, B.L., Jiménez-Cervantes, C., García-Borrón, J.C. J. Biol. Chem. (2007)
- Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells. Willets, J.M., Challiss, R.A., Nahorski, S.R. J. Biol. Chem. (2002)
- G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. Tiruppathi, C., Yan, W., Sandoval, R., Naqvi, T., Pronin, A.N., Benovic, J.L., Malik, A.B. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Identification of additional members of human G-protein-coupled receptor kinase multigene family. Haribabu, B., Snyderman, R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Differentially regulated expression of the G-protein-coupled receptor kinases, betaARK and GRK6, during myelomonocytic cell development in vitro. Loudon, R.P., Perussia, B., Benovic, J.L. Blood (1996)
- Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. Loudon, R.P., Benovic, J.L. J. Biol. Chem. (1994)
- Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. Benovic, J.L., Gomez, J. J. Biol. Chem. (1993)
- Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor. Lazari, M.F., Liu, X., Nakamura, K., Benovic, J.L., Ascoli, M. Mol. Endocrinol. (1999)
- Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. Stoffel, R.H., Inglese, J., Macrae, A.D., Lefkowitz, R.J., Premont, R.T. Biochemistry (1998)
- Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium. Brenninkmeijer, C.B., Price, S.A., López Bernal, A., Phaneuf, S. J. Endocrinol. (1999)
- G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes. Jewell-Motz, E.A., Liggett, S.B. J. Biol. Chem. (1996)
- Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor. Diviani, D., Lattion, A.L., Larbi, N., Kunapuli, P., Pronin, A., Benovic, J.L., Cotecchia, S. J. Biol. Chem. (1996)
- Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2. Iwata, K., Luo, J., Penn, R.B., Benovic, J.L. J. Biol. Chem. (2005)
- Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. Zhou, H., Yan, F., Tai, H.H. J. Pharmacol. Exp. Ther. (2001)
- Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells. Hagen, S.A., Kondyra, A.L., Grocott, H.P., El-Moalem, H., Bainbridge, D., Mathew, J.P., Newman, M.F., Reves, J.G., Schwinn, D.A., Kwatra, M.M. Anesthesiology (2003)
- G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. Hall, R.A., Spurney, R.F., Premont, R.T., Rahman, N., Blitzer, J.T., Pitcher, J.A., Lefkowitz, R.J. J. Biol. Chem. (1999)
- The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. Lodowski, D.T., Tesmer, V.M., Benovic, J.L., Tesmer, J.J. J. Biol. Chem. (2006)
- Inhibition of G protein-coupled receptor kinase subtypes by Ca2+/calmodulin. Chuang, T.T., Paolucci, L., De Blasi, A. J. Biol. Chem. (1996)
- Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation. Pronin, A.N., Carman, C.V., Benovic, J.L. J. Biol. Chem. (1998)
- Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. Lombardi, M.S., Kavelaars, A., Schedlowski, M., Bijlsma, J.W., Okihara, K.L., Van de Pol, M., Ochsmann, S., Pawlak, C., Schmidt, R.E., Heijnen, C.J. FASEB J. (1999)
- Identification and chromosomal localization of a processed pseudogene of human GRK6. Gagnon, A.W., Benovic, J.L. Gene (1997)