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Gene Review

Cav3  -  caveolin 3

Rattus norvegicus

Synonyms: Caveolin-3
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Disease relevance of Cav3


High impact information on Cav3

  • Caveolin-1 and -2 show the widest range of expression, whereas caveolin-3 expression is restricted to muscle cell types [4].
  • Finally, a minor fraction of a protein that has been designated as a receptor for activated protein kinase C resides in caveolae and (along with caveolin-3) could represent a mechanism to target PKC isoforms to cardiomyocyte caveolae [5].
  • Biochemical as well as immunocytochemical studies suggested that the PMCA in large part was colocalized with caveolin 3 in caveolae of cardiomyocytes [6].
  • The experiments showed that cellular caveolin-3, a fraction of cellular ANP-RB, and a fraction of cellular ANP colocalize at the plasmalemma of cultured atrial myocytes and of freshly dissociated atrial myocytes [7].
  • Using sucrose density fractionation of adult cardiac myocytes, we detected Cav-3 in both buoyant membrane fractions (BF) and heavy/non-buoyant fractions (HF); beta2-adrenergic receptors (AR) in BF; and AC5/6, beta1-AR, M4-muscarinic acetylcholine receptors (mAChR), mu-opioid receptors, and Galpha(s) in both BF and HF [8].

Chemical compound and disease context of Cav3


Biological context of Cav3


Anatomical context of Cav3


Associations of Cav3 with chemical compounds


Physical interactions of Cav3

  • Although caveolin-2 might be expected to interact in an fashion analogous to that of caveolin-3, it generally has not been detected in cardiomyocytes [9].

Co-localisations of Cav3


Other interactions of Cav3


Analytical, diagnostic and therapeutic context of Cav3


  1. Accumulation of molecules involved in alpha1-adrenergic signal within caveolae: caveolin expression and the development of cardiac hypertrophy. Fujita, T., Toya, Y., Iwatsubo, K., Onda, T., Kimura, K., Umemura, S., Ishikawa, Y. Cardiovasc. Res. (2001) [Pubmed]
  2. Behavior of caveolae and caveolin-3 during the development of myocyte hypertrophy. Kikuchi, T., Oka, N., Koga, A., Miyazaki, H., Ohmura, H., Imaizumi, T. J. Cardiovasc. Pharmacol. (2005) [Pubmed]
  3. Up-regulation of cardiac nitric oxide synthase 1-derived nitric oxide after myocardial infarction in senescent rats. Damy, T., Ratajczak, P., Robidel, E., Bendall, J.K., Oliviéro, P., Boczkowski, J., Ebrahimian, T., Marotte, F., Samuel, J.L., Heymes, C. FASEB J. (2003) [Pubmed]
  4. Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury. Galbiati, F., Volonte, D., Gil, O., Zanazzi, G., Salzer, J.L., Sargiacomo, M., Scherer, P.E., Engelman, J.A., Schlegel, A., Parenti, M., Okamoto, T., Lisanti, M.P. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Activated protein kinase C isoforms target to cardiomyocyte caveolae : stimulation of local protein phosphorylation. Rybin, V.O., Xu, X., Steinberg, S.F. Circ. Res. (1999) [Pubmed]
  6. Overexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats. Hammes, A., Oberdorf-Maass, S., Rother, T., Nething, K., Gollnick, F., Linz, K.W., Meyer, R., Hu, K., Han, H., Gaudron, P., Ertl, G., Hoffmann, S., Ganten, U., Vetter, R., Schuh, K., Benkwitz, C., Zimmer, H.G., Neyses, L. Circ. Res. (1998) [Pubmed]
  7. Type B atrial natriuretic peptide receptor in cardiac myocyte caveolae. Doyle, D.D., Ambler, S.K., Upshaw-Earley, J., Bastawrous, A., Goings, G.E., Page, E. Circ. Res. (1997) [Pubmed]
  8. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head, B.P., Patel, H.H., Roth, D.M., Lai, N.C., Niesman, I.R., Farquhar, M.G., Insel, P.A. J. Biol. Chem. (2005) [Pubmed]
  9. Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3. Rybin, V.O., Grabham, P.W., Elouardighi, H., Steinberg, S.F. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  10. Expression and localization of caveolins during postnatal development in rat heart: implication of thyroid hormone. Ratajczak, P., Oliviéro, P., Marotte, F., Kolar, F., Ostadal, B., Samuel, J.L. J. Appl. Physiol. (2005) [Pubmed]
  11. Modulation of the caveolin-3 and Akt status in caveolae by insulin resistance in H9c2 cardiomyoblasts. Ha, H., Pak, Y. Exp. Mol. Med. (2005) [Pubmed]
  12. Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. Shin, T., Kim, H., Jin, J.K., Moon, C., Ahn, M., Tanuma, N., Matsumoto, Y. J. Neuroimmunol. (2005) [Pubmed]
  13. Regional myocardial ischemia-induced activation of MAPKs is associated with subcellular redistribution of caveolin and cholesterol. Ballard-Croft, C., Locklar, A.C., Kristo, G., Lasley, R.D. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  14. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. Feron, O., Smith, T.W., Michel, T., Kelly, R.A. J. Biol. Chem. (1997) [Pubmed]
  15. Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts. Wang, X., Abdel-Rahman, A.A. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  16. Localization of caveolin-3 in the sinus endothelial cells of the rat spleen. Uehara, K., Miyoshi, M. Cell Tissue Res. (2002) [Pubmed]
  17. Sub-cellular distribution of endothelin signaling pathway components in ventricular myocytes and heart: lack of preformed caveolar signalosomes. Boivin, B., Villeneuve, L.R., Farhat, N., Chevalier, D., Allen, B.G. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  18. The effect of pregnancy and delivery on the function and ultrastructure of the rat bladder and urethra. Bakircioglu, M.E., Sievert, K.D., Lau, A., Lin, C.S., Lue, T.F. BJU international. (2000) [Pubmed]
  19. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. Rybin, V.O., Xu, X., Lisanti, M.P., Steinberg, S.F. J. Biol. Chem. (2000) [Pubmed]
  20. Expression of caveolin-3 in rat aortic vascular smooth muscle cells is determined by developmental state. Doyle, D.D., Upshaw-Earley, J., Bell, E., Palfrey, H.C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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