The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HIVEP3  -  human immunodeficiency virus type I...

Homo sapiens

Synonyms: FLJ16752, Human immunodeficiency virus type I enhancer-binding protein 3, KBP-1, KBP1, KIAA1555, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HIVEP3


High impact information on HIVEP3

  • The second, named KBP-1 (kappa-enhancer binding protein 1), encodes a factor that is similar to, but distinct from, NF-kappa B in its DNA-binding properties and methylation interference pattern, suggesting that at least two proteins can bind to the immunoglobulin kappa gene enhancer [6].
  • KRC encodes a large zinc finger protein that binds to the kappaB motif and to the signal sequences of V(D)J recombination [7].
  • In addition, RASSF1C was shown to induce cell cycle arrest in KRC/Y cells [2].
  • The large zinc finger protein KRC regulates transcription of target genes via the kappaB gene enhancer element [8].
  • Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells [8].

Biological context of HIVEP3


Anatomical context of HIVEP3

  • Human renal cell cancer (RCC) cell lines, ACHN and KRC/Y, with or without exposure to cytokines, were examined for their susceptibility to lymphokine-activated killer (LAK) cells [9].
  • As predicted from cDNAs, 5' untranslated region composed of the 2317 nucleotides is extremely long and contains upstream open reading frames, suggesting that translation initiation of ZAS3 transcripts by conventional cap-dependent ribosome scanning mechanism may be inefficient [10].
  • Furthermore, in HeLa cells, downregulation of KRC conferred anchorage-independent growth and promoted cell cycle progression without an intervening cytokinesis, culminating in the formation of multinucleated giant cells [8].
  • In this report, the function of KRC was studied in a RAG2-deficient blastocyst complementation animal model [3].
  • However, by 6 months of age, there was a marked deficit in CD4(+)CD8(+) thymocytes in the chimeras, suggesting that KRC may be involved in T-lymphocyte survival [3].

Associations of HIVEP3 with chemical compounds

  • The levels of cationic peroxidase activity and of KRCP transcripts in Korean radish seedlings (Raphanus sativus L. F1 Handsome Fall) were also upregulated by a low ratio of cytokinin to auxin, but not by high concentrations of cytokinin [11].

Regulatory relationships of HIVEP3


Analytical, diagnostic and therapeutic context of HIVEP3

  • Tumorigenicity was identified by tumor formation after subcutaneous injections of KRC/Y cells in nude mice, which showed close resemblance to the original tumor by light and electron microscope observations [5].


  1. Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. Hicar, M.D., Liu, Y., Allen, C.E., Wu, L.C. Genomics (2001) [Pubmed]
  2. Inactivation of RASSF1C during in vivo tumor growth identifies it as a tumor suppressor gene. Li, J., Wang, F., Protopopov, A., Malyukova, A., Kashuba, V., Minna, J.D., Lerman, M.I., Klein, G., Zabarovsky, E. Oncogene (2004) [Pubmed]
  3. Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC. Allen, C.E., Muthusamy, N., Weisbrode, S.E., Hong, J.W., Wu, L.C. Genes Chromosomes Cancer (2002) [Pubmed]
  4. Possible significance of VLA-4 (alpha 4 beta 1) for hematogenous metastasis of renal-cell cancer. Tomita, Y., Saito, T., Saito, K., Oite, T., Shimizu, F., Sato, S. Int. J. Cancer (1995) [Pubmed]
  5. Establishment and characterization of a new human renal cell carcinoma cell line (KRC/Y). Yano, H., Maruiwa, M., Sugihara, S., Kojiro, M., Noda, S., Eto, K. In Vitro Cell. Dev. Biol. (1988) [Pubmed]
  6. Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties. Rustgi, A.K., Van 't Veer, L.J., Bernards, R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. The kappaB and V(D)J recombination signal sequence binding protein KRC regulates transcription of the mouse metastasis-associated gene S100A4/mts1. Hjelmsoe, I., Allen, C.E., Cohn, M.A., Tulchinsky, E.M., Wu, L.C. J. Biol. Chem. (2000) [Pubmed]
  8. Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells. Allen, C.E., Wu, L.C. Exp. Cell Res. (2000) [Pubmed]
  9. Interferon gamma but not tumor necrosis factor alpha decreases susceptibility of human renal cell cancer cell lines to lymphokine-activated killer cells. Tomita, Y., Watanabe, H., Kobayashi, H., Nishiyama, T., Tsuji, S., Fujiwara, M., Sato, S. Cancer Immunol. Immunother. (1992) [Pubmed]
  10. Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes. Hong, J.W., Wu, L.C. Biochim. Biophys. Acta (2005) [Pubmed]
  11. Regulation of the activity of Korean radish cationic peroxidase promoter during dedifferentiation and differentiation. Kim, S.S., Choi, S.Y., Park, J.H., Lee, D.J. Plant Physiol. Biochem. (2004) [Pubmed]
WikiGenes - Universities