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Gene Review

Arsa  -  arylsulfatase A

Rattus norvegicus

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Disease relevance of Arsa


High impact information on Arsa


Chemical compound and disease context of Arsa


Biological context of Arsa


Anatomical context of Arsa

  • Total specific activities of cathepsin D and of arylsulfatase A in the sedimentable and nonsedimentable subcellular fractions were at least 38% lower in LIG than in MIG and HIG [9].
  • Effect of insulin-like growth factor II on uptake of arylsulfatase A by cultured rat hepatocytes and Kupffer cells [10].
  • Background: Arylsulfatase A (ASA) is an enzyme that catalyzes the degradation of sulfatides, a glycosphingolipid found in many tissues, but predominantly in myelin and kidney [7].
  • These results favored the adsorption of AS-A from epididymal fluid onto the sperm surface, rather than shunting from the acrosome as a consequence of capacitation-associated membrane priming [6].
  • Rat sperm AS-A: subcellular localization in testis and epididymis and surface distribution in epididymal sperm [6].

Associations of Arsa with chemical compounds


Other interactions of Arsa

  • A purified myelin preparation containing [35S]-labeled cerebroside sulfate (CS) was biosynthesized in developing rat brain and tested as a model of a physiological substrate for CS hydrolysis by arylsulfatase A. Particular attention was directed to the involvement of the CS sulfatase activator protein in facilitating the catabolic process [8].
  • Arylsulfatase A and B activities have been analysed in different areas of the CNS (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) during methyl mercuric chloride (MMC), N-acetyl-DL-homocysteine thiolactone (NAHT) and glutathione (GSH) treatment [13].

Analytical, diagnostic and therapeutic context of Arsa


  1. Release of arylsulfatase A but not B from rat mast cells by noncytolytic secretory stimuli. Lynch, S.M., Austen, K.F., Wasserman, S.I. J. Immunol. (1978) [Pubmed]
  2. Isolation and comparison of arylsulfatase A from rat liver and Morris hepatoma 7777. Hess, G. Eur. J. Biochem. (1983) [Pubmed]
  3. The glucagon-insulin antagonism in the regulation of cytosolic protein binding to the 3' end of phosphoenolpyruvate carboxykinase mRNA in cultured rat hepatocytes. Possible involvement in the stabilization of the mRNA. Christ, B., Nath, A. Eur. J. Biochem. (1993) [Pubmed]
  4. Increased hepatic mitochondrial capacity in rats with hydroxy-cobalamin[c-lactam]-induced methylmalonic aciduria. Krahenbuhl, S., Ray, D.B., Stabler, S.P., Allen, R.H., Brass, E.P. J. Clin. Invest. (1990) [Pubmed]
  5. Identification and characterization of arylsulfatase A and B of the rat basophil leukemia tumor. Wasserman, S.I., Austen, K.F. J. Biol. Chem. (1977) [Pubmed]
  6. Rat sperm AS-A: subcellular localization in testis and epididymis and surface distribution in epididymal sperm. Ngernsoungnern, A., Weerachatyanukul, W., Saewu, A., Thitilertdecha, S., Sobhon, P., Sretarugsa, P. Cell Tissue Res. (2004) [Pubmed]
  7. Ethanol decreases rat hepatic arylsulfatase a activity levels. Jean, S., Kasinathan, C., Buyske, S., Manowitz, P. Alcohol. Clin. Exp. Res. (2006) [Pubmed]
  8. Activator-dependent hydrolysis of myelin cerebroside sulfate by arylsulfatase A. Louis, A.I., Fluharty, A.L. Dev. Neurosci. (1991) [Pubmed]
  9. Effects of iodine intake on thyroid secondary lysosomes after subtotal thyroidectomy. Neve, P., Starling, J.R., Golstein, J., Krupp, P.P. Endocrinology (1988) [Pubmed]
  10. Effect of insulin-like growth factor II on uptake of arylsulfatase A by cultured rat hepatocytes and Kupffer cells. Schmitz, F., Bresciani, R., Hartmann, H., Braulke, T. J. Hepatol. (1995) [Pubmed]
  11. Ultrastructural cytochemistry: effect of Sorbinil on arylsulfatases in cataractous lenses. Harries, W., Tsui, J., Unakar, N.J. Curr. Eye Res. (1985) [Pubmed]
  12. Early effects of aminonucleoside on enzymes in the Golgi apparatus of rat liver. Katona, E., Moscarello, M.A. Can. J. Physiol. Pharmacol. (1975) [Pubmed]
  13. Inability of thiol compounds to restore CNS arylsulfatases inhibited by methyl mercury. Vinay, S.D., Sood, P.P. Pharmacol. Toxicol. (1991) [Pubmed]
  14. Purification of rat liver arylsulfatase A and its microheterogeneity assayed by crossed affinity-immunoelectrophoresis. Wójczyk, B., Hoja, D., Lityńska, A. Acta Biochim. Pol. (1992) [Pubmed]
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