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Gene Review

IL12RB2  -  interleukin 12 receptor, beta 2

Homo sapiens

Synonyms: IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, IL-12RB2, Interleukin-12 receptor subunit beta-2
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Disease relevance of IL12RB2


High impact information on IL12RB2


Biological context of IL12RB2


Anatomical context of IL12RB2

  • Furthermore, the effects of cytokines on IL-12R beta2 chain expression on CD4(+) T cells were investigated [12].
  • In contrast, in pleural fluid and lymph nodes at the site of disease in tuberculosis patients, in which IFN-gamma production is enhanced, IL-12R beta 2 mRNA expression was also increased [13].
  • Moreover, the production of IFN-gamma by NK cells was greatly enhanced when a small amount of interleukin-12 (IL-12) was added, and this synergistic effect was associated with increased expression of the IL-12 receptor beta2 [14].
  • We have recently shown that the differential expression of the IL-12R beta 2 chain in Th1 and Th2 cells, as measured at the mRNA level, accounts for an important regulatory mechanism in the differentiation of the two cell subsets [15].
  • Although IL-12R beta 2 was absent in freshly isolated PBMC and in cord blood cells, we were able to detect IL-12R beta 2 expression selectively in differentiated Th1 and T cytotoxic 1, but not Th2 or T cytotoxic 2 cells [15].

Associations of IL12RB2 with chemical compounds

  • Allergen RIT increases IL-12 production and IL-12R beta2 chain expression and thus may convert cytokine production from Th2 to Th1 or Th0 type in allergic asthma [12].
  • The IL-12 receptor beta2 subunit contains three tyrosine residues in its cytoplasmic domain [16].
  • The level of IL-12R beta2 chain mRNA was also upregulated to 130% after 24 h incubation with 0.1 microg/mL ribavirin (P = 0.037), whereas the beta1 chain did not change significantly under these conditions [17].

Physical interactions of IL12RB2

  • The present study demonstrates that Jak2 binds to the cytoplasmic membrane-proximal region of IL-12R beta 2, and box 2 motif and tyrosine residues in the cytoplasmic domain were not required for binding [18].

Regulatory relationships of IL12RB2


Other interactions of IL12RB2


Analytical, diagnostic and therapeutic context of IL12RB2


  1. Interleukin 12-augmented T cell proliferation of peripheral blood mononuclear cells from HIV-seropositive individuals is associated with interleukin 12 receptor beta 2 upregulation. Jones, M.L., Young, J.M., Huang, Q.R., Puls, R.L., Webber, C.A., Benson, E.M. AIDS Res. Hum. Retroviruses (2003) [Pubmed]
  2. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D.H., Gubler, U., Sinigaglia, F. J. Exp. Med. (1997) [Pubmed]
  3. Depressed IL-12-mediated signal transduction in T cells from patients with Sézary syndrome is associated with the absence of IL-12 receptor beta 2 mRNA and highly reduced levels of STAT4. Showe, L.C., Fox, F.E., Williams, D., Au, K., Niu, Z., Rook, A.H. J. Immunol. (1999) [Pubmed]
  4. Polymorphism of the 5' flanking region of the IL-12 receptor beta2 gene partially determines the clinical types of leprosy through impaired transcriptional activity. Ohyama, H., Ogata, K., Takeuchi, K., Namisato, M., Fukutomi, Y., Nishimura, F., Naruishi, H., Ohira, T., Hashimoto, K., Liu, T., Suzuki, M., Uemura, Y., Matsushita, S. J. Clin. Pathol. (2005) [Pubmed]
  5. Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease. Parrello, T., Monteleone, G., Cucchiara, S., Monteleone, I., Sebkova, L., Doldo, P., Luzza, F., Pallone, F. J. Immunol. (2000) [Pubmed]
  6. The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals. Marshall, J.D., Chehimi, J., Gri, G., Kostman, J.R., Montaner, L.J., Trinchieri, G. Blood (1999) [Pubmed]
  7. Contrasting responses to interferon beta-1b treatment in relapsing-remitting multiple sclerosis: does baseline interleukin-12p35 messenger RNA predict the efficacy of treatment? van Boxel-Dezaire, A.H., van Trigt-Hoff, S.C., Killestein, J., Schrijver, H.M., van Houwelingen, J.C., Polman, C.H., Nagelkerken, L. Ann. Neurol. (2000) [Pubmed]
  8. Role of neuronal interferon-gamma in the development of myelopathy in rats infected with human T-cell leukemia virus type 1. Miyatake, Y., Ikeda, H., Ishizu, A., Baba, T., Ichihashi, T., Suzuki, A., Tomaru, U., Kasahara, M., Yoshiki, T. Am. J. Pathol. (2006) [Pubmed]
  9. NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome. Valanciuté, A., le Gouvello, S., Solhonne, B., Pawlak, A., Grimbert, P., Lyonnet, L., Hue, S., Lang, P., Remy, P., Salomon, R., Bensman, A., Guellaën, G., Sahali, D. J. Immunol. (2004) [Pubmed]
  10. Assignment of IL12RB2 to human chromosome 1p31.3-->p31.2 between D1S230 and D1S198. Morton, S.M., Bocaccio, I., Depetris, D., Mattei, M., Dessein, A. Cytogenet. Cell Genet. (1997) [Pubmed]
  11. RNA editing of interleukin-12 receptor beta2, 2451 C-to-U (Ala 604 Val) conversion, associated with atopy. Kondo, N., Matsui, E., Kaneko, H., Aoki, M., Kato, Z., Fukao, T., Kasahara, K., Morimoto, N. Clin. Exp. Allergy (2004) [Pubmed]
  12. Allergen rush immunotherapy increases interleukin (IL)-12 production and IL-12 receptor beta2 chain expression in patients with allergic asthma. Tazaki, T., Minoguchi, K., Yokoe, T., Oda, N., Hashimoto, T., Tanaka, A., Okada, S., Yamamoto, Y., Watanabe, Y., Adachi, M. Cell. Immunol. (2004) [Pubmed]
  13. Expression of the IL-12 receptor beta 1 and beta 2 subunits in human tuberculosis. Zhang, M., Gong, J., Presky, D.H., Xue, W., Barnes, P.F. J. Immunol. (1999) [Pubmed]
  14. Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon production. Yun, C.H., Lundgren, A., Azem, J., Sjöling, A., Holmgren, J., Svennerholm, A.M., Lundin, B.S. Infect. Immun. (2005) [Pubmed]
  15. Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo. Rogge, L., Papi, A., Presky, D.H., Biffi, M., Minetti, L.J., Miotto, D., Agostini, C., Semenzato, G., Fabbri, L.M., Sinigaglia, F. J. Immunol. (1999) [Pubmed]
  16. Direct interaction of STAT4 with the IL-12 receptor. Yao, B.B., Niu, P., Surowy, C.S., Faltynek, C.R. Arch. Biochem. Biophys. (1999) [Pubmed]
  17. Ribavirin upregulates interleukin-12 receptor and induces T cell differentiation towards type 1 in chronic hepatitis C. Shiina, M., Kobayashi, K., Satoh, H., Niitsuma, H., Ueno, Y., Shimosegawa, T. J. Gastroenterol. Hepatol. (2004) [Pubmed]
  18. Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus. Yamamoto, K., Shibata, F., Miura, O., Kamiyama, R., Hirosawa, S., Miyasaka, N. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  19. T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease. Matsuoka, K., Inoue, N., Sato, T., Okamoto, S., Hisamatsu, T., Kishi, Y., Sakuraba, A., Hitotsumatsu, O., Ogata, H., Koganei, K., Fukushima, T., Kanai, T., Watanabe, M., Ishii, H., Hibi, T. Gut (2004) [Pubmed]
  20. Up-regulation of interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. Fujimoto, T., Nakamura, T., Nishiura, Y., Ichinose, K., Furuya, T., Shirabe, S., Eguchi, K. J. Neurol. Sci. (2002) [Pubmed]
  21. Simultaneous expression of Th1 cytokines and IL-4 confers severe characteristics to type I autoimmune hepatitis in children. Cherñavsky, A.C., Paladino, N., Rubio, A.E., De Biasio, M.B., Periolo, N., Cuarterolo, M., Goñi, J., Galoppo, C., Cañero-Velasco, M.C., Muñoz, A.E., Fainboim, H., Fainboim, L. Hum. Immunol. (2004) [Pubmed]
  22. T cells from human allergen-induced late asthmatic responses express IL-12 receptor beta 2 subunit mRNA and respond to IL-12 in vitro. Varga, E.M., Wachholz, P., Nouri-Aria, K.T., Verhoef, A., Corrigan, C.J., Till, S.J., Durham, S.R. J. Immunol. (2000) [Pubmed]
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