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ILF2  -  interleukin enhancer binding factor 2

Homo sapiens

Synonyms: Interleukin enhancer-binding factor 2, NF45, Nuclear factor of activated T-cells 45 kDa, PRO3063
 
 
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Disease relevance of ILF2

 

High impact information on ILF2

 

Biological context of ILF2

 

Anatomical context of ILF2

 

Associations of ILF2 with chemical compounds

  • The human and murine NF45 proteins differ only by substitution of valine by isoleucine at amino acid 142 [1].
  • Histidine-tagged NF45 and NF90 proteins, affinity-purified on nickel chelate columns, encode a NF-AT DNA-binding activity that is enhanced following T-cell stimulation, and this enhancement is blocked when T-cells are stimulated in the presence of cyclosporin A or FK506 [4].
  • The predicted protein products of ORFs N2417 and N2403 present similarities with domains from proteins of other organisms: the Candida maltosa cycloheximide-resistance protein, the human interleukin enhancer-binding factor (ILF-2) [11].
  • Three commercial NF membranes, NF45, NF70, and NTR-729HF, were characterized with 50 mM NaCl, MgSO(4), and glucose solutions [12].
 

Other interactions of ILF2

 

Analytical, diagnostic and therapeutic context of ILF2

  • Cell fractionation studies showed that NF90 and its heteromeric partner, NF45, are predominantly nuclear and largely chromatin-associated [14].
  • RT-PCR was optimized to estimate the expression level of NF45 in grass carp [8].
  • The surface and the solid/liquid interface of two polyamide membranes, one experimental (B0) and one commercial (NF45), have been characterized by X-ray photoelectronic spectroscopy (XPS), atomic force microscopy (AFM), and zeta potential, respectively [10].

References

  1. NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function. Zhao, G., Shi, L., Qiu, D., Hu, H., Kao, P.N. Exp. Cell Res. (2005) [Pubmed]
  2. The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site. Merrill, M.K., Gromeier, M. J. Virol. (2006) [Pubmed]
  3. The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. Reichman, T.W., Muñiz, L.C., Mathews, M.B. Mol. Cell. Biol. (2002) [Pubmed]
  4. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. Kao, P.N., Chen, L., Brock, G., Ng, J., Kenny, J., Smith, A.J., Corthésy, B. J. Biol. Chem. (1994) [Pubmed]
  5. Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. Marcoulatos, P., Koussidis, G., Mamuris, Z., Velissariou, V., Vamvakopoulos, N.C. J. Interferon Cytokine Res. (1996) [Pubmed]
  6. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. Ting, N.S., Kao, P.N., Chan, D.W., Lintott, L.G., Lees-Miller, S.P. J. Biol. Chem. (1998) [Pubmed]
  7. Molecular Cloning, Characterization and Expression Analysis of an ILF2 Homologue from Tetraodon nigroviridis. Wang, H.J., Shao, J.Z., Xiang, L.X., Shen, J. J. Biochem. Mol. Biol. (2006) [Pubmed]
  8. Molecular cloning, characterization and expression analysis of grass carp (Ctenopharyngodon idellus) NF45 (ILF2) cDNA, a subunit of the nuclear factor of activated T-cells (NF-AT). Lin, H.F., Shao, J.Z., Xiang, L.X., Wang, H.J. Fish Shellfish Immunol. (2006) [Pubmed]
  9. CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku. Aoki, Y., Zhao, G., Qiu, D., Shi, L., Kao, P.N. Am. J. Physiol. (1998) [Pubmed]
  10. Effect of hydration of polyamide membranes on the surface electrokinetic parameters: surface characterization by x-ray photoelectronic spectroscopy and atomic force microscopy. Ariza, M.J., Benavente, J., Rodríguez-Castellón, E., Palacio, L. Journal of colloid and interface science (2002) [Pubmed]
  11. The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae. Bergez, P., Doignon, F., Crouzet, M. Yeast (1995) [Pubmed]
  12. Recovery of ammonium lactate and removal of hardness from fermentation broth by nanofiltration. Kang, S.H., Chang, Y.K., Chang, H.N. Biotechnol. Prog. (2004) [Pubmed]
  13. Mapping interleukin enhancer binding factor 3 gene (ILF3) to human chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. Marcoulatos, P., Avgerinos, E., Tsantzalos, D.V., Vamvakopoulos, N.C. J. Interferon Cytokine Res. (1998) [Pubmed]
  14. Selective regulation of gene expression by nuclear factor 110, a member of the NF90 family of double-stranded RNA-binding proteins. Reichman, T.W., Parrott, A.M., Fierro-Monti, I., Caron, D.J., Kao, P.N., Lee, C.G., Li, H., Mathews, M.B. J. Mol. Biol. (2003) [Pubmed]
 
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