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VCAM1  -  vascular cell adhesion molecule 1

Sus scrofa

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Disease relevance of VCAM1


High impact information on VCAM1


Biological context of VCAM1


Anatomical context of VCAM1

  • Importance of CD49d-VCAM interactions in human monocyte adhesion to porcine endothelium [13].
  • Although little is known about its mechanism, recent in vitro observations suggest that the very late activation antigen-4 (VLA-4, CD49d/CD29) and vascular cell adhesion molecule-1 (VCAM-1) adhesion pathway may be involved in specific eosinophil migration [14].
  • Collectively, these data indicate that the differential compartmentalization of sIgA(+) lymphocytes between Pa and Ph tonsils may partly result from the differential expression of VCAM-1 and CCL28 [15].
  • More importantly, the vascular cell adhesion molecule-1 (VCAM-1) addressin was present in Ph tonsil and LN but neither in Pa tonsil nor in PP vascular cells, whereas both T and sIgA(+) B lymphocytes displayed similar levels of alpha4beta1(high) integrin, the ligand of VCAM-1 [15].

Associations of VCAM1 with chemical compounds


Other interactions of VCAM1

  • However, if zinc was added back, all PPAR agonists significantly downregulated the TNF-alpha-mediated induction of inflammatory transcription factors NF-kappaB and AP-1 and significantly reduced the expression of their target genes, VCAM-1 and IL-6 [7].

Analytical, diagnostic and therapeutic context of VCAM1


  1. Expression of vascular cell adhesion molecule-1 by vascular endothelial cells in immune and nonimmune inflammatory reactions in the skin. Harrison, A.A., Stocker, C.J., Chapman, P.T., Tsang, Y.T., Huehns, T.Y., Gundel, R.H., Peters, A.M., Davies, K.A., George, A.J., Robinson, M.K., Haskard, D.O. J. Immunol. (1997) [Pubmed]
  2. Prolonged reversal of chronic experimental allergic encephalomyelitis using a small molecule inhibitor of alpha4 integrin. Piraino, P.S., Yednock, T.A., Freedman, S.B., Messersmith, E.K., Pleiss, M.A., Vandevert, C., Thorsett, E.D., Karlik, S.J. J. Neuroimmunol. (2002) [Pubmed]
  3. Protective roles of polyethylene glycol and trimetazidine against cold ischemia and reperfusion injuries of pig kidney graft. Faure, J.P., Petit, I., Zhang, K., Dutheil, D., Doucet, C., Favreau, F., Eugène, M., Goujon, J.M., Tillement, J.P., Mauco, G., Vandewalle, A., Hauet, T. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2004) [Pubmed]
  4. Intravascular ultrasound molecular imaging of atheroma components in vivo. Hamilton, A.J., Huang, S.L., Warnick, D., Rabbat, M., Kane, B., Nagaraj, A., Klegerman, M., McPherson, D.D. J. Am. Coll. Cardiol. (2004) [Pubmed]
  5. Selective suppression of endothelial cell activation by arachidonic acid. Stuhlmeier, K.M., Tarn, C., Csizmadia, V., Bach, F.H. Eur. J. Immunol. (1996) [Pubmed]
  6. Porcine vascular cell adhesion molecule (VCAM) mediates endothelial cell adhesion to human T cells. Development of blocking antibodies specific for porcine VCAM. Mueller, J.P., Evans, M.J., Cofiell, R., Rother, R.P., Matis, L.A., Elliott, E.A. Transplantation (1995) [Pubmed]
  7. Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells. Reiterer, G., Toborek, M., Hennig, B. J. Nutr. (2004) [Pubmed]
  8. Rapid communication: SacI restriction fragment length polymorphism in a porcine vascular cellular adhesion molecule (VCAM1) gene. Helm, J.M., Schmitz, C.B., Tuggle, C.K., Rothschild, M.F. J. Anim. Sci. (1994) [Pubmed]
  9. Rapid communication: mapping the pig VCAM1 locus to chromosome 4 using a double-stranded conformation polymorphism marker (VCAM1-2). Tuggle, C.K., Yu, T.P., Sun, H.S., Wang, L., Rothschild, M.F. J. Anim. Sci. (1997) [Pubmed]
  10. Cloning and expression kinetics of porcine vascular cell adhesion molecule. Tsang, Y.T., Haskard, D.O., Robinson, M.K. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  11. Transcriptional profiling and growth kinetics of endothelium reveals differences between cells derived from porcine aorta versus aortic valve. Farivar, R.S., Cohn, L.H., Soltesz, E.G., Mihaljevic, T., Rawn, J.D., Byrne, J.G. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2003) [Pubmed]
  12. Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries. Zhang, L., Zalewski, A., Liu, Y., Mazurek, T., Cowan, S., Martin, J.L., Hofmann, S.M., Vlassara, H., Shi, Y. Circulation (2003) [Pubmed]
  13. Importance of CD49d-VCAM interactions in human monocyte adhesion to porcine endothelium. Kwiatkowski, P., Artrip, J.H., Ankersmit, J., Schuster, M., John, R., Wang, S.F., Ma, N., Michler, R.E., Itescu, S. Xenotransplantation (1998) [Pubmed]
  14. A monoclonal antibody against very late activation antigen-4 inhibits eosinophil accumulation and late asthmatic response in a guinea pig model of asthma. Sagara, H., Matsuda, H., Wada, N., Yagita, H., Fukuda, T., Okumura, K., Makino, S., Ra, C. Int. Arch. Allergy Immunol. (1997) [Pubmed]
  15. T and IgA B lymphocytes of the pharyngeal and palatine tonsils: differential expression of adhesion molecules and chemokines. Bourges, D., Wang, C.H., Chevaleyre, C., Salmon, H. Scand. J. Immunol. (2004) [Pubmed]
  16. An external, oversized, porous polyester stent reduces vein graft neointima formation, cholesterol concentration, and vascular cell adhesion molecule 1 expression in cholesterol-fed pigs. Angelini, G.D., Lloyd, C., Bush, R., Johnson, J., Newby, A.C. J. Thorac. Cardiovasc. Surg. (2002) [Pubmed]
  17. Human CD154 induces activation of porcine endothelial cells and up-regulation of MHC class II expression. Rushworth, S.A., Bravery, C.A., Thompson, S. Transplantation (2001) [Pubmed]
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