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Gene Review

SELE  -  selectin E

Sus scrofa

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Disease relevance of SELE


High impact information on SELE

  • Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells [5].
  • Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, calcium-dependent binding of a subfraction to L-selectin and to P-selectin, and calcium-independent binding of a larger fraction to P-selectin, the latter being disrupted by high EDTA concentrations [6].
  • Preincubation of each of the endothelial cell lines with the calcium chelator 1,-2-bis(o-aminophenoxy)ethane-N,N,N', N'-tetraacetic acetomethyl ester (BAPTA/AM) prevented the expression of VCAM-1 and E-selectin [5].
  • We pretreated neutrophils with monoclonal antibodies (mAbs) directed against these E-selectin ligands [2].
  • These findings suggest that expression of porcine E-selectin is important for the cytotoxicity of PAEC mediated by activated human NK cells and may be involved in the redox-mediated modulation of that cytotoxicity [7].

Chemical compound and disease context of SELE


Biological context of SELE


Anatomical context of SELE


Associations of SELE with chemical compounds


Regulatory relationships of SELE

  • Endothelial adhesion molecules were also variously affected, with E-selectin (CD62E) being transiently up-regulated by IL-1 alpha but CD62E showed early and sustained expression after TNF-alpha and PHA administration [17].

Other interactions of SELE


Analytical, diagnostic and therapeutic context of SELE


  1. Expression of E-selectin and its transcripts during intestinal ischemia-reperfusion injury in pigs. Braun, F., Hosseini, M., Wieland, E., Sattler, B., Laabs, S., Lorf, T., Müller, A.R., Fändrich, F., Kremer, B., Ringe, B. Transplant. Proc. (2004) [Pubmed]
  2. E-selectin ligands mediate tumor necrosis factor-induced neutrophil sequestration and pulmonary edema in guinea pig lungs. Lo, S.K., Bevilacqua, B., Malik, A.B. Circ. Res. (1994) [Pubmed]
  3. The role of E-selectin in lymphocyte and polymorphonuclear cell recruitment into cutaneous delayed hypersensitivity reactions in sensitized pigs. Binns, R.M., Whyte, A., Licence, S.T., Harrison, A.A., Tsang, Y.T., Haskard, D.O., Robinson, M.K. J. Immunol. (1996) [Pubmed]
  4. Noninvasive imaging of E-selectin expression by activated endothelium in urate crystal-induced arthritis. Chapman, P.T., Jamar, F., Harrison, A.A., Binns, R.M., Peters, A.M., Haskard, D.O. Arthritis Rheum. (1994) [Pubmed]
  5. Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells. Allen, S., Khan, S., Al-Mohanna, F., Batten, P., Yacoub, M. J. Clin. Invest. (1998) [Pubmed]
  6. Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents. Koenig, A., Norgard-Sumnicht, K., Linhardt, R., Varki, A. J. Clin. Invest. (1998) [Pubmed]
  7. Effect of redox modulation on xenogeneic target cells: the combination of nitric oxide and thiol deprivation protects porcine endothelial cells from lysis by IL-2-activated human NK cells. Tsuyuki, S., Horvath-Arcidiacono, J.A., Bloom, E.T. J. Immunol. (2001) [Pubmed]
  8. The kinetics of E-selectin expression and leukocyte traffic in BCG/PPD delayed hypersensitivity in the pig. Harrison, A.A., Whyte, A., Licence, S.T., Woolley, S.T., Binns, R.M., Haskard, D.O. Biochem. Soc. Trans. (1995) [Pubmed]
  9. Assignment of S100A11 and SELE to porcine chromosome 4 by in situ hybridization. Musilová, P., Kubícková, S., Rubes, J. Cytogenet. Cell Genet. (2001) [Pubmed]
  10. The intron-exon structure of the porcine E-selectin-encoding gene. Winkler, H., Brostjan, C., Csizmadia, V., Natarajan, G., Anrather, J., Bach, F.H. Gene (1996) [Pubmed]
  11. Molecular and functional analysis of porcine E-selectin reveals a potential role in xenograft rejection. Rollins, S.A., Evans, M.J., Johnson, K.K., Elliot, E.A., Squinto, S.P., Matis, L.A., Rother, R.P. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling. Saraswathi, V., Wu, G., Toborek, M., Hennig, B. J. Lipid Res. (2004) [Pubmed]
  13. Glucocorticoids inhibit E-selectin expression by targeting NF-kappaB and not ATF/c-Jun. Brostjan, C., Anrather, J., Csizmadia, V., Natarajan, G., Winkler, H. J. Immunol. (1997) [Pubmed]
  14. Endothelial activation in monosodium urate monohydrate crystal-induced inflammation: in vitro and in vivo studies on the roles of tumor necrosis factor alpha and interleukin-1. Chapman, P.T., Yarwood, H., Harrison, A.A., Stocker, C.J., Jamar, F., Gundel, R.H., Peters, A.M., Haskard, D.O. Arthritis Rheum. (1997) [Pubmed]
  15. Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated. Sølvik, U.Ø., Haraldsen, G., Fiane, A.E., Boretti, E., Lambris, J.D., Fung, M., Thorsby, E., Mollnes, T.E. Transplantation (2001) [Pubmed]
  16. E-selectin binds to squamous cell carcinoma and keratinocyte cell lines. Allen, M.H., Robinson, M.K., Stephens, P.E., MacDonald, D.M., Barker, J.N. J. Invest. Dermatol. (1996) [Pubmed]
  17. Lymphocyte subsets and adhesion molecules in cutaneous inflammation induced by inflammatory agonists: correlation between E-selectin and gamma delta TcR+ lymphocytes. Whyte, A., Licence, S.T., Robinson, M.K., van der Lienden, K. Lab. Invest. (1996) [Pubmed]
  18. TNF-alpha, IL-4, and IFN-gamma regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells. Stocker, C.J., Sugars, K.L., Harari, O.A., Landis, R.C., Morley, B.J., Haskard, D.O. J. Immunol. (2000) [Pubmed]
  19. In vitro study of malaria parasite induced disruption of blood-brain barrier. Treeratanapiboon, L., Psathaki, K., Wegener, J., Looareesuwan, S., Galla, H.J., Udomsangpetch, R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  20. Endothelial cell activation by pore-forming structures: pivotal role for interleukin-1alpha. Saadi, S., Holzknecht, R.A., Patte, C.P., Platt, J.L. Circulation (2000) [Pubmed]
  21. Expression of vascular cell adhesion molecule-1 by vascular endothelial cells in immune and nonimmune inflammatory reactions in the skin. Harrison, A.A., Stocker, C.J., Chapman, P.T., Tsang, Y.T., Huehns, T.Y., Gundel, R.H., Peters, A.M., Davies, K.A., George, A.J., Robinson, M.K., Haskard, D.O. J. Immunol. (1997) [Pubmed]
  22. A newly established porcine aortic endothelial cell line: characterization and application to the study of human-to-swine graft rejection. Malassagne, B., Taboit, F., Conti, F., Batteux, F., Atia, N., Chéreau, C., Conjeaud, H., Théron, M.C., Attal, J., Braet, F., Houdebine, L.M., Calmus, Y., Houssin, D., Weill, B. Exp. Cell Res. (1998) [Pubmed]
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