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Gene Review

VCL  -  vinculin

Sus scrofa

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Disease relevance of VCL

  • In vivo, VCL, ATA, and lamifiban administered 2 minutes after intimal injuries stopped thrombus growth, prevented the cyclic thrombotic process, and induced gradual thrombus dissolution [1].
  • Verapamil and semotiadil exhibited a significantly greater effect than diltiazem on the mean ventricular cycle length (VCLmeun), on the maximal ventricular cycle length (VCLmax) and on the standard deviation of the VCL (SD(VCL)) during atrial flutter [2].

High impact information on VCL


Chemical compound and disease context of VCL


Biological context of VCL


Anatomical context of VCL


Associations of VCL with chemical compounds

  • The dissimilar calpain inhibitors 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid (PD150606) or chloroacetic acid N'-[6,7-dichloro-4-phenyl)-3-oxo-3,4-dihydroquinoxalin-2-yl] hydrazide (SJA7029) preserved cytoskeleton-associated paxillin, talin, and vinculin levels and prevented PI influx and LDH release in antimycin A-exposed or hypoxic RPTs [9].
  • One important underlying mechanism appears to be regulation of vinculin incorporation into adhesive junctions by cyclic AMP [13].
  • In the presence of limiting amounts of liposomes, the alpha-actinin/vinculin ratio was markedly decreased in the liposome fractions [14].
  • It is shown in this study that the higher-molecular-mass variant metavinculin and alpha-actinin, also share this property. alpha-Actinin and vinculin were also shown to associate with phosphatidylserine liposomes by chromatography of protein/lipid mixtures on a Bio-Gel A-5m column [14].
  • Immunoblotting confirmed significantly greater vinculin in triton-insoluble fractions from monolayer cells compared with follicular cells [13].

Other interactions of VCL

  • The relocation of beta-catenin and vinculin away from intercalated discs in failing myocytes may impair the mechanical linkage between N-cadherin and thin filaments and adversely affect myocyte shape [15].
  • Since contractile proteins often vary with the cell type and may require different conditions for their interactions, we have developed a procedure which allows the parallel purification of actin-binding protein (ABP), vinculin, alpha-actinin, gelsolin as well as actin and tropomyosin from the same batch of cells [16].
  • In conduit intrapulmonary elastic arteries alpha, beta and gamma actin, the 204, 200 and 196 kDa myosin heavy chain (MHC) isoforms and vinculin were localised by immunohistochemistry [17].

Analytical, diagnostic and therapeutic context of VCL


  1. Relative involvement of GPIb/IX-vWF axis and GPIIb/IIIa in thrombus growth at high shear rates in the guinea pig. André, P., Hainaud, P., Bal dit Sollier, C., Garfinkel, L.I., Caen, J.P., Drouet, L.O. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  2. Efficacy of the novel calcium antagonist R(+)-semotiadil in limiting the ventricular rate during atrial flutter in isolated guinea pig hearts. Schwarzl, I., Stark, U., Brodmann, M., Haiden, U., Tritthart, H.A., Stark, G. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  3. Evidence for a role of collagen synthesis in arterial smooth muscle cell migration. Rocnik, E.F., Chan, B.M., Pickering, J.G. J. Clin. Invest. (1998) [Pubmed]
  4. Confocal laser microscopy of dystrophin localization in guinea pig skeletal muscle fibers. Masuda, T., Fujimaki, N., Ozawa, E., Ishikawa, H. J. Cell Biol. (1992) [Pubmed]
  5. Interaction of alpha-actinin and vinculin with actin: opposite effects on filament network formation. Jockusch, B.M., Isenberg, G. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  6. Microtubule integrity is necessary for the epithelial barrier function of cultured thyroid cell monolayers. Yap, A.S., Stevenson, B.R., Abel, K.C., Cragoe, E.J., Manley, S.W. Exp. Cell Res. (1995) [Pubmed]
  7. Thyroid cell spreading and focal adhesion formation depend upon protein tyrosine phosphorylation and actin microfilaments. Yap, A.S., Keast, J.R., Manley, S.W. Exp. Cell Res. (1994) [Pubmed]
  8. Antithrombotic effect of a recombinant von Willebrand factor, VCL, on nitrogen laser-induced thrombus formation in guinea pig mesenteric arteries. Azzam, K., Garfinkel, L.I., Bal dit Sollier, C., Cisse Thiam, M., Drouet, L. Thromb. Haemost. (1995) [Pubmed]
  9. Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell death. Liu, X., Schnellmann, R.G. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  10. Molecular cloning and chromosome assignment of porcine vinculin gene (VCL). Ponsuksili, S., Schellander, K., Wimmers, K. Anim. Genet. (2002) [Pubmed]
  11. Donor lung preservation: effect of cold preservation fluids on cultured pulmonary endothelial cells. Hall, S.M., Komai, H., Reader, J., Haworth, S.G. Am. J. Physiol. (1994) [Pubmed]
  12. LPP, a LIM protein highly expressed in smooth muscle. Gorenne, I., Nakamoto, R.K., Phelps, C.P., Beckerle, M.C., Somlyo, A.V., Somlyo, A.P. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  13. Vinculin localization and actin stress fibers differ in thyroid cells organized as monolayers or follicles. Yap, A.S., Stevenson, B.R., Waters, M.J., Keast, J.R., Manley, S.W. Cell Motil. Cytoskeleton (1995) [Pubmed]
  14. Evidence for a ternary interaction between alpha-actinin, (meta)vinculin and acidic-phospholipid bilayers. Niggli, V., Gimona, M. Eur. J. Biochem. (1993) [Pubmed]
  15. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling. Wang, X., Gerdes, A.M. J. Mol. Cell. Cardiol. (1999) [Pubmed]
  16. Effect of tropomyosin on the interactions of actin with actin-binding proteins isolated from pig platelets. Prulière, G., d'Albis, A., der Terrossian, E. Eur. J. Biochem. (1986) [Pubmed]
  17. Neonatal pulmonary hypertension prevents reorganisation of the pulmonary arterial smooth muscle cytoskeleton after birth. Hall, S.M., Gorenflo, M., Reader, J., Lawson, D., Haworth, S.G. J. Anat. (2000) [Pubmed]
  18. Restricted tissue distribution of a 37-kD possible adherens junction protein. Chiu, M.L., Jones, J.C., O'Keefe, E.J. J. Cell Biol. (1992) [Pubmed]
  19. Platelet-derived growth factor-induced alterations in vinculin distribution in porcine vascular smooth muscle cells. Herman, B., Roe, M.W., Harris, C., Wray, B., Clemmons, D. Cell Motil. Cytoskeleton (1987) [Pubmed]
  20. Transition of aortic endothelial cells from resting to migrating cells is associated with three sequential patterns of microfilament organization. Lee, T.Y., Rosenthal, A., Gotlieb, A.I. J. Vasc. Res. (1996) [Pubmed]
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