The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

B2R  -  bradykinin type 2 receptor

Sus scrofa

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of B2R


High impact information on B2R

  • This potentiation was prevented by serine protease inhibitors and was antagonized by B2-receptor blockade [2].
  • The increase in RL induced by cold air after L-NAME was abolished by the tachykinin NK2-receptor antagonist SR 48968 or the kinin B2-receptor antagonist, HOE 140 [3].
  • With the new tracer as label, the B2 receptor antagonists D-Arg0-[Hyp3,Thi5,D-Tic7,Oic8]BK and D-Arg0-[Hyp3,Thi5,8,D-Phe7]BK recognized both binding sites with very high affinity in guinea pig ileum membranes, classifying these sites as B2 receptors [4].
  • In the central airways, the contribution of sensory neuropeptides to the bradykinin response is greater than that caused by direct stimulation of the B2 receptor on the endothelium at the postcapillary venule of the bronchial circulation [5].
  • D-Arg[Hyp3,D-Phe7]-Bk (NPC567) and D-arg[Hyp3,Thi5,8,D-Phe7]-Bk (NPC349), B2 receptor antagonists, were weak inhibitors of Bk-induced bronchoconstriction in vivo and were virtually inactive as antagonists of Bk-induced airway smooth muscle contraction [6].

Biological context of B2R


Anatomical context of B2R


Associations of B2R with chemical compounds

  • Both contraction and relaxation by bradykinin were blocked by the kinin B2 receptor antagonist, HOE 140 [16].
  • We also studied the effects of a B1 receptor agonist and antagonist, a B2 receptor antagonist, and the cyclooxygenase inhibitor indomethacin [17].
  • NPC 567 (DArg[Hyp3,DPhe7]-bradykinin), a B2 receptor antagonist, had no effect on bradykinin-induced 45Ca2+ efflux, but abolished prostaglandin synthesis [17].
  • The A(1-7)-induced relaxation was not affected by AT1 or AT2 receptor blockade or cyclo-oxygenase inhibition, but was attenuated by the B2 receptor antagonist, Hoe 140, and augmented by the angiotensin-converting enzyme (ACE) inhibitor, quinaprilat [18].
  • The pressor response to IP BK was reduced by concomitant IP injection of lidocaine or of D-Arg[Hyp3,D-Phe7,Leu8]BK, a B2 receptor antagonist [19].

Analytical, diagnostic and therapeutic context of B2R


  1. Mechanisms underlying lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris sphincter in vitro. El Sayah, M., Medeiros, R., Fernandes, E.S., Campos, M.M., Calixto, J.B. Mol. Pharmacol. (2006) [Pubmed]
  2. Bradykinin B2-receptor activation augments norepinephrine exocytosis from cardiac sympathetic nerve endings. Mediation by autocrine/paracrine mechanisms. Seyedi, N., Win, T., Lander, H.M., Levi, R. Circ. Res. (1997) [Pubmed]
  3. Endogenous nitric oxide inhibits bronchoconstriction induced by cold-air inhalation in guinea pigs: role of kinins. Yoshihara, S., Nadel, J.A., Figini, M., Emanueli, C., Pradelles, P., Geppetti, P. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  4. Discrimination between putative bradykinin B2 receptor subtypes in guinea pig ileum smooth muscle membranes with a selective, iodinatable, bradykinin analogue. Liebmann, C., Bossé, R., Escher, E. Mol. Pharmacol. (1994) [Pubmed]
  5. Bradykinin-induced airway inflammation. Contribution of sensory neuropeptides differs according to airway site. Nakajima, N., Ichinose, M., Takahashi, T., Yamauchi, H., Igarashi, A., Miura, M., Inoue, H., Takishima, T., Shirato, K. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  6. Evidence for a pulmonary B3 bradykinin receptor. Farmer, S.G., Burch, R.M., Meeker, S.A., Wilkins, D.E. Mol. Pharmacol. (1989) [Pubmed]
  7. Endogenous B1 receptor mediated hypotension produced by contact system activation in the presence of endotoxemia. Schmid, A., Eich-Rathfelder, S., Whalley, E.T., Cheronis, J.C., Scheuber, H.P., Fritz, H., Siebeck, M. Immunopharmacology (1998) [Pubmed]
  8. Role of bradykinin B2 receptors in the modulation of the peristaltic reflex of the guinea pig isolated ileum. Chan, S.K., Rudd, J.A. Eur. J. Pharmacol. (2006) [Pubmed]
  9. ACE inhibitor and AT1 antagonist blockade of deformation-induced gene expression in the rabbit jugular vein through B2 receptor activation. Lauth, M., Cattaruzza, M., Hecker, M. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  10. Free radicals generated by xanthine/xanthine oxidase system augment nitric oxide synthase (NOS) and cyclooxygenase (COX)-independent component of bradykinin-induced vasodilatation in the isolated guinea pig heart. Kozlovski, V.I., Olszanecki, R., Chlopicki, S. Pharmacological reports : PR. (2006) [Pubmed]
  11. Angiotensin 1-7 induces bradykinin-mediated relaxation in porcine coronary artery. Gorelik, G., Carbini, L.A., Scicli, A.G. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  12. MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized guinea pigs. Valenti, C., Cialdai, C., Giuliani, S., Lecci, A., Tramontana, M., Meini, S., Quartara, L., Maggi, C.A. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  13. Involvement of bradykinin B1 and B2 receptors in pulmonary leukocyte accumulation induced by Sephadex beads in guinea pigs. Perron, M.S., Gobeil, F., Pelletier, S., Regoli, D., Sirois, P. Eur. J. Pharmacol. (1999) [Pubmed]
  14. Autoradiographic localization of [125I-Tyr8]-bradykinin receptor binding sites in the guinea pig spinal cord. Lopes, P., Kar, S., Tousignant, C., Regoli, D., Quirion, R., Couture, R. Synapse (1993) [Pubmed]
  15. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Sylvin, H., van der Ploeg, I., Alving, K. Inflamm. Res. (2001) [Pubmed]
  16. Evidence that epithelium-derived relaxing factor released by bradykinin in the guinea pig trachea is nitric oxide. Figini, M., Ricciardolo, F.L., Javdan, P., Nijkamp, F.P., Emanueli, C., Pradelles, P., Folkerts, G., Geppetti, P. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  17. Evidence that cultured airway smooth muscle cells contain bradykinin B2 and B3 receptors. Farmer, S.G., Ensor, J.E., Burch, R.M. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
  18. Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Pörsti, I., Bara, A.T., Busse, R., Hecker, M. Br. J. Pharmacol. (1994) [Pubmed]
  19. Mechanism of the pressor response to intraperitoneal injection of bradykinin in guinea pigs. Beauchamp, J.F., Lemieux, M., Drapeau, G., Rioux, F. Peptides (1991) [Pubmed]
  20. Effect of combined B1 and B2 kinin receptor blockade in porcine endotoxin shock. Siebeck, M., Spannagl, E., Schorr, M., Stumpf, B., Fritz, H., Whalley, E.T., Cheronis, J.C. Immunopharmacology (1996) [Pubmed]
  21. Angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the B2 kinin receptor within the plasma membrane of native endothelial cells. Benzing, T., Fleming, I., Blaukat, A., Müller-Esterl, W., Busse, R. Circulation (1999) [Pubmed]
WikiGenes - Universities