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MeSH Review

Leukemia, B-Cell, Acute

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Disease relevance of Leukemia, B-Cell, Acute


High impact information on Leukemia, B-Cell, Acute


Chemical compound and disease context of Leukemia, B-Cell, Acute

  • Of 14 amino acid residues tested at position 158 of cyt b all but alanine and serine resulted in a marked decrease of cyt bc1 activity and failed to support photosynthetic growth of R. capsulatus [10].
  • PATIENTS AND METHODS: From September 1992 to June 1997, 26 consecutive adults with newly diagnosed untreated B-ALL received hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD) [11].
  • Patients with stage I and II disease resected received three, while all others received six, 5-day therapy courses (dexamethasone, methotrexate [MTX] 0.5 g/m2 [5 g/m2 for stage IV and B-ALL], and intrathecal [IT] therapy in each course, plus ifosfamide, cytarabine, and etoposide alternating with cyclophosphamide and doxorubicin) [12].
  • Nausea was recorded on day 1 by one patient in group A, and two in group B, and on days 2 to 5 by three patients in group A, and by seven in group B. All patients were alert during treatment with ondansetron and there was no dystonia [13].
  • Extensive similarity in sequence, taken to indicate similarity in secondary and tertiary structure, is seen between the mammalian enzyme and yeast hexokinase isozymes A and B. All residues critical for binding glucose to the yeast enzyme are conserved in brain hexokinase [14].

Biological context of Leukemia, B-Cell, Acute


Anatomical context of Leukemia, B-Cell, Acute

  • Lymphoblasts from adult patients with precursor B ALL were cultured on bone marrow stroma and were treated with CCI-779, a second generation MTI [20].
  • These data provide the rationale for infusing UCB-derived CD19-specific T cells after UCBT to reduce the incidence of CD19+ B-ALL relapse [21].
  • 7. Our data are compatible with the hypothesis that selected HOX-2 genes play a role in the IL-2/IL-1 beta-induced activation and/or proliferation of normal NK lymphocytes and possibly in the oncogenetic process of some T- and B-ALL [22].
  • B29 (CD79b) was expressed in the cytoplasm in 65% (15/23) of pre-B-ALL and in 14% (4/28) common-ALL but it was detected in the cell membrane in only three cases of mature B-ALL, being negative in all other B lineage subtypes ALL [23].
  • In the lymphoblastic leukaemia cell lines, MOLT-3, HSB, and B-ALL, supra-additive effects were observed for ICRF-154 in combination with amsacrine, bleomycin, doxorubicin, and etoposide [24].

Gene context of Leukemia, B-Cell, Acute

  • Furthermore our data show that although inactivation of MTS1 by deletion is common, inactivation of MTS2 by a combination of deletion and hypermethylation is more frequent in both B-ALL (20/29, 69%) and T-ALL (17/17, 100%) [25].
  • We investigated the ARF-MDM-2-p53 pathway in tumor specimen from 24 children with sporadic BL/B-ALL [26].
  • On pre-culture cells, CD33 expression was frequently observed in CD19+, CD10- B-precursor ALL, and CD14 was expressed only on the cells from B-precursor ALL expressing CD19, CD10 and CD20, and B-ALL [27].
  • After 7 days of liquid culture DNA-synthesis was induced in six of 10 cALL, three of five B-ALL, and two of seven T-ALL samples by IL-7 or IL-3 or both [28].
  • In case of precursor B-ALL we recommend including the IGLJ6 probe for the detection of rearrangements to J-Clambda6 [18].

Analytical, diagnostic and therapeutic context of Leukemia, B-Cell, Acute


  1. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Hu, Y., Liu, Y., Pelletier, S., Buchdunger, E., Warmuth, M., Fabbro, D., Hallek, M., Van Etten, R.A., Li, S. Nat. Genet. (2004) [Pubmed]
  2. A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia. Dolstra, H., Fredrix, H., Maas, F., Coulie, P.G., Brasseur, F., Mensink, E., Adema, G.J., de Witte, T.M., Figdor, C.G., van de Wiel-van Kemenade, E. J. Exp. Med. (1999) [Pubmed]
  3. p16 gene homozygous deletions in acute lymphoblastic leukemia. Quesnel, B., Preudhomme, C., Philippe, N., Vanrumbeke, M., Dervite, I., Lai, J.L., Bauters, F., Wattel, E., Fenaux, P. Blood (1995) [Pubmed]
  4. Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome. Huettner, C.S., Koschmieder, S., Iwasaki, H., Iwasaki-Arai, J., Radomska, H.S., Akashi, K., Tenen, D.G. Blood (2003) [Pubmed]
  5. CD34(+) acute myeloid and lymphoid leukemic blasts can be induced to differentiate into dendritic cells. Cignetti, A., Bryant, E., Allione, B., Vitale, A., Foa, R., Cheever, M.A. Blood (1999) [Pubmed]
  6. Irreversible deformation of the spectrin-actin lattice in irreversibly sickled cells. Lux, S.E., John, K.M., Karnovsky, M.J. J. Clin. Invest. (1976) [Pubmed]
  7. Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Lacy, E.R., Ito, S. Gastroenterology (1982) [Pubmed]
  8. Translocation of c-myc into the immunoglobulin heavy-chain locus in human acute B-cell leukemia. A molecular analysis. Carè, A., Cianetti, L., Giampaolo, A., Sposi, N.M., Zappavigna, V., Mavilio, F., Alimena, G., Amadori, S., Mandelli, F., Peschle, C. EMBO J. (1986) [Pubmed]
  9. Bim is a suppressor of Myc-induced mouse B cell leukemia. Egle, A., Harris, A.W., Bouillet, P., Cory, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  10. Size of the amino acid side chain at position 158 of cytochrome b is critical for an active cytochrome bc1 complex and for photosynthetic growth of Rhodobacter capsulatus. Atta-Asafo-Adjei, E., Daldal, F. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  11. Hyper-CVAD program in Burkitt's-type adult acute lymphoblastic leukemia. Thomas, D.A., Cortes, J., O'Brien, S., Pierce, S., Faderl, S., Albitar, M., Hagemeister, F.B., Cabanillas, F.F., Murphy, S., Keating, M.J., Kantarjian, H. J. Clin. Oncol. (1999) [Pubmed]
  12. Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Münster Group. Reiter, A., Schrappe, M., Parwaresch, R., Henze, G., Müller-Weihrich, S., Sauter, S., Sykora, K.W., Ludwig, W.D., Gadner, H., Riehm, H. J. Clin. Oncol. (1995) [Pubmed]
  13. Prevention of cyclophosphamide/cytarabine-induced emesis with ondansetron in children with leukemia. Carden, P.A., Mitchell, S.L., Waters, K.D., Tiedemann, K., Ekert, H. J. Clin. Oncol. (1990) [Pubmed]
  14. The complete amino acid sequence of the catalytic domain of rat brain hexokinase, deduced from the cloned cDNA. Schwab, D.A., Wilson, J.E. J. Biol. Chem. (1988) [Pubmed]
  15. Gradient of E2A activity in B-cell development. Herblot, S., Aplan, P.D., Hoang, T. Mol. Cell. Biol. (2002) [Pubmed]
  16. Methylation of the IL-12Rbeta2 gene as novel tumor escape mechanism for pediatric B-acute lymphoblastic leukemia cells. Airoldi, I., Cocco, C., Di Carlo, E., Disarò, S., Ognio, E., Basso, G., Pistoia, V. Cancer Res. (2006) [Pubmed]
  17. Adult precursor B-ALL with BCR/ABL gene rearrangements displays a unique immunophenotype based on the pattern of CD10, CD34, CD13 and CD38 expresssion. Tabernero, M.D., Bortoluci, A.M., Alaejos, I., López-Berges, M.C., Rasillo, A., García-Sanz, R., García, M., Sayagués, J.M., González, M., Mateo, G., San Miguel, J.F., Orfao, A. Leukemia (2001) [Pubmed]
  18. Immunoglobulin lambda isotype gene rearrangements in B cell malignancies. Tümkaya, T., van der Burg, M., Garcia Sanz, R., Gonzalez Diaz, M., Langerak, A.W., San Miguel, J.F., van Dongen, J.J. Leukemia (2001) [Pubmed]
  19. VLA-4 affinity correlates with peripheral blood white cell count and DNA content in patients with precursor B-ALL. Blenc, A.M., Chiagev, A., Sklar, L., Larson, R.S. Leukemia (2003) [Pubmed]
  20. The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Teachey, D.T., Obzut, D.A., Cooperman, J., Fang, J., Carroll, M., Choi, J.K., Houghton, P.J., Brown, V.I., Grupp, S.A. Blood (2006) [Pubmed]
  21. Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy. Serrano, L.M., Pfeiffer, T., Olivares, S., Numbenjapon, T., Bennitt, J., Kim, D., Smith, D., McNamara, G., Al-Kadhimi, Z., Rosenthal, J., Forman, S.J., Jensen, M.C., Cooper, L.J. Blood (2006) [Pubmed]
  22. Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes. Petrini, M., Quaranta, M.T., Testa, U., Samoggia, P., Tritarelli, E., Carè, A., Cianetti, L., Valtieri, M., Barletta, C., Peschle, C. Blood (1992) [Pubmed]
  23. Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia. Astsaturov, I.A., Matutes, E., Morilla, R., Seon, B.K., Mason, D.Y., Farahat, N., Catovsky, D. Leukemia (1996) [Pubmed]
  24. The effects of ICRF-154 in combination with other anticancer agents in vitro. Kano, Y., Narita, T., Suzuki, K., Akutsu, M., Suda, K., Sakamoto, S., Miura, Y. Br. J. Cancer (1992) [Pubmed]
  25. Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia. Iravani, M., Dhat, R., Price, C.M. Oncogene (1997) [Pubmed]
  26. Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children. Wilda, M., Bruch, J., Harder, L., Rawer, D., Reiter, A., Borkhardt, A., Woessmann, W. Leukemia (2004) [Pubmed]
  27. In vivo and in vitro expression of myeloid antigens on B-lineage acute lymphoblastic leukemia cells. Hara, J., Kawa-Ha, K., Yumura-Yagi, K., Kurahashi, H., Tawa, A., Ishihara, S., Inoue, M., Murayama, N., Okada, S. Leukemia (1991) [Pubmed]
  28. Effects of recombinant human IL-7 on blast cell proliferation in acute lymphoblastic leukemia. Eder, M., Ottmann, O.G., Hansen-Hagge, T.E., Bartram, C.R., Gillis, S., Hoelzer, D., Ganser, A. Leukemia (1990) [Pubmed]
  29. Cyclin E overexpression in relapsed adult acute lymphoblastic leukemias of B-cell lineage. Scuderi, R., Palucka, K.A., Pokrovskaja, K., Björkholm, M., Wiman, K.G., Pisa, P. Blood (1996) [Pubmed]
  30. Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications. Macy, E.M., Hayes, T.E., Tracy, R.P. Clin. Chem. (1997) [Pubmed]
  31. Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia. Thomas, D.A., Faderl, S., O'Brien, S., Bueso-Ramos, C., Cortes, J., Garcia-Manero, G., Giles, F.J., Verstovsek, S., Wierda, W.G., Pierce, S.A., Shan, J., Brandt, M., Hagemeister, F.B., Keating, M.J., Cabanillas, F., Kantarjian, H. Cancer (2006) [Pubmed]
  32. Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type. Resar, L.M., Phillips, P.C., Kastan, M.B., Leventhal, B.G., Bowman, P.W., Civin, C.I. Cancer (1993) [Pubmed]
  33. Non-radiolabelled PCR consensus primers and automatic sequencing enable rapid identification of tumor-specific V(H) CDR3 in aggressive B-cell malignancies. Pession, A., Tonelli, R., Canderan, G., Bendandi, M., Rosolen, A., Basso, K., Basso, G., Locatelli, F., Zabalegui, N., Paolucci, G. Leuk. Lymphoma (2003) [Pubmed]
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