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Gene Review

EVL  -  Enah/Vasp-like

Homo sapiens

Synonyms: Ena/VASP-like protein, Ena/vasodilator-stimulated phosphoprotein-like, RNB6
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Disease relevance of EVL


High impact information on EVL

  • Two isoforms, EVL and EVL-I, were highly expressed in hematopoietic cells of thymus and spleen [5].
  • We show strong cooperative binding of two profilin dimers on the polyproline sequence of EVL [5].
  • Like the other family members, EVL localized to focal adhesions and the leading edge of lamellipodia when expressed in fibroblasts [5].
  • These data suggest that the function of EVL could be modulated in a complex manner by its interactions with multiple ligands and through phosphorylation by cyclic nucleotide dependent kinases [5].
  • In CD3-activated T-cells, EVL was found in F-actin-rich patches and at the distal tips of the microspikes that formed on the activated side of the T-cells [5].

Chemical compound and disease context of EVL

  • Then the residual varices around the ligated portion were sclerosed by ethanolamine oleate and the injected vessel was ligated using a pneumo-activated EVL device (EISL) [6].

Biological context of EVL

  • Using yeast two-hybrid screening, we have identified EVL [Enabled/VASP (vasodilator-stimulated phosphoprotein)-like protein] as a new potential partner of the alphaII-spectrin SH3 domain [7].
  • Database search revealed this gene as a rat homologue of the murine EVL, a member of Ena/VASP protein family that is implicated to be involved in the control of cell motility through actin filament assembly by their GP5 motifs [8].
  • Although the precise characterization of EVL was not reported, our Northern blot and immunoblot analyses demonstrated that RNB6 expression in the brain gradually increases during embryonic development, reaches maximum at postnatal day 1 and decreases thereafter [8].
  • Studies of tissue distribution revealed the expression of RNB6 not only in the brain but also in the spleen, thymus and testis [8].

Anatomical context of EVL

  • In these cells over-expressing EVL, the alphaII-spectrin membrane labelling lagged behind EVL staining in lamellipodia and filopodia, with co-localization of these two stains in the contact area [7].
  • In kidney epithelial and COS-7 cells, we demonstrated the co-immunoprecipitation of the alphaII-spectrin chain with over-expressed EVL [7].
  • In kidney epithelial cell lines, focused co-localization of spectrin with expressed EVL was observed in the membrane of the lateral domain, where the cell-cell contacts are reinforced.Conclusions [7].
  • Moreover, we describe an in vitro interaction between Tes and EVL, and a co-localization of these two proteins at focal adhesions [9].
  • After EVL-PSE, the flow rate and velocity of MPV was significantly reduced (P<0.05), as well as the flow rate of the LGV and azygos vein [10].

Regulatory relationships of EVL

  • The EVL protein alone promotes single-stranded DNA annealing, and the recombination activities of the EVL protein are further enhanced by the RAD51B protein [11].

Analytical, diagnostic and therapeutic context of EVL


  1. The usefulness of ultrasonic microprobe imaging for endoscopic variceal ligation. Nagamine, N., Ido, K., Ueno, N., Kimura, K., Kawamata, T., Kawada, H., Hirasawa, T., Suzuki, T., Kubo, H., Tokumaru, K., Seki, M. Am. J. Gastroenterol. (1996) [Pubmed]
  2. A prospective randomized controlled trial of sclerotherapy vs ligation in the prophylactic treatment of high-risk esophageal varices. Svoboda, P., Kantorová, I., Ochmann, J., Kozumplík, L., Marsová, J. Surgical endoscopy. (1999) [Pubmed]
  3. Endoscopic ultrasonography in the treatment of oesophageal varices by endoscopic sclerotherapy and band ligation: do we need it? Pontes, J.M., Leitão, M.C., Portela, F.A., Rosa, A.M., Ministro, P., Freitas, D.S. European journal of gastroenterology & hepatology. (1995) [Pubmed]
  4. Endoscopic elastic band ligation for active variceal hemorrhage. Stiegmann, G.V., Goff, J.S., Sun, J.H., Wilborn, S. The American surgeon. (1989) [Pubmed]
  5. cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. Lambrechts, A., Kwiatkowski, A.V., Lanier, L.M., Bear, J.E., Vandekerckhove, J., Ampe, C., Gertler, F.B. J. Biol. Chem. (2000) [Pubmed]
  6. Endoscopic management of gastric varices using a detachable snare and simultaneous endoscopic sclerotherapy and O-ring ligation. Yoshida, T., Harada, T., Shigemitsu, T., Takeo, Y., Miyazaki, S., Okita, K. J. Gastroenterol. Hepatol. (1999) [Pubmed]
  7. Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization. Bournier, O., Kroviarski, Y., Rotter, B., Nicolas, G., Lecomte, M.C., Dhermy, D. Biol. Cell (2006) [Pubmed]
  8. Differential display cloning of a novel rat cDNA (RNB6) that shows high expression in the neonatal brain revealed a member of Ena/VASP family. Ohta, S., Mineta, T., Kimoto, M., Tabuchi, K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  9. AlphaII-spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contacts. Rotter, B., Bournier, O., Nicolas, G., Dhermy, D., Lecomte, M.C. Biochem. J. (2005) [Pubmed]
  10. Therapeutic effects of endoscopic variceal ligation combined with partial splenic embolization for portal hypertension. Xu, R.Y., Liu, B., Lin, N. World J. Gastroenterol. (2004) [Pubmed]
  11. Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL. Takaku, M., Machida, S., Hosoya, N., Nakayama, S., Takizawa, Y., Sakane, I., Shibata, T., Miyagawa, K., Kurumizaka, H. J. Biol. Chem. (2009) [Pubmed]
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