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Gene Review

Blmpf1  -  bleomycin-induced pulmonary fibrosis 1

Mus musculus

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Chemical compound and disease context of Blmpf1


Biological context of Blmpf1


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  1. Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice. Haston, C.K., Wang, M., Dejournett, R.E., Zhou, X., Ni, D., Gu, X., King, T.M., Weil, M.M., Newman, R.A., Amos, C.I., Travis, E.L. Hum. Mol. Genet. (2002) [Pubmed]
  2. Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines. Cannarile, L., Fallarino, F., Agostini, M., Cuzzocrea, S., Mazzon, E., Vacca, C., Genovese, T., Migliorati, G., Ayroldi, E., Riccardi, C. Blood (2006) [Pubmed]
  3. Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis. Haston, C.K., Travis, E.L. Cancer Res. (1997) [Pubmed]
  4. Effect of superoxide dismutase on bleomycin-induced dermal sclerosis: implications for the treatment of systemic sclerosis. Yamamoto, T., Takagawa, S., Katayama, I., Mizushima, Y., Nishioka, K. J. Invest. Dermatol. (1999) [Pubmed]
  5. Analysis of mast cell function in biological responses not involving IgE. Galli, S.J., Wershil, B.K., Mekori, Y.A. Int. Arch. Allergy Appl. Immunol. (1987) [Pubmed]
  6. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. Daniels, C.E., Wilkes, M.C., Edens, M., Kottom, T.J., Murphy, S.J., Limper, A.H., Leof, E.B. J. Clin. Invest. (2004) [Pubmed]
  7. IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis. Huang, M., Sharma, S., Zhu, L.X., Keane, M.P., Luo, J., Zhang, L., Burdick, M.D., Lin, Y.Q., Dohadwala, M., Gardner, B., Batra, R.K., Strieter, R.M., Dubinett, S.M. J. Clin. Invest. (2002) [Pubmed]
  8. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. Kuwano, K., Hagimoto, N., Kawasaki, M., Yatomi, T., Nakamura, N., Nagata, S., Suda, T., Kunitake, R., Maeyama, T., Miyazaki, H., Hara, N. J. Clin. Invest. (1999) [Pubmed]
  9. Prevention of bleomycin-induced pulmonary fibrosis after adenovirus-mediated transfer of the bacterial bleomycin resistance gene. Tran, P.L., Weinbach, J., Opolon, P., Linares-Cruz, G., Reynes, J.P., Grégoire, A., Kremer, E., Durand, H., Perricaudet, M. J. Clin. Invest. (1997) [Pubmed]
  10. Angiotensin II antagonism fails to ameliorate bleomycin-induced pulmonary fibrosis in mice. Keogh, K.A., Standing, J., Kane, G.C., Terzic, A., Limper, A.H. Eur. Respir. J. (2005) [Pubmed]
  11. ICAM-1 mediates lung leukocyte recruitment but not pulmonary fibrosis in a murine model of bleomycin-induced lung injury. Matsuse, T., Teramoto, S., Katayama, H., Sudo, E., Ekimoto, H., Mitsuhashi, H., Uejima, Y., Fukuchi, Y., Ouchi, Y. Eur. Respir. J. (1999) [Pubmed]
  12. Smad3 as a mediator of the fibrotic response. Flanders, K.C. International journal of experimental pathology. (2004) [Pubmed]
  13. Bleomycin-induced pulmonary fibrosis in genetically mast cell-deficient WBB6F1-W/Wv mice and mechanism of the suppressive effect of tranilast, an antiallergic drug inhibiting mediator release from mast cells, on fibrosis. Mori, H., Kawada, K., Zhang, P., Uesugi, Y., Sakamoto, O., Koda, A. Int. Arch. Allergy Appl. Immunol. (1991) [Pubmed]
  14. Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions. Haston, C.K., Tomko, T.G., Godin, N., Kerckhoff, L., Hallett, M.T. J. Med. Genet. (2005) [Pubmed]
  15. Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis. Suzuki, H., Aoshiba, K., Yokohori, N., Nagai, A. Cancer Res. (2003) [Pubmed]
  16. Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. Beller, T.C., Maekawa, A., Friend, D.S., Austen, K.F., Kanaoka, Y. J. Biol. Chem. (2004) [Pubmed]
  17. Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. Keerthisingam, C.B., Jenkins, R.G., Harrison, N.K., Hernandez-Rodriguez, N.A., Booth, H., Laurent, G.J., Hart, S.L., Foster, M.L., McAnulty, R.J. Am. J. Pathol. (2001) [Pubmed]
  18. Bleomycin-induced injury and metaplasia of alveolar type 2 cells. Relationship of cellular responses to drug presence in the lung. Adamson, I.Y., Bowden, D.H. Am. J. Pathol. (1979) [Pubmed]
  19. Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguaiaretic acid. The role of alveolar macrophage activation and mediator production. Phan, S.H., Kunkel, S.L. Am. J. Pathol. (1986) [Pubmed]
  20. Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamide-sensitive T cells. Schrier, D.J., Phan, S.H. Am. J. Pathol. (1984) [Pubmed]
  21. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis. Keane, M.P., Belperio, J.A., Moore, T.A., Moore, B.B., Arenberg, D.A., Smith, R.E., Burdick, M.D., Kunkel, S.L., Strieter, R.M. J. Immunol. (1999) [Pubmed]
  22. GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. Moore, B.B., Coffey, M.J., Christensen, P., Sitterding, S., Ngan, R., Wilke, C.A., McDonald, R., Phare, S.M., Peters-Golden, M., Paine, R., Toews, G.B. J. Immunol. (2000) [Pubmed]
  23. Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin. Kolb, M., Margetts, P.J., Galt, T., Sime, P.J., Xing, Z., Schmidt, M., Gauldie, J. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  24. Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice. Aono, Y., Nishioka, Y., Inayama, M., Ugai, M., Kishi, J., Uehara, H., Izumi, K., Sone, S. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  25. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Zhao, J., Shi, W., Wang, Y.L., Chen, H., Bringas, P., Datto, M.B., Frederick, J.P., Wang, X.F., Warburton, D. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  26. Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation. Charbeneau, R.P., Christensen, P.J., Chrisman, C.J., Paine, R., Toews, G.B., Peters-Golden, M., Moore, B.B. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  27. Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma. Kim, J.H., Kim, H.Y., Kim, S., Chung, J.H., Park, W.S., Chung, D.H. Am. J. Pathol. (2005) [Pubmed]
  28. C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metalloproteinases. Okuma, T., Terasaki, Y., Kaikita, K., Kobayashi, H., Kuziel, W.A., Kawasuji, M., Takeya, M. J. Pathol. (2004) [Pubmed]
  29. A Novel I{kappa}B Kinase-beta Inhibitor Ameliorates Bleomycin-induced Pulmonary Fibrosis in Mice. Inayama, M., Nishioka, Y., Azuma, M., Muto, S., Aono, Y., Makino, H., Tani, K., Uehara, H., Izumi, K., Itai, A., Sone, S. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  30. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Belperio, J.A., Dy, M., Burdick, M.D., Xue, Y.Y., Li, K., Elias, J.A., Keane, M.P. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  31. Skeletal muscle targeting in vivo electroporation-mediated HGF gene therapy of bleomycin-induced pulmonary fibrosis in mice. Umeda, Y., Marui, T., Matsuno, Y., Shirahashi, K., Iwata, H., Takagi, H., Matsumoto, K., Nakamura, T., Kosugi, A., Mori, Y., Takemura, H. Lab. Invest. (2004) [Pubmed]
  32. Increased type I procollagen mRNA transcripts in the lungs of mice during the development of bleomycin-induced fibrosis. Shahzeidi, S., Jeffery, P.K., Laurent, G.J., McAnulty, R.J. Eur. Respir. J. (1994) [Pubmed]
  33. Pulmonary platelet trapping induced by bleomycin: correlation with fibrosis and involvement of the beta 2 integrins. Piguet, P.F., Vesin, C. International journal of experimental pathology. (1994) [Pubmed]
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