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Gene Review

CSPG5  -  chondroitin sulfate proteoglycan 5...

Homo sapiens

Synonyms: Acidic leucine-rich EGF-like domain-containing brain protein, CALEB, Chondroitin sulfate proteoglycan 5, NGC, Neuroglycan C
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Disease relevance of CSPG5


High impact information on CSPG5


Biological context of CSPG5


Anatomical context of CSPG5


Associations of CSPG5 with chemical compounds

  • Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain [9].
  • The goal of the present study was to determine whether NGC may activate ErbB tyrosine kinases [1].
  • Neuroglycan C (NGC) is a 150 kDa transmembrane chondroitin sulfate proteoglycan with a 120 kDa core glycoprotein that was originally isolated from the developing rat brain [13].
  • The aims of this study were (1) to investigate culture conditions for optimal IN production by luteinized GC (LGC) from rhesus monkeys and (2) to compare IN and progesterone (P) production by nonluteinized GC (NGC) and LGC in response to putative agonists [14].
  • Dopamine and opioid receptor antagonists attenuated the effect of MAP and morphine respectively on NGC mRNA levels [10].

Regulatory relationships of CSPG5

  • A newly established anti-ErbB3 neutralizing monoclonal antibody (#5C3) almost completely blocked NGC-induced ErbB activation in MDA-MB-453 cells [1].

Other interactions of CSPG5


  1. Neuroglycan C, a novel member of the neuregulin family. Kinugasa, Y., Ishiguro, H., Tokita, Y., Oohira, A., Ohmoto, H., Higashiyama, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Genetic determinants responsible for acquisition of dengue type 2 virus mouse neurovirulence. Bray, M., Men, R., Tokimatsu, I., Lai, C.J. J. Virol. (1998) [Pubmed]
  3. The early pathophysiolic understanding of angina pectoris (Edward Jenner, Caleb Hillier Parry, Alan Burns). Kligfield, P. Am. J. Cardiol. (1982) [Pubmed]
  4. Fas and Fas ligand expression on germinal center type-diffuse large B-cell lymphoma is associated with the clinical outcome. Kojima, Y., Tsurumi, H., Goto, N., Shimizu, M., Kasahara, S., Yamada, T., Kanemura, N., Hara, T., Sawada, M., Saio, M., Yamada, T., Takahashi, T., Tomita, E., Takami, T., Moriwaki, H. Eur. J. Haematol. (2006) [Pubmed]
  5. History of disorders of thyroid dysfunction. Ahmed, A.M., Ahmed, N.H. Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-¿i¿¿¿yah li-sharq al-mutawassi¿. (2005) [Pubmed]
  6. Neuroglycan C Is a Novel Midkine Receptor Involved in Process Elongation of Oligodendroglial Precursor-like Cells. Ichihara-Tanaka, K., Oohira, A., Rumsby, M., Muramatsu, T. J. Biol. Chem. (2006) [Pubmed]
  7. Identification of neurite outgrowth-promoting domains of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, and involvement of phosphatidylinositol 3-kinase and protein kinase C signaling pathways in neuritogenesis. Nakanishi, K., Aono, S., Hirano, K., Kuroda, Y., Ida, M., Tokita, Y., Matsui, F., Oohira, A. J. Biol. Chem. (2006) [Pubmed]
  8. Identification and functions of chondroitin sulfate in the milieu of neural stem cells. Ida, M., Shuo, T., Hirano, K., Tokita, Y., Nakanishi, K., Matsui, F., Aono, S., Fujita, H., Fujiwara, Y., Kaji, T., Oohira, A. J. Biol. Chem. (2006) [Pubmed]
  9. Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain. Aono, S., Tokita, Y., Yasuda, Y., Hirano, K., Yamauchi, S., Shuo, T., Matsui, F., Keino, H., Kashiwai, A., Kawamura, N., Shimada, A., Kishikawa, M., Asai, M., Oohira, A. J. Neurosci. Res. (2006) [Pubmed]
  10. Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain. Ishikawa, K., Nitta, A., Mizoguchi, H., Mohri, A., Murai, R., Miyamoto, Y., Noda, Y., Kitaichi, K., Yamada, K., Nabeshima, T. Int. J. Neuropsychopharmacol. (2006) [Pubmed]
  11. Neuroglycan C, a brain-specific part-time proteoglycan, with a particular multidomain structure. Oohira, A., Shuo, T., Tokita, Y., Nakanishi, K., Aono, S. Glycoconj. J. (2004) [Pubmed]
  12. Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge. Bosch, I., Xhaja, K., Estevez, L., Raines, G., Melichar, H., Warke, R.V., Fournier, M.V., Ennis, F.A., Rothman, A.L. J. Virol. (2002) [Pubmed]
  13. Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module. Yasuda, Y., Tokita, Y., Aono, S., Matsui, F., Ono, T., Sonta, S., Watanabe, E., Nakanishi, Y., Oohira, A. Neurosci. Res. (1998) [Pubmed]
  14. Inhibin production by macaque granulosa cells from pre- and periovulatory follicles: regulation by gonadotropins and prostaglandin E2. Brannian, J.D., Stouffer, R.L., Molskness, T.A., Chandrasekher, Y.A., Sarkissian, A., Dahl, K.D. Biol. Reprod. (1992) [Pubmed]
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