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Gene Review

LTBP1  -  latent transforming growth factor beta...

Homo sapiens

Synonyms: LTBP-1, Latent-transforming growth factor beta-binding protein 1, TGF-beta1-BP-1, Transforming growth factor beta-1-binding protein 1
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Disease relevance of LTBP1


High impact information on LTBP1


Chemical compound and disease context of LTBP1


Biological context of LTBP1


Anatomical context of LTBP1


Associations of LTBP1 with chemical compounds

  • The cysteine required for the association between LTBP-1 and beta1-LAP was mapped to Cys33 of beta1-LAP [14].
  • Latent transforming growth factor beta (TGFbeta) binding protein-1 (LTBP1) is an ECM glycoprotein that binds latent TGFbeta and regulates its availability and activity [15].
  • We here report a novel form of human LTBP-1, which is longer in its NH2-terminal part (LTBP-1L) [16].
  • Loss of a consensus heparin binding site by alternative splicing of latent transforming growth factor-beta binding protein-1 [17].
  • Our results indicate that LTBP-1 expression is under the regulation of RA and corticoids in lung fibroblasts [2].

Physical interactions of LTBP1


Co-localisations of LTBP1


Regulatory relationships of LTBP1


Other interactions of LTBP1

  • TGF-beta1 associates with the 3(rd) 8-Cys repeat of LTBP-1 by LAP [21].
  • Immunolocalization data were consistent with the hypothesis that LTBP-1 is a fibrillin-associated protein present in certain tissues but not in others [11].
  • While the domain structure of LTBP-2 is similar to that of the other LTBPs, LTBP-2 possesses unique regions that make it the largest member of the LTBP family [22].
  • In addition, LTBP-1 was found in structures that were heavily labeled for fibronectin [19].
  • In conclusion, TGFbeta3, TGFbeta4, TGFbetai, LTBP1 and LTBP2 may assist the process of dedifferentiation, while TGFbeta1 and beta2 might not be involved in this process [23].

Analytical, diagnostic and therapeutic context of LTBP1


  1. Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1. Gleizes, P.E., Beavis, R.C., Mazzieri, R., Shen, B., Rifkin, D.B. J. Biol. Chem. (1996) [Pubmed]
  2. Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblasts. Weikkolainen, K., Keski-Oja, J., Koli, K. Growth Factors (2003) [Pubmed]
  3. Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma. Karonen, T., Jeskanen, L., Keski-Oja, J. Br. J. Dermatol. (1997) [Pubmed]
  4. In situ expression of transforming growth factor-beta1-3, latent transforming growth factor-beta binding protein and tumor necrosis factor-alpha in liver tissue from patients with chronic hepatitis C. Kinnman, N., Andersson, U., Hultcrantz, R. Scand. J. Gastroenterol. (2000) [Pubmed]
  5. TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Kanzaki, T., Olofsson, A., Morén, A., Wernstedt, C., Hellman, U., Miyazono, K., Claesson-Welsh, L., Heldin, C.H. Cell (1990) [Pubmed]
  6. Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin. Grainger, D.J., Wakefield, L., Bethell, H.W., Farndale, R.W., Metcalfe, J.C. Nat. Med. (1995) [Pubmed]
  7. Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis. van Laethem, J.L., Deviere, J., Resibois, A., Rickaert, F., Vertongen, P., Ohtani, H., Cremer, M., Miyazono, K., Robberecht, P. Gastroenterology (1995) [Pubmed]
  8. Identification of transforming growth factor-beta1-binding protein overexpression in carmustine-resistant glioma cells by MRNA differential display. Norman, S.A., Rhodes, S.N., Treasurywala, S., Hoelzinger, D.B., Rankin Shapiro, J., Scheck, A.C. Cancer (2000) [Pubmed]
  9. Increased immunoreactivity of transforming growth factor-beta in human kidney transplants. Lantz, I., Dimény, E., Larsson, E., Fellström, B., Funa, K. Transpl. Immunol. (1996) [Pubmed]
  10. Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12-->q22. Stenman, G., Sahlin, P., Olofsson, A., Geurts van Kessel, A., Miyazono, K. Cytogenet. Cell Genet. (1994) [Pubmed]
  11. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. Isogai, Z., Ono, R.N., Ushiro, S., Keene, D.R., Chen, Y., Mazzieri, R., Charbonneau, N.L., Reinhardt, D.P., Rifkin, D.B., Sakai, L.Y. J. Biol. Chem. (2003) [Pubmed]
  12. The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium. Gualandris, A., Annes, J.P., Arese, M., Noguera, I., Jurukovski, V., Rifkin, D.B. Mol. Biol. Cell (2000) [Pubmed]
  13. Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo. Dallas, S.L., Keene, D.R., Bruder, S.P., Saharinen, J., Sakai, L.Y., Mundy, G.R., Bonewald, L.F. J. Bone Miner. Res. (2000) [Pubmed]
  14. Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. Saharinen, J., Taipale, J., Keski-Oja, J. EMBO J. (1996) [Pubmed]
  15. New insights into extracellular matrix assembly and reorganization from dynamic imaging of extracellular matrix proteins in living osteoblasts. Sivakumar, P., Czirok, A., Rongish, B.J., Divakara, V.P., Wang, Y.P., Dallas, S.L. J. Cell. Sci. (2006) [Pubmed]
  16. Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix. Olofsson, A., Ichijo, H., Morén, A., ten Dijke, P., Miyazono, K., Heldin, C.H. J. Biol. Chem. (1995) [Pubmed]
  17. Loss of a consensus heparin binding site by alternative splicing of latent transforming growth factor-beta binding protein-1. Oklü, R., Metcalfe, J.C., Hesketh, T.R., Kemp, P.R. FEBS Lett. (1998) [Pubmed]
  18. Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. Nunes, I., Gleizes, P.E., Metz, C.N., Rifkin, D.B. J. Cell Biol. (1997) [Pubmed]
  19. Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils. Taipale, J., Saharinen, J., Hedman, K., Keski-Oja, J. J. Histochem. Cytochem. (1996) [Pubmed]
  20. Independent promoters regulate the expression of two amino terminally distinct forms of latent transforming growth factor-beta binding protein-1 (LTBP-1) in a cell type-specific manner. Koski, C., Saharinen, J., Keski-Oja, J. J. Biol. Chem. (1999) [Pubmed]
  21. Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. Saharinen, J., Keski-Oja, J. Mol. Biol. Cell (2000) [Pubmed]
  22. Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2. Bashir, M.M., Han, M.D., Abrams, W.R., Tucker, T., Ma, R.I., Gibson, M., Ritty, T., Mecham, R., Rosenbloom, J. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  23. In-vitro analysis of the expression of TGFbeta -superfamily-members during chondrogenic differentiation of mesenchymal stem cells and chondrocytes during dedifferentiation in cell culture. Goessler, U.R., Bugert, P., Bieback, K., Deml, M., Sadick, H., Hormann, K., Riedel, F. Cell. Mol. Biol. Lett. (2005) [Pubmed]
  24. Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region. Michel, K., Roth, S., Trautwein, C., Gong, W., Flemming, P., Gressner, A.M. Hepatology (1998) [Pubmed]
  25. Expression of isoforms and splice variants of the latent transforming growth factor beta binding protein (LTBP) in cultured human liver myofibroblasts. Mangasser-Stephan, K., Gartung, C., Lahme, B., Gressner, A.M. Liver (2001) [Pubmed]
  26. The cutaneous microfibrillar apparatus contains latent transforming growth factor-beta binding protein-1 (LTBP-1) and is a repository for latent TGF-beta1. Raghunath, M., Unsöld, C., Kubitscheck, U., Bruckner-Tuderman, L., Peters, R., Meuli, M. J. Invest. Dermatol. (1998) [Pubmed]
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