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Gene Review

SNRPG  -  small nuclear ribonucleoprotein polypeptide G

Homo sapiens

Synonyms: PBSCG, SMG, Sm protein G, Sm-G, SmG, ...
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Disease relevance of SNRPG


Psychiatry related information on SNRPG

  • The SMG and the dorsolateral cerebellum may play a critical role in short-term storage of pitch information and the continuous pitch discrimination necessary for performing this pitch memory task [6].

High impact information on SNRPG

  • CaSm encodes a 133-amino acid open reading frame that contains the two Sm motifs found in the common snRNP proteins, with the greatest homology to the Sm G protein (60% similarity) [7].
  • The common cortical regions in this network are inferior parietal lobule (IPL)/supramarginal gyrus (SMG), anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC) [8].
  • IPL/SMG, ACC, and DLPFC were reliably localized in the MEG median-nerve oddball responses, with IPL/SMG activation significantly preceding ACC and DLPFC activation [8].
  • Using experimental animal models as a guide, the prevertebral superior mesenteric (SMG) and paravertebral superior cervical (SCG) sympathetic ganglia have been examined in a series of adult autopsied diabetic and non-diabetic patients of various ages using histochemical, ultrastructural, morphometric, and immunohistochemical methods [1].
  • Finally, using the two-hybrid screen in yeast, GST pull-downs and co-immunoprecipitations, we identified two potential binding partners for TACC1, LSM7 and SmG [9].

Biological context of SNRPG

  • Furthermore, the selective vulnerability of CG/SMG neurons to diabetes is reflected by increased sensitivity to oxidative stress [10].
  • Nerve crushing caused cell death to limited number of neurons in the CG/SMG [4].
  • The rapid action of plasma from SMG patients argues against an antibody-induced reduction in nAChR numbers; its calcium dependence in one case suggests action by a second messenger that might involve nAChR phosphorylation [11].
  • To address this question, we have analyzed the SMG phenotype in Fgf10 and Fgfr2b heterozygous and null mutant mice [12].
  • Hypoplastic SMGs are seen in Fgf10 and Fgfr2b heterozygotes whereas SMG aplasia is seen in Fgf10 and Fgfr2b null embryos [12].

Anatomical context of SNRPG

  • Sympathetic neurons from the celiac/superior mesenteric ganglia (CG/SMG) develop neuropathic changes in diabetes whereas sympathetic superior cervical ganglion (SCG) neurons do not [10].
  • Such tissues, SMG, ovary, testes, adrenal, pituitary and brain (neurons and glia) are potent sources of RAS components for future studies [13].
  • Activations were detected (P<0.01) bilaterally in the supramarginal gyrus (SMG; BA 40), superior parietal lobule (BA 7), the posterior cingulate gyrus, thalamus, inferior occipitotemporal cortex (BA 19/37), insula, dorsolateral prefrontal cortex (BA 9), anterior cingulate cortex (ACC), medial frontal gyrus (BA 6), premotor area, and cuneus (BA 17) [14].
  • A regions-of-interest analysis found that similar areas (the right secondary auditory cortex, left IFG, left SMG) were activated in ML and the control subjects, to a similar degree, in response to music processing [15].
  • Fixed tissue sections were reacted with soybean agglutinin (SBA) and wheat germ agglutinin (WGA) to detect glycoconjugates, or were stained using an anti-neonatal submandibular gland protein B1 (SMG-B1) antibody to identify serous acinar cells [16].

Associations of SNRPG with chemical compounds

  • However, at low concentrations, menadione had a significantly greater effect (p<0.01) on CG/SMG neurons than SCG neurons [10].
  • Similarly, 8 weeks streptozotocin-induced diabetes resulted in a significant increase (p<0.05) in intensely fluorescent TH-containing CG/SMG neurons but not SCG neurons [10].

Other interactions of SNRPG


Analytical, diagnostic and therapeutic context of SNRPG

  • The sound (SMG) generated by the biceps muscle during isometric exercise at 20, 40, 60, and 80% of maximum voluntary contraction (MVC) up to exhaustion has been recorded by a contact transducer and integrated (iSMG), together with the surface electromyogram (EMG) in eight young untrained men [18].
  • "Analysis of 29 cases evaluated at SMG, Rochester, N.Y." This study analyzed 29 patients with the diagnosis of medulloblastoma evaluated at Strong Memorial Hospital, Rochester, New York. Twenty-three patients received combined (surgery and radiotherapy) treatment [19].
  • A technique for performing antegrade pyelography during nephrotomy is described--puncture with a 21-gauge, 20-cm Cope needle, placement of a 0.018-inch SMG mandril "coat-hanger"-shaped guidewire, with the needle exchanged for a 3-French multi-sidehole dilator [20].


  1. Effect of diabetes and aging on human sympathetic autonomic ganglia. Schmidt, R.E., Plurad, S.B., Parvin, C.A., Roth, K.A. Am. J. Pathol. (1993) [Pubmed]
  2. Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus ("Streptococcus milleri group") are of different clinical importance and are not equally associated with abscess. Claridge, J.E., Attorri, S., Musher, D.M., Hebert, J., Dunbar, S. Clin. Infect. Dis. (2001) [Pubmed]
  3. TC21/R-Ras2 upregulation in esophageal tumorigenesis: potential diagnostic implications. Sharma, R., Sud, N., Chattopadhyay, T.K., Ralhan, R. Oncology (2005) [Pubmed]
  4. Regeneration of the abdominal postganglionic sympathetic system. Yamada, M., Terayama, R., Bando, Y., Kasai, S., Yoshida, S. Neurosci. Res. (2006) [Pubmed]
  5. Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. Schulz, B.L., Sloane, A.J., Robinson, L.J., Sebastian, L.T., Glanville, A.R., Song, Y., Verkman, A.S., Harry, J.L., Packer, N.H., Karlsson, N.G. Biochem. J. (2005) [Pubmed]
  6. Functional anatomy of pitch memory--an fMRI study with sparse temporal sampling. Gaab, N., Gaser, C., Zaehle, T., Jancke, L., Schlaug, G. Neuroimage (2003) [Pubmed]
  7. CaSm: an Sm-like protein that contributes to the transformed state in cancer cells. Schweinfest, C.W., Graber, M.W., Chapman, J.M., Papas, T.S., Baron, P.L., Watson, D.K. Cancer Res. (1997) [Pubmed]
  8. A parietal-frontal network studied by somatosensory oddball MEG responses, and its cross-modal consistency. Huang, M.X., Lee, R.R., Miller, G.A., Thoma, R.J., Hanlon, F.M., Paulson, K.M., Martin, K., Harrington, D.L., Weisend, M.P., Edgar, J.C., Canive, J.M. Neuroimage (2005) [Pubmed]
  9. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. Conte, N., Charafe-Jauffret, E., Delaval, B., Adélaïde, J., Ginestier, C., Geneix, J., Isnardon, D., Jacquemier, J., Birnbaum, D. Oncogene (2002) [Pubmed]
  10. Selective susceptibility of different populations of sympathetic neurons to diabetic neuropathy in vivo is reflected by increased vulnerability to oxidative stress in vitro. Semra, Y.K., Wang, M., Peat, N.J., Smith, N.C., Shotton, H.R., Lincoln, J. Neurosci. Lett. (2006) [Pubmed]
  11. Plasma from patients with seronegative myasthenia gravis inhibit nAChR responses in the TE671/RD cell line. Barrett-Jolley, R., Byrne, N., Vincent, A., Newsom-Davis, J. Pflugers Arch. (1994) [Pubmed]
  12. FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. Jaskoll, T., Abichaker, G., Witcher, D., Sala, F.G., Bellusci, S., Hajihosseini, M.K., Melnick, M. BMC Dev. Biol. (2005) [Pubmed]
  13. Levels of angiotensin and molecular biology of the tissue renin angiotensin systems. Phillips, M.I., Speakman, E.A., Kimura, B. Regul. Pept. (1993) [Pubmed]
  14. Functional magnetic resonance imaging of brain activity in the visual oddball task. Ardekani, B.A., Choi, S.J., Hossein-Zadeh, G.A., Porjesz, B., Tanabe, J.L., Lim, K.O., Bilder, R., Helpern, J.A., Begleiter, H. Brain research. Cognitive brain research. (2002) [Pubmed]
  15. Cortical plasticity in an early blind musician: an fMRl study. Ross, D.A., Olson, I.R., Gore, J.C. Magnetic resonance imaging. (2003) [Pubmed]
  16. Developmental changes of sugar residues and secretory protein in mucous cells of the early postnatal rat parotid gland. Ikeda, R., Aiyama, S. Anat. Rec. (1999) [Pubmed]
  17. Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. Heinrichs, V., Hackl, W., Lührmann, R. J. Mol. Biol. (1992) [Pubmed]
  18. Changes of muscular sound during sustained isometric contraction up to exhaustion. Orizio, C., Perini, R., Veicsteinas, A. J. Appl. Physiol. (1989) [Pubmed]
  19. Medulloblastomas. Castro-Vita, H., Salazar, O.M., Scarantino, C., Rubin, P., De Cova, M. Revista interamericana de radiología. (1980) [Pubmed]
  20. Technique to facilitate percutaneous nephrostomy in non-obstructed kidneys. Braun, S.D., Moore, A.V., Miller, G.A., Ford, K., Dunnick, N.R. Cardiovascular and interventional radiology. (1985) [Pubmed]
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