Disease relevance of Corneal Ulcer

• RESULTS: Patients with scleritis with Wegener granulomatosis had more necrotizing scleritis (79%, P = 0.0001), decrease in vision (79%, P = 0.014), and peripheral ulcerative keratitis (50%, P = 0.0139) than patients with scleritis with the other systemic vasculitic diseases [1].
• We report the first case of methicillin-resistant Staphylococcus aureus (MRSA) ulcerative keratitis after routine bilateral laser in situ keratomileusis [2].
• We treated 12 eyes with Pseudomonas ulcerative keratitis with topical 0.3% Norfloxacin drops (Ranbaxy Laboratories) [3].
• A corneal ulcer, infected with Pseudomonas aeruginosa and complicated by conjunctivitis and endophthalmitis, was treated successfully with systemic administration of ticarcillin and topical application of tobramycin [4].
• BACKGROUND/AIMS: Matrix metalloproteinases (MMPs) accumulate in the tears of patients with active peripheral ulcerative keratitis (PUK) but it is unknown whether these enzymes have a central role in disease progression [5].

High impact information on Corneal Ulcer

• Inhibition of CCR-3 on eosinophils may be a treatment for corneal ulcer in patients with ocular allergy [6].
• CC-chemokine receptor 3: a possible target in treatment of allergy-related corneal ulcer [6].
• PURPOSE: In a previous investigation it was demonstrated that circulating antibodies to a 66-kDa corneal epithelial antigen (BCEA-A) are associated with peripheral ulcerative keratitis (PUK) in patients with Wegener's granulomatosis (WG) [7].
• Corneal epithelial-specific cytokeratin 3 is an autoantigen in Wegener's granulomatosis-associated peripheral ulcerative keratitis [7].
• Peripheral ulcerative keratitis in rheumatoid arthritis: successful use of intravenous cyclophosphamide and comparison of clinical and serological characteristics [8].

Chemical compound and disease context of Corneal Ulcer

• METHODS: Entry criteria into this series included the presence of an infectious corneal ulcer or sterile epithelial defect after the patient used crack cocaine routinely [9].
• One corneal ulcer was successfully treated initially with topical cyclosporine, tissue adhesive, and a bandage contact lens [10].
• To our knowledge, there have been no reports of the use of amikacin for corneal ulcer [11].
• Two years after the last corneal ulcer and no longer taking prednisone, the patient's ocular disease remained quiescent taking azathioprine 175 mg and hydroxychloroquine 400 mg daily [12].
• Compared with placebo, thymine arabinoside reduced ulcerative keratitis but not significantly [13].

Anatomical context of Corneal Ulcer

• RESULTS: After using the chlorhexidine and propamidine eyedrops for 8 weeks, the patient developed a near total loss of the corneal epithelium and a progressive ulcerative keratitis, which eventually required penetrating keratoplasty [14].

Gene context of Corneal Ulcer

• Active MMP-9 was detected in mild corneal ulcer cases and mild ocular burn cases [15].
• Eotaxin has been found in tears of severe allergic patients with corneal ulcer [16].
• AIM: Peripheral ulcerative keratitis (PUK) is an ocular manifestation of rheumatoid arthritis and other similar systemic diseases [17].
• The serum level of retinol, RBP, prealbumin and albumin were generally diminished in cases of dendritic corneal ulcer [18].
• WG patients with peripheral ulcerative keratitis (PUK) had a significant association with anti-BCEA-A antibodies when compared with healthy control subjects (50%, P < 10(-6)) [19].

Analytical, diagnostic and therapeutic context of Corneal Ulcer

• A 57-year-old man was treated for a corneal ulcer with a penetrating keratoplasty, followed by six weeks of a regimen of 4 to 8 mg of dexamethasone injected subconjunctivally daily [20].
• The peripheral ulcerative keratitis was unresponsive to all routine treatment modalities, but it finally responded to immunosuppression by cyclophosphamide, given orally [21].
• METHODS: A 23-year-old white woman in good health had been wearing silicone hydrogel (lotrafilcon A) soft contact lenses continuously for 26 days when she was examined for a corneal ulcer in her left eye [22].

References