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Gene Review

Chrdl1  -  chordin-like 1

Mus musculus

Synonyms: BB139951, CHL, CHL1, Chordin-like protein 1, Neuralin-1, ...
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Disease relevance of Chrdl1


High impact information on Chrdl1

  • Deep layer pyramidal neurons of CHL1-minus mice were shifted to lower laminar positions in the visual and somatosensory cortex and developed misoriented, often inverted apical dendrites [4].
  • Impaired migration of CHL1-minus cortical neurons was suggested by strikingly slower rates of radial migration in cortical slices, failure to potentiate integrin-dependent haptotactic cell migration in vitro, and accumulation of migratory cells in the intermediate and ventricular/subventricular zones in vivo [4].
  • We show that the neural cell recognition molecule Close Homolog of L1 (CHL1) is required for neuronal positioning and dendritic growth of pyramidal neurons in the posterior region of the developing mouse neocortex [4].
  • Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death [5].
  • Taken together, we propose that ADAM8 plays an important role in physiological and pathological cell interactions by a specific release of functional CHL1 from the cell surface [5].

Biological context of Chrdl1

  • A novel chordin-like protein inhibitor for bone morphogenetic proteins expressed preferentially in mesenchymal cell lineages [6].
  • Stable expression of COX-2 in CHL (Chang liver) cells induced proliferation, with an increase in the proportion of cells in S-phase, but no other significant changes in cell-cycle distribution [7].

Anatomical context of Chrdl1


Associations of Chrdl1 with chemical compounds

  • Here we describe that ADAM8, a member of the family of metalloprotease disintegrins cleaves a CHL1-Fc fusion protein in vitro at two sites corresponding to release of the extracellular domain of CHL1 in fibronectin (FN) domains II (125 kDa) and V (165 kDa), inhibited by batimastat (BB-94) [5].
  • Chordin-like cysteine-rich repeats (CRs) are conserved domains present in an expanding family of secreted proteins that associate with members of the TGF beta superfamily [9].
  • However, there was no therapeutic gain for the combined treatment with DDP on RIF-1, with CCNU or BCNU on KHT, or with CHL on either RIF-1 or KHT [10].

Other interactions of Chrdl1

  • Interestingly, the spatiotemporal expression patterns of CHL were distinct from those of chordin in many areas examined [6].


  1. Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft für Umwelt-Mutations-forschung. Miller, B., Pötter-Locher, F., Seelbach, A., Stopper, H., Utesch, D., Madle, S. Mutat. Res. (1998) [Pubmed]
  2. Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay "unique positive' NTP carcinogens. Matsuoka, A., Yamakage, K., Kusakabe, H., Wakuri, S., Asakura, M., Noguchi, T., Sugiyama, T., Shimada, H., Nakayama, S., Kasahara, Y., Takahashi, Y., Miura, K.F., Hatanaka, M., Ishidate, M., Morita, T., Watanabe, K., Hara, M., Odawara, K., Tanaka, N., Hayashi, M., Sofuni, T. Mutat. Res. (1996) [Pubmed]
  3. Mutagenicity studies with palm fruit carotene. Masuda, M., Haresaku, M., Takei, T., Nakamura, T. The Journal of toxicological sciences. (1995) [Pubmed]
  4. Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Demyanenko, G.P., Schachner, M., Anton, E., Schmid, R., Feng, G., Sanes, J., Maness, P.F. Neuron (2004) [Pubmed]
  5. Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. Naus, S., Richter, M., Wildeboer, D., Moss, M., Schachner, M., Bartsch, J.W. J. Biol. Chem. (2004) [Pubmed]
  6. A novel chordin-like protein inhibitor for bone morphogenetic proteins expressed preferentially in mesenchymal cell lineages. Nakayama, N., Han , C.E., Scully, S., Nishinakamura, R., He, C., Zeni, L., Yamane, H., Chang, D., Yu, D., Yokota, T., Wen, D. Dev. Biol. (2001) [Pubmed]
  7. Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells. Fernández-Martínez, A., Mollá, B., Mayoral, R., Boscá, L., Casado, M., Martín-Sanz, P. Biochem. J. (2006) [Pubmed]
  8. Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor-2. Rolf, B., Lang, D., Hillenbrand, R., Richter, M., Schachner, M., Bartsch, U. J. Neurosci. Res. (2003) [Pubmed]
  9. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Oren, A., Toporik, A., Biton, S., Almogy, N., Eshel, D., Bernstein, J., Savitsky, K., Rotman, G. Gene (2004) [Pubmed]
  10. Thermochemotherapy with cis-platinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan only. Honess, D.J., Bleehen, N.M. The British journal of radiology. (1985) [Pubmed]
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