Disease relevance of CHRDL1

• Causes of CHL include external canal atresia and neoplasms, myringosclerosis, middle ear anomalies, effusion, cholesteatomas, and neoplasms [1].
• Audiograms are used to determine if hearing loss is sensorineural (SNHL), conductive (CHL), or mixed (MHL) [1].
• API 50 CHL panels were useful for the identification of Lactobacillus species [2].
• Therefore, in order to evaluate the generality of clastogenicity of low pH conditions, chromosomal aberration tests were carried out on Chinese hamster cell line cells (CHO-K1, CHL, Don and V79 379A) and human cells (HeLa and peripheral lymphocytes used as whole-blood cultures) [3].
• An evaluation of 602 patient admissions, 1,134 intermittent access devices, and 2,268 observed indwelling device days demonstrated more pain at the insertion site for CHL than NL; however, no differences in objective signs of phlebitis were noted [4].

High impact information on CHRDL1

• The frequencies and the rates of segregation of the Emtr and Thgr (thioguanine-resistant, an X-linked recessive mutation) markers were determined from hybrids constructed between an Emtr-Thgr CHO cell line and various other Chinese hamster lines (V79, M3-1, CHO, GM7S, CHW and CHL) [5].
• Here we describe the intramolecular disulfide bonding, solution structure, and dynamics of a prototypical chordin-like CR repeat from procollagen IIA (CR(ColIIA)), which has been previously shown to bind TGF-beta1 and bone morphogenetic protein-2 [6].
• Solution structure and dynamics of a prototypical chordin-like cysteine-rich repeat (von Willebrand Factor type C module) from collagen IIA [6].
• Moreover, we show that Ventroptin precedes Noggin in the modulation of BMP activity in the developing cartilages [7].
• The observed changes in plasma total cholesterol were not significantly different than the values predicted by the Keys' equation, delta CHL = 1.35(2 delta S-delta P) + 1.5 delta Z [8].

Biological context of CHRDL1

• The three polymorphisms studied were in strong linkage disequilibrium in both the group of CHL patients and the unrelated individuals [9].
• Mean hPL was also lower in some pregnancies resulting in normal-weight neonates with abnormally low PI or short CHL, suggesting that these neonates, despite normal birth weight achievement, may represent previously unsuspected [10].
• STUDY DESIGN: Sham-controlled study of metabolic effects of CHL during sound stimulation [11].
• The REAL/WHO classification recognises a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (CHL), reflecting the differences in clinical presentation and behaviour, morphology, phenotype, and molecular features [12].
• Natural degreening was accompanied by a marked decrease in transcript levels of 1-deoxy-d-xylulose 5-phosphate synthase (DXS) and geranylgeranyl reductase (CHL P) while, conversely, pheophorbide a oxygenase (PaO) and phytoene synthase (PSY) gene expression increased [13].

Anatomical context of CHRDL1

• CHL indicates disease in the external auditory canal, tympanic membrane, or middle ear; CT with thin bone algorithms is the best study [1].
• The nonpermissive category for MVA consisted of three human cell lines HeLa, 293, and SW 839; one rhesus monkey cell line FRhK-4; two Chinese hamster cell lines CHO and CHL; one pig cell line PK(15); and three rabbit cell lines RK13, RAB-9, and SIRC [14].
• In vitro studies on bacterial, yeast and various mammalian cell lines including DON, CHO, CHL cells and primary hepatocytes demonstrate the absence of interactions with or damage to DNA [15].
• The borders between CHL and anaplastic large cell lymphoma have become sharper, whereas those between LP-HL and T cell rich B cell lymphoma remain ill defined [12].
• The aglycone, steviol, however, produced dose-related positive responses in some mutagenicity tests, i.e. the forward mutation assay using Salmonella typhimurium TM677, the chromosomal aberration test using Chinese hamster lung fibroblast cell line (CHL) and the gene mutation assay using CHL [16].

Associations of CHRDL1 with chemical compounds

• These data suggest that although probucol causes a decrease in HDL-CHL, it may act anti-atherogenically by modulating HDL metabolism and stimulating reverse transfer of CHL from peripheral tissue [17].
• We report treatment results with fludarabine and prednisone in 22 pretreated B-CLL patients in progressive disease, refractory to CHL and other regimens [18].
• Plant geranylgeranyl hydrogenase (CHL P) reduces free geranylgeranyl diphosphate to phytil diphosphate, which provides the side chain to chlorophylls, tocopherols, and plastoquinones [19].
• In fact, CHL levels in RDs were higher than those in humans and some avian species, while DDT levels in RDs were much lower than other animals [20].
• The relative contribution of OCs could be ranked as follows: Ringed seal females: sigmaPCB > sigma DDT > sigma CHL > sigma HCH > HCB > Mirex [21].

Analytical, diagnostic and therapeutic context of CHRDL1

• We have previously demonstrated by differential scanning calorimetry that approximately 1-2% of total CHL V79 cellular protein denatures during a 10- to 15-min exposure to 43 degrees C (J. E. Lepock et al., J. Cell. Physiol. 137, 14-24 (1988)) [22].
• METHODS: Maximum cycling power (Pmax) and optimal pedaling rate (Vopt, a surrogate measure for muscle fiber type) were determined for 195 boys and men, 8-70 years of age, by using inertial load cycle ergometry [23].
• In normal rats, single and repeated oral administration of the AI-extract, at a dose of 10mg/kg produced a small but significant decrease in plasma CHL levels (P<0.05) [24].
• METHODS: This study has identified and reports on 46 arthroscopically identified subscapularis tears, 25 "hidden" rotator interval lesions (SGHL/MCHL complex) and 6 SGHL/CHL complex plastic deformation lesions in 165 patients undergoing shoulder arthroscopy for conditions ranging from anterior instability to rotator cuff tears [25].
• Usefulness of calf circumference (CC) for screening low birth weight (LBW) was assessed in comparison with other anthropometric measurements, crown heel and crown rump lengths (CHL, CRL), Chest (Ch C), head (HC) and arm (AC) circumferences in 256 infants within 24 hours of birth [26].

References