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Gene Review

PPP1R9B  -  protein phosphatase 1, regulatory subunit 9B

Homo sapiens

Synonyms: Neurabin-2, Neurabin-II, PPP1R6, PPP1R9, Protein phosphatase 1 regulatory subunit 9B, ...
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Disease relevance of PPP1R9B


Psychiatry related information on PPP1R9B


High impact information on PPP1R9B


Biological context of PPP1R9B


Anatomical context of PPP1R9B


Associations of PPP1R9B with chemical compounds


Physical interactions of PPP1R9B


Regulatory relationships of PPP1R9B

  • Spinophilin regulates also seven-transmembrane receptor signalling and may provide a link between some of these receptors and intracellular mitogenic signalling events dependent on p70(S6) kinase and Rac G protein-GEF [16].

Other interactions of PPP1R9B


Analytical, diagnostic and therapeutic context of PPP1R9B

  • We describe a gastric non neoplastic ulceration that arose late after six years from an esophagectomy, with an end-side cervical esophagogastrostomy, for a spino-cellular carcinoma [20].


  1. Moderate instability of the trinucleotide repeat in spino bulbar muscular atrophy. Biancalana, V., Serville, F., Pommier, J., Julien, J., Hanauer, A., Mandel, J.L. Hum. Mol. Genet. (1992) [Pubmed]
  2. Isolation and characterization of trinucleotide repeat containing partial transcripts in human spinal cord. Kaushik, N., Malaspina, A., Schalling, M., Baas, F., de Belleroche, J. Neurogenetics (1998) [Pubmed]
  3. Comparison of two ELISA methods for measuring levels of the phosphorylated neurofilament heavy chain. Petzold, A., Shaw, G. J. Immunol. Methods (2007) [Pubmed]
  4. The importance of spino-pelvic balance in L5-s1 developmental spondylolisthesis: a review of pertinent radiologic measurements. Labelle, H., Roussouly, P., Berthonnaud, E., Dimnet, J., O'Brien, M. Spine. (2005) [Pubmed]
  5. The case of clinically benign spino-cerebral meningitis in the development of cranial basis neoplasm. Mitosek-Szewczyk, K., Iłzecka, J. Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina. (1994) [Pubmed]
  6. Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Law, A.J., Weickert, C.S., Hyde, T.M., Kleinman, J.E., Harrison, P.J. The American journal of psychiatry. (2004) [Pubmed]
  7. Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. Koh, P.O., Bergson, C., Undie, A.S., Goldman-Rakic, P.S., Lidow, M.S. Arch. Gen. Psychiatry (2003) [Pubmed]
  8. Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Liu, W., Yuen, E.Y., Allen, P.B., Feng, J., Greengard, P., Yan, Z. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein. Vivo, M., Calogero, R.A., Sansone, F., Calabrò, V., Parisi, T., Borrelli, L., Saviozzi, S., La Mantia, G. J. Biol. Chem. (2001) [Pubmed]
  10. Neurabin II mediates doublecortin-dephosphorylation on actin filaments. Tsukada, M., Prokscha, A., Eichele, G. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  11. Inhibition of hippocampal estrogen synthesis causes region-specific downregulation of synaptic protein expression in hippocampal neurons. Prange-Kiel, J., Fester, L., Zhou, L., Lauke, H., Carrétero, J., Rune, G.M. Hippocampus. (2006) [Pubmed]
  12. Evoked potentials from the lower urinary tract. II. The spino-cortical neuraxis. A methodological study. Gerstenberg, T.C., Nordling, J., Hald, T. Scandinavian journal of urology and nephrology. Supplementum. (1991) [Pubmed]
  13. The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines. Grossman, S.D., Hsieh-Wilson, L.C., Allen, P.B., Nairn, A.C., Greengard, P. Neuromolecular Med. (2002) [Pubmed]
  14. Clozapine and haloperidol differentially regulate dendritic spine formation and synaptogenesis in rat hippocampal neurons. Critchlow, H.M., Maycox, P.R., Skepper, J.N., Krylova, O. Mol. Cell. Neurosci. (2006) [Pubmed]
  15. Estrogenic Agonist Activity of ICI 182,780 (Faslodex) in Hippocampal Neurons: Implications for Basic Science Understanding of Estrogen Signaling and Development of Estrogen Modulators with a Dual Therapeutic Profile. Zhao, L., O'neill, K., Brinton, R.D. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  16. Spinophilin: from partners to functions. Sarrouilhe, D., di Tommaso, A., Métayé, T., Ladeveze, V. Biochimie (2006) [Pubmed]
  17. S100A8 and S100A9 calcium-binding proteins: localization within normal and cyclosporin A-induced overgrowth gingiva. Echelard, S., Hoyaux, D., Hermans, M., Daelemans, P., Roth, J., Philippart, P., Pochet, R. Connect. Tissue Res. (2002) [Pubmed]
  18. Direct and indirect effects of estrogen on rat hippocampus. Prange-Kiel, J., Rune, G.M. Neuroscience (2006) [Pubmed]
  19. The multiple tumor syndrome. Personal experience. Hanganu, E. Revista medico-chirurgicală a Societăţii de Medici şi Naturalişti din Iaşi. (2002) [Pubmed]
  20. A rare complication of surgical management for esophageal tumor: a non neoplastic belated fistula between stomach and main right bronchus. Brega Massone, P.P., Lequaglie, C., Ferro, F., Gallino, G., Magnani, B., Conti, B., Cataldo, I. The Journal of cardiovascular surgery. (2000) [Pubmed]
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