Gene Review:
NPY4R - neuropeptide Y receptor Y4
Homo sapiens
Synonyms:
NPY4-R, Neuropeptide Y receptor type 4, PP1, PPYR1, Pancreatic polypeptide receptor 1, ...
Gehlert,
Yang,
George,
Wang,
Schober,
Gackenheimer,
Johnson,
Beavers,
Gadski,
Baez,
Tsukada,
Prokscha,
Eichele,
Ballantyne,
Voisin,
Goumain,
Lorinet,
Maoret,
Laburthe,
Schillace,
Voltz,
Sim,
Shenolikar,
Scott,
Menke,
Philippi,
Vogelmann,
Seidel,
Lutz,
Adler,
Wedlich,
Cox,
Tough,
Gehlert,
Gehlert,
Schober,
Beavers,
Gadski,
Hoffman,
Smiley,
Chance,
Lundell,
Larhammar,
Wu,
Tkachuck,
Roberson,
Schubach,
Fetissov,
Kopp,
Hökfelt,
- The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity. Wu, D.Y., Tkachuck, D.C., Roberson, R.S., Schubach, W.H. J. Biol. Chem. (2002)
- Internalization of cloned pancreatic polypeptide receptors is accelerated by all types of Y4 agonists. Parker, M.S., Sah, R., Sheriff, S., Balasubramaniam, A., Parker, S.L. Regul. Pept. (2005)
- Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. Takakura, S., Kohno, T., Manda, R., Okamoto, A., Tanaka, T., Yokota, J. Int. J. Oncol. (2001)
- Vitamin E and the Y4 agonist BA-129 decrease prostate cancer growth and production of vascular endothelial growth factor. Yu, A., Somasundar, P., Balsubramaniam, A., Rose, A.T., Vona-Davis, L., McFadden, D.W. J. Surg. Res. (2002)
- Role of serine/threonine protein phosphatase in Alzheimer's disease. Tian, Q., Wang, J. Neurosignals (2002)
- Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans, H., Bollen, M. Physiol. Rev. (2004)
- Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Mumby, M.C., Walter, G. Physiol. Rev. (1993)
- RET Is Constitutively Activated by Novel Tandem Mutations that Alter the Active Site Resulting in Multiple Endocrine Neoplasia Type 2B. Cranston, A.N., Carniti, C., Oakhill, K., Radzio-Andzelm, E., Stone, E.A., McCallion, A.S., Hodgson, S., Clarke, S., Mondellini, P., Leyland, J., Pierotti, M.A., Whittaker, J., Taylor, S.S., Bongarzone, I., Ponder, B.A. Cancer Res. (2006)
- Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. Kishikawa, K., Chalfant, C.E., Perry, D.K., Bielawska, A., Hannun, Y.A. J. Biol. Chem. (1999)
- Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways. Citro, S., Ravasi, S., Rovati, G.E., Capra, V. Am. J. Respir. Cell Mol. Biol. (2005)
- Augmentation of retinoic acid-induced granulocytic differentiation in HL-60 leukemia cells by serine/threonine protein phosphatase inhibitors. Morita, K., Nishikawa, M., Kobayashi, K., Deguchi, K., Ito, M., Nakano, T., Shima, H., Nagao, M., Kuno, T., Tanaka, C. FEBS Lett. (1992)
- Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein. O'Donnell, R.W., Johnson, D.K., Ziegler, L.M., DiMattina, A.J., Stone, R.I., Holland, J.A. Endothelium (2003)
- Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. Lutz, C.M., Richards, J.E., Scott, K.L., Sinha, S., Yang-Feng, T.L., Frankel, W.N., Thompson, D.A. Genomics (1997)
- Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14. Darby, K., Eyre, H.J., Lapsys, N., Copeland, N.G., Gilbert, D.J., Couzens, M., Antonova, O., Sutherland, G.R., Jenkins, N.A., Herzog, H. Genomics (1997)
- The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. Lundell, I., Statnick, M.A., Johnson, D., Schober, D.A., Starbäck, P., Gehlert, D.R., Larhammar, D. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release. Small, C.J., Morgan, D.G., Meeran, K., Heath, M.M., Gunn, I., Edwards, C.M., Gardiner, J., Taylor, G.M., Hurley, J.D., Rossi, M., Goldstone, A.P., O'Shea, D., Smith, D.M., Ghatei, M.A., Bloom, S.R. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. Bard, J.A., Walker, M.W., Branchek, T.A., Weinshank, R.L. J. Biol. Chem. (1995)
- NPY regulates catecholamine secretion from human adrenal chromaffin cells. Cavadas, C., Silva, A.P., Mosimann, F., Cotrim, M.D., Ribeiro, C.A., Brunner, H.R., Grouzmann, E. J. Clin. Endocrinol. Metab. (2001)
- Pharmacological characterization of (125)I-1229U91 binding to Y1 and Y4 neuropeptide Y/Peptide YY receptors. Schober, D.A., Gackenheimer, S.L., Heiman, M.L., Gehlert, D.R. J. Pharmacol. Exp. Ther. (2000)
- Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. Cox, H.M., Tough, I.R. Br. J. Pharmacol. (2002)
- Studies of the human, rat, and guinea pig Y4 receptors using neuropeptide Y analogues and two distinct radioligands. Berglund, M.M., Lundell, I., Eriksson, H., Söll, R., Beck-Sickinger, A.G., Larhammar, D. Peptides (2001)
- Introduction to the reviews on neuropeptide Y. Gehlert, D.R. Neuropeptides (2004)
- Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. Terry-Lorenzo, R.T., Elliot, E., Weiser, D.C., Prickett, T.D., Brautigan, D.L., Shenolikar, S. J. Biol. Chem. (2002)
- Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells. Lee, H.J., Kim, E., Jee, B., Hahn, J.H., Han, K., Jung, K.C., Park, S.H., Lee, H. Exp. Mol. Med. (2002)
- Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor. Gehlert, D.R., Schober, D.A., Beavers, L., Gadski, R., Hoffman, J.A., Smiley, D.L., Chance, R.E., Lundell, I., Larhammar, D. Mol. Pharmacol. (1996)
- Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. Schillace, R.V., Voltz, J.W., Sim, A.T., Shenolikar, S., Scott, J.D. J. Biol. Chem. (2001)
- Neurabin II mediates doublecortin-dephosphorylation on actin filaments. Tsukada, M., Prokscha, A., Eichele, G. Biochem. Biophys. Res. Commun. (2006)
- Structure of a paralytic peptide from an insect, Manduca sexta. Yu, X.Q., Prakash, O., Kanost, M.R. J. Pept. Res. (1999)
- Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. Kassenbrock, C.K., Hunter, S., Garl, P., Johnson, G.L., Anderson, S.M. J. Biol. Chem. (2002)
- Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines. Menke, A., Philippi, C., Vogelmann, R., Seidel, B., Lutz, M.P., Adler, G., Wedlich, D. Cancer Res. (2001)
- Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation. Caruso, R., Pallone, F., Fina, D., Gioia, V., Peluso, I., Caprioli, F., Stolfi, C., Perfetti, A., Spagnoli, L.G., Palmieri, G., Macdonald, T.T., Monteleone, G. Am. J. Pathol. (2006)
- Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Wieland, H.A., Engel, W., Eberlein, W., Rudolf, K., Doods, H.N. Br. J. Pharmacol. (1998)
- Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. Lundell, I., Blomqvist, A.G., Berglund, M.M., Schober, D.A., Johnson, D., Statnick, M.A., Gadski, R.A., Gehlert, D.R., Larhammar, D. J. Biol. Chem. (1995)
- Cloning and characterization of Rhesus monkey neuropeptide Y receptor subtypes. Gehlert, D.R., Yang, P., George, C., Wang, Y., Schober, D., Gackenheimer, S., Johnson, D., Beavers, L.S., Gadski, R.A., Baez, M. Peptides (2001)
- Peptide YY(1-36) and Peptide YY(3-36): Part I. Distribution, release and actions. Ballantyne, G.H. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2006)
- Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture. Abounader, R., Elhusseiny, A., Cohen, Z., Olivier, A., Stanimirovic, D., Quirion, R., Hamel, E. J. Cereb. Blood Flow Metab. (1999)
- Functional and molecular properties of the human recombinant Y4 receptor: resistance to agonist-promoted desensitization. Voisin, T., Goumain, M., Lorinet, A.M., Maoret, J.J., Laburthe, M. J. Pharmacol. Exp. Ther. (2000)
- Distribution of NPY receptors in the hypothalamus. Fetissov, S.O., Kopp, J., Hökfelt, T. Neuropeptides (2004)
- Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue. Gliksman, N.R., Parsons, S.F., Salmon, E.D. J. Cell Biol. (1992)