The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

EED  -  embryonic ectoderm development

Homo sapiens

Synonyms: HEED, Polycomb protein EED, WAIT-1, WAIT1, WD protein associating with integrin cytoplasmic tails 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of EED


Psychiatry related information on EED

  • They were randomly assigned to four conditions: (1) one-session (E1); or (2) five-sessions of exposure (E5); (3) five-sessions of cognitive therapy (C5); and (4) Wait-list for 5 weeks [4].
  • Mental health. Wait not, want not [5]?
  • This study extends the compliance literature through: (1) an analysis of the effects of compliance training in long-term institutionalized mentally retarded adults, (2) the investigation of a third response class "Wait" requests, and (3) an assessment of stimulus generalization [6].
  • Seventy-eight motor vehicle accident survivors with chronic (greater than 6 months) PTSD, or severe sub-syndromal PTSD, completed a randomized controlled comparison of cognitive behavioral therapy (CBT), supportive psychotherapy (SUPPORT), or a Wait List control condition with two detailed assessments [7].

High impact information on EED

  • Finally, the histone deacetylase inhibitor trichostatin A (ref. 17) relieves transcriptional repression mediated by EED, but not by HPC2, a human homologue of polycomb [8].
  • SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex [1].
  • We further find that overexpression of SUV39H1 induces selective nuclear relocalization of HPC/HPH PcG proteins but not of the EED/EZH2 PcG proteins [9].
  • The present study interrogated the genetic, biochemical and molecular interaction of BMI1 and EED, pivotal constituents of heterologous Polycomb complexes, in the regulation of vertebral identity during mouse development [10].
  • Strikingly, methylated lysine 27 of histone H3 (H3-K27), a mediator of Polycomb complex recruitment to target genes, stably associated with the EED complex during the maintenance phase of Hox gene repression [10].

Chemical compound and disease context of EED

  • Human EED, a member of the superfamily of WD-40 repeat proteins and of the Polycomb group proteins, has been identified as a cellular partner of the human immunodeficiency virus type 1 (HIV-1) matrix (MA) protein (R. Peytavi et al., J. Biol. Chem. 274:1635-1645, 1999) [2].
  • The aim of our study was to evaluate the efficacy and toxicity of a bi-weekly chemohormonal regimen consisting of epirubicin, etoposide, and low-dose dexamethasone (EED) in patients with hormone-refractory prostate cancer (HRPC) [11].

Biological context of EED


Anatomical context of EED


Associations of EED with chemical compounds

  • In EED, two putative discrete IN-binding sites were mapped to its N-terminal moiety, at a distance from the MA-binding site, but EED-IN interaction also required the integrity of the EED last two WD repeats [2].
  • Please Wait until I Finish [18].

Physical interactions of EED

  • SUZ12 is a Polycomb group protein that forms Polycomb repressive complexes (PRC2/3) together with EED and histone methyltransferase EZH2 [19].

Other interactions of EED

  • Two distant topological sorting signals were required for efficient nuclear import of the 4.1R80 isoform: a basic peptide, KKKRER, encoded by alternative exon 16 and acting as a weak core nuclear localization signal (4.1R NLS), and an acidic peptide, EED, encoded by alternative exon 5 [20].

Analytical, diagnostic and therapeutic context of EED

  • In 19 patients who had cardiac catheterization druing the follow-up period, the discharge EED/PR-AC ratio correlated inversely with the angiographic ejection fraction (r = 0.79; p less than 0.001) [21].
  • The third patient, with the most severe arteriopathy, had to wait 1 year for a donor, and the attempted transplantation was complicated by ventricular tachycardia; death occurred 2 days after surgery [22].
  • As part of its Wait Time Strategy, the Ontario Ministry of Health and Long-Term Care provided significant amounts of money to perform more cases with the understanding that improving access by reducing wait times is not just a matter of increasing funding [23].
  • METHODS: Wait lists from 4 Canadian transplantation centers were examined for causes of living kidney donor exclusion [24].
  • METHODS: Of the 120 residents from a home for the aged, 69 were stratified based on age (five year intervals) and randomly allocated to three groups i.e., Yoga (physical postures, relaxation techniques, voluntarily regulated breathing and lectures on yoga philosophy), Ayurveda (a herbal preparation), and Wait-list control (no intervention) [25].


  1. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Cao, R., Zhang, Y. Mol. Cell (2004) [Pubmed]
  2. The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1. Violot, S., Hong, S.S., Rakotobe, D., Petit, C., Gay, B., Moreau, K., Billaud, G., Priet, S., Sire, J., Schwartz, O., Mouscadet, J.F., Boulanger, P. J. Virol. (2003) [Pubmed]
  3. Electroencephalographic findings in patients with mild Parkinson's disease treated with L-dopa and placebo. Paddison, R.M., Ferriss, G.S., Martinez, R.D. South. Med. J. (1976) [Pubmed]
  4. One vs five sessions of exposure and five sessions of cognitive therapy in the treatment of claustrophobia. Ost, L.G., Alm, T., Brandberg, M., Breitholtz, E. Behaviour research and therapy. (2001) [Pubmed]
  5. Mental health. Wait not, want not? Walker, S. The Health service journal. (1998) [Pubmed]
  6. The effects of "do", "don't" and "wait" requests training on compliance behavior and stimulus generalization. Montgomery, R.W., Ayllon, T. Journal of behavior therapy and experimental psychiatry. (1993) [Pubmed]
  7. A controlled evaluation of cognitive behavioural therapy for posttraumatic stress in motor vehicle accident survivors. Blanchard, E.B., Hickling, E.J., Devineni, T., Veazey, C.H., Galovski, T.E., Mundy, E., Malta, L.S., Buckley, T.C. Behaviour research and therapy. (2003) [Pubmed]
  8. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. van der Vlag, J., Otte, A.P. Nat. Genet. (1999) [Pubmed]
  9. Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Sewalt, R.G., Lachner, M., Vargas, M., Hamer, K.M., den Blaauwen, J.L., Hendrix, T., Melcher, M., Schweizer, D., Jenuwein, T., Otte, A.P. Mol. Cell. Biol. (2002) [Pubmed]
  10. Juxtaposed Polycomb complexes co-regulate vertebral identity. Kim, S.Y., Paylor, S.W., Magnuson, T., Schumacher, A. Development (2006) [Pubmed]
  11. Bi-weekly epirubicin, etoposide and low-dose dexamethasone for hormone-refractory prostate cancer. Odrazka, K., Vaculikova, M., Petera, J., Moravek, P., Prosvic, P., Zoul, Z., Rydel, L., Brodak, M., Veselsky, Z., Louda, M., Simakova, E. International journal of urology : official journal of the Japanese Urological Association. (2003) [Pubmed]
  12. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. Bracken, A.P., Pasini, D., Capra, M., Prosperini, E., Colli, E., Helin, K. EMBO J. (2003) [Pubmed]
  13. In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. Verschure, P.J., van der Kraan, I., de Leeuw, W., van der Vlag, J., Carpenter, A.E., Belmont, A.S., van Driel, R. Mol. Cell. Biol. (2005) [Pubmed]
  14. Substrate preferences of the EZH2 histone methyltransferase complex. Martin, C., Cao, R., Zhang, Y. J. Biol. Chem. (2006) [Pubmed]
  15. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. Rietzler, M., Bittner, M., Kolanus, W., Schuster, A., Holzmann, B. J. Biol. Chem. (1998) [Pubmed]
  16. SETting the stage. Eed-Enx1 leaves an epigenetic signature on the inactive X chromosome. Chadwick, B.P., Willard, H.F. Dev. Cell (2003) [Pubmed]
  17. Canadian Association of General Surgeons and American College of Surgeons evidence based reviews in surgery. 13. Wait-and-see policy or laparoscopic cholecystectomy after endoscopic sphincterotomy for bile-duct stones. Barkun, J., Dixon, E., Strasberg, S. Canadian journal of surgery. Journal canadien de chirurgie. (2005) [Pubmed]
  18. Please Wait until I Finish. Leonidas, J.C., Taylor, G. Radiology (2007) [Pubmed]
  19. Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. Furuno, K., Masatsugu, T., Sonoda, M., Sasazuki, T., Yamamoto, K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  20. Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R. Gascard, P., Nunomura, W., Lee, G., Walensky, L.D., Krauss, S.W., Takakuwa, Y., Chasis, J.A., Mohandas, N., Conboy, J.G. Mol. Biol. Cell (1999) [Pubmed]
  21. Echocardiography in unstable angina. Nixon, J.V., Hillert, M.C., Lipscomb, K.M., Smitherman, T.C. Cardiology (1981) [Pubmed]
  22. Early liver transplantation is crucial in children with liver disease and pulmonary artery hypertension. Losay, J., Piot, D., Bougaran, J., Ozier, Y., Devictor, D., Houssin, D., Bernard, O. J. Hepatol. (1998) [Pubmed]
  23. The pivotal role of critical care and surgical efficiencies in supporting Ontario's Wait Time Strategy: Part 3. Trypuc, J., Hudson, A., MacLeod, H. Healthcare quarterly (Toronto, Ont.) (2006) [Pubmed]
  24. The impact of accepting living kidney donors with mild hypertension or proteinuria on transplantation rates. Karpinski, M., Knoll, G., Cohn, A., Yang, R., Garg, A., Storsley, L. Am. J. Kidney Dis. (2006) [Pubmed]
  25. Influence of Yoga and Ayurveda on self-rated sleep in a geriatric population. Manjunath, N.K., Telles, S. Indian J. Med. Res. (2005) [Pubmed]
WikiGenes - Universities