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Gene Review

pfkA  -  6-phosphofructokinase

Escherichia coli O157:H7 str. Sakai

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Disease relevance of pfkA


High impact information on pfkA


Chemical compound and disease context of pfkA


Biological context of pfkA


Anatomical context of pfkA


Associations of pfkA with chemical compounds


Other interactions of pfkA


Analytical, diagnostic and therapeutic context of pfkA


  1. Nucleotide sequence of the phosphofructokinase gene from Bacillus stearothermophilus and comparison with the homologous Escherichia coli gene. French, B.A., Chang, S.H. Gene (1987) [Pubmed]
  2. Renaturation of the allosteric phosphofructokinase from Escherichia coli. Martel, A., Garel, J.R. J. Biol. Chem. (1984) [Pubmed]
  3. Cloning, sequencing, and expression of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii. Ladror, U.S., Gollapudi, L., Tripathi, R.L., Latshaw, S.P., Kemp, R.G. J. Biol. Chem. (1991) [Pubmed]
  4. Kinetic and structural characterization of phosphofructokinase from Lactobacillus bulgaricus. Paricharttanakul, N.M., Ye, S., Menefee, A.L., Javid-Majd, F., Sacchettini, J.C., Reinhart, G.D. Biochemistry (2005) [Pubmed]
  5. Sequencing, cloning, and high-level expression of the pfp gene, encoding a PP(i)-dependent phosphofructokinase from the extremely thermophilic eubacterium Dictyoglomus thermophilum. Ding, Y.H., Ronimus, R.S., Morgan, H.W. J. Bacteriol. (2000) [Pubmed]
  6. Active-site mutants altering the cooperativity of E. coli phosphofructokinase. Berger, S.A., Evans, P.R. Nature (1990) [Pubmed]
  7. Conversion of allosteric inhibition to activation in phosphofructokinase by protein engineering. Lau, F.T., Fersht, A.R. Nature (1987) [Pubmed]
  8. Mutations in the active site of Escherichia coli phosphofructokinase. Hellinga, H.W., Evans, P.R. Nature (1987) [Pubmed]
  9. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. Walker, J.E., Saraste, M., Runswick, M.J., Gay, N.J. EMBO J. (1982) [Pubmed]
  10. A route for fructose utilization by Escherichia coli involving the fucose regulon. Kornberg, H., Lourenco, C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  11. The cooperativity and allosteric inhibition of Escherichia coli phosphofructokinase depend on the interaction between threonine-125 and ATP. Auzat, I., Le Bras, G., Garel, J.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  12. Fructose 6-phosphate prevents the proteolyzed derivative of Escherichia coli phosphofructokinase from dissociation and inactivation. Le Bras, G., Garel, J.R. J. Biol. Chem. (1985) [Pubmed]
  13. Specific suppression of heterotropic interactions in phosphofructokinase by the mutation of leucine 178 into tryptophan. Serre, M.C., Teschner, W., Garel, J.R. J. Biol. Chem. (1990) [Pubmed]
  14. Temperature-induced inversion of allosteric phenomena. Braxton, B.L., Tlapak-Simmons, V.L., Reinhart, G.D. J. Biol. Chem. (1994) [Pubmed]
  15. Pre-steady state quantification of the allosteric influence of Escherichia coli phosphofructokinase. Pham, A.S., Reinhart, G.D. J. Biol. Chem. (2001) [Pubmed]
  16. Site-directed mutagenesis of rabbit muscle phosphofructokinase cDNA. Mutations at glutamine 200 affect the allosteric properties of the enzyme. Li, J., Zhu, X., Byrnes, M., Nelson, J.W., Chang, S.H. J. Biol. Chem. (1993) [Pubmed]
  17. ADP-dependent glucokinase/phosphofructokinase, a novel bifunctional enzyme from the hyperthermophilic archaeon Methanococcus jannaschii. Sakuraba, H., Yoshioka, I., Koga, S., Takahashi, M., Kitahama, Y., Satomura, T., Kawakami, R., Ohshima, T. J. Biol. Chem. (2002) [Pubmed]
  18. Generation of catalytically active 6-phosphofructokinase from Saccharomyces cerevisiae in a cell-free system. Edelmann, A., Kirchberger, J., Naumann, M., Kopperschläger, G. Eur. J. Biochem. (2000) [Pubmed]
  19. NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties. Brunner, N.A., Brinkmann, H., Siebers, B., Hensel, R. J. Biol. Chem. (1998) [Pubmed]
  20. Urea-induced inactivation, dissociation, and unfolding of the allosteric phosphofructokinase from Escherichia coli. Bras, G.L., Teschner, W., Deville-Bonne, D., Garel, J.R. Biochemistry (1989) [Pubmed]
  21. Dissection of the effector-binding site and complementation studies of Escherichia coli phosphofructokinase using site-directed mutagenesis. Lau, F.T., Fersht, A.R. Biochemistry (1989) [Pubmed]
  22. E. coli phosphofructokinase synthesized in vitro from a ColE1 hybrid plasmid. Thomson, J.A. Gene (1977) [Pubmed]
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