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LCMVsSgp2  -  nucleoprotein

Lymphocytic choriomeningitis virus

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Disease relevance of LCMVsSgp2


High impact information on LCMVsSgp2

  • Infection of chimeric mice with either Listeria monocytogenes or vaccinia virus expressing the nucleoprotein (NP) antigen from lymphocytic choriomeningitis virus (LCMV) primed H2-D(b)-restricted, but not H2-K(d)-restricted CTL responses, demonstrating the requirement for BM-derived APCs for successful priming of CTL responses to these pathogens [6].
  • LCMV infection of HY-transgenic C57BL/6 mice induced antiviral CTLs that lysed target cells coated with two of the three immunodominant epitopes previously defined for LCMV (glycoprotein 33 and nucleoprotein 397) [7].
  • Such mice express the viral nucleoprotein (NP) of lymphocytic choriomeningitis virus (LCMV) under control of the rat insulin promoter in their pancreatic beta cells and < 2% spontaneously develop diabetes [8].
  • The participation of IL-2 in insulin-dependent (type 1) diabetes (IDDM) was analyzed in transgenic (tg) mice expressing the nucleoprotein (NP) of lymphocytic choriomeningitis virus and IL-2 under control of the rat insulin promoter focally in beta cells of the islets of Langerhans [9].
  • Neither cytotoxic T lymphocytes (CTL) nor antibodies directed against the viral tg (NP) were generated [9].

Chemical compound and disease context of LCMVsSgp2


Biological context of LCMVsSgp2


Anatomical context of LCMVsSgp2


Associations of LCMVsSgp2 with chemical compounds

  • Two days after nucleoprotein biosynthesis was terminated in a tetracycline-regulated transfectant, the presentation of the NP118 epitope ceased [22].
  • Cytoplasmic viral nucleoprotein complexes were labeled with [3H]uridine in the presence or absence of actinomycin D, purified partially by sedimentation in D2O-sucrose gradients, and adsorbed to fixed Staphylococus aureus cells in the presence of anti-LCMV immunoglobulin G [23].
  • Lysosomotropic weak bases (chloroquine and ammonium chloride) and carboxylic ionophores (monensin and nigericin) inhibited virus entry, assessed as virus nucleoprotein expression at early times post-infection, indicating that the entry process involved a pH-dependent fusion step in intracellular vesicles [24].

Analytical, diagnostic and therapeutic context of LCMVsSgp2


  1. Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation. Sigal, L.J., Rock, K.L. J. Exp. Med. (2000) [Pubmed]
  2. Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide. Aichele, P., Hengartner, H., Zinkernagel, R.M., Schulz, M. J. Exp. Med. (1990) [Pubmed]
  3. A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria. Ochsenbein, A.F., Karrer, U., Klenerman, P., Althage, A., Ciurea, A., Shen, H., Miller, J.F., Whitton, J.L., Hengartner, H., Zinkernagel, R.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus. Saron, M.F., Fayolle, C., Sebo, P., Ladant, D., Ullmann, A., Leclerc, C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions. Molina, T.J., Bachmann, M.F., Kündig, T.M., Zinkernagel, R.M., Mak, T.W. J. Immunol. (1993) [Pubmed]
  6. Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens. Lenz, L.L., Butz, E.A., Bevan, M.J. J. Exp. Med. (2000) [Pubmed]
  7. Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response. Zarozinski, C.C., Welsh, R.M. J. Exp. Med. (1997) [Pubmed]
  8. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice. von Herrath, M.G., Dyrberg, T., Oldstone, M.B. J. Clin. Invest. (1996) [Pubmed]
  9. Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response. von Herrath, M.G., Allison, J., Miller, J.F., Oldstone, M.B. J. Clin. Invest. (1995) [Pubmed]
  10. Detection of Lassa virus antinucleoprotein immunoglobulin G (IgG) and IgM antibodies by a simple recombinant immunoblot assay for field use. Ter Meulen, J., Koulemou, K., Wittekindt, T., Windisch, K., Strigl, S., Conde, S., Schmitz, H. J. Clin. Microbiol. (1998) [Pubmed]
  11. DNA-based immunisation against rabies and rabies-related viruses: towards multivalent vaccines. Perrin, P., Jacob, Y., Desmézières, E., Tordo, N. Developments in biologicals. (2000) [Pubmed]
  12. Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes. von Herrath, M.G., Efrat, S., Oldstone, M.B., Horwitz, M.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  13. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein. Zarozinski, C.C., Fynan, E.F., Selin, L.K., Robinson, H.L., Welsh, R.M. J. Immunol. (1995) [Pubmed]
  14. Cross-presentation of the long-lived lymphocytic choriomeningitis virus nucleoprotein does not require neosynthesis and is enhanced via heat shock proteins. Basta, S., Stoessel, R., Basler, M., van den Broek, M., Groettrup, M. J. Immunol. (2005) [Pubmed]
  15. DNA vaccination against persistent viral infection. Martins, L.P., Lau, L.L., Asano, M.S., Ahmed, R. J. Virol. (1995) [Pubmed]
  16. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. Bachmann, M.F., Schorle, H., Kühn, R., Müller, W., Hengartner, H., Zinkernagel, R.M., Horak, I. J. Virol. (1995) [Pubmed]
  17. Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. Christen, U., Darwiche, R., Thomas, H.E., Wolfe, T., Rodrigo, E., Chervonsky, A., Flavell, R.A., von Herrath, M.G. Diabetes (2004) [Pubmed]
  18. Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Oxenius, A., Bachmann, M.F., Zinkernagel, R.M., Hengartner, H. Eur. J. Immunol. (1998) [Pubmed]
  19. Lysis of infected cells in vivo by antiviral cytolytic T cells demonstrated by release of cell internal viral proteins. Kyburz, D., Speiser, D.E., Battegay, M., Hengartner, H., Zinkernagel, R.M. Eur. J. Immunol. (1993) [Pubmed]
  20. Attenuated Listeria monocytogenes as a live vector for induction of CD8+ T cells in vivo: a study with the nucleoprotein of the lymphocytic choriomeningitis virus. Goossens, P.L., Milon, G., Cossart, P., Saron, M.F. Int. Immunol. (1995) [Pubmed]
  21. Lymphocytic choriomeningitis virus. X. Demonstration of nucleoprotein on the surface of infected cells. Zeller, W., Bruns, M., Lehmann-Grube, F. Virology (1988) [Pubmed]
  22. Cutting edge: neosynthesis is required for the presentation of a T cell epitope from a long-lived viral protein. Khan, S., de Giuli, R., Schmidtke, G., Bruns, M., Buchmeier, M., van den Broek, M., Groettrup, M. J. Immunol. (2001) [Pubmed]
  23. Viral proteins and RNAs in BHK cells persistently infected by lymphocytic choriomeningitis virus. van der Zeijst, B.A., Bleumink, N., Crawford, L.V., Swyryd, E.A., Stark, G.R. J. Virol. (1983) [Pubmed]
  24. Mechanism of lymphocytic choriomeningitis virus entry into cells. Borrow, P., Oldstone, M.B. Virology (1994) [Pubmed]
  25. Peptide-induced antiviral protection by cytotoxic T cells. Schulz, M., Zinkernagel, R.M., Hengartner, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  26. Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes. Slifka, M.K., Shen, H., Matloubian, M., Jensen, E.R., Miller, J.F., Ahmed, R. J. Virol. (1996) [Pubmed]
  27. DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. Rodriguez, F., Zhang, J., Whitton, J.L. J. Virol. (1997) [Pubmed]
  28. Neonatal DNA immunization with a plasmid encoding an internal viral protein is effective in the presence of maternal antibodies and protects against subsequent viral challenge. Hassett, D.E., Zhang, J., Whitton, J.L. J. Virol. (1997) [Pubmed]
  29. Antibodies to Lassa virus Z protein and nucleoprotein co-occur in human sera from Lassa fever endemic regions. Günther, S., Kühle, O., Rehder, D., Odaibo, G.N., Olaleye, D.O., Emmerich, P., ter Meulen, J., Schmitz, H. Med. Microbiol. Immunol. (Berl.) (2001) [Pubmed]
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