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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Dipetalonema


High impact information on Dipetalonema


Chemical compound and disease context of Dipetalonema


Biological context of Dipetalonema


Anatomical context of Dipetalonema


Associations of Dipetalonema with chemical compounds

  • Serologic and immediate skin tests with Dirofilaria immitis antigen were positive, and blood smears transiently showed microfilariae of Acanthocheilonema perstans after the patient had been treated with diethylcarbamazine [12].
  • Similar embryostatic and macrofilaricidal effects of MDC were observed in Acanthocheilonema viteae adult worms [13].
  • A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo[1,2-a]pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds [14].
  • We describe a 17-kDa antigen (Av17) of the rodent filarial parasite Acanthocheilonema viteae, which shows amino acid homologies to cystatin C, a major cysteine protease inhibitor belonging to family 2 of the cystatin superfamily [15].
  • Restimulation of splenocytes from mf-infected animals with an extract of Acanthocheilonema viteae, a related filarial worm which lacks endosymbiotic bacteria, also resulted in NO production and proliferative suppression, demonstrating that lipopolysaccharide of bacterial origin is not essential to the induction of iNOS activity [16].

Gene context of Dipetalonema


Analytical, diagnostic and therapeutic context of Dipetalonema


  1. Chitinase genes expressed by infective larvae of the filarial nematodes, Acanthocheilonema viteae and Onchocerca volvulus. Wu, Y., Adam, R., Williams, S.A., Bianco, A.E. Mol. Biochem. Parasitol. (1996) [Pubmed]
  2. Immunogenicity of the extracellular copper/zinc superoxide dismutase of the filarial parasite Acanthocheilonema viteae delivered by a two-phase vaccine strain of Salmonella typhimurium. Lattemann, C.T., Yan, Z.X., Matzen, A., Meyer, T.F., Apfel, H. Parasite Immunol. (1999) [Pubmed]
  3. The successful treatment of Dipetalonema perstans filariasis with mebendazole. Wahlgren, M. Ann. Trop. Med. Parasitol. (1982) [Pubmed]
  4. Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility. Hoerauf, A., Nissen-Pähle, K., Schmetz, C., Henkle-Dührsen, K., Blaxter, M.L., Büttner, D.W., Gallin, M.Y., Al-Qaoud, K.M., Lucius, R., Fleischer, B. J. Clin. Invest. (1999) [Pubmed]
  5. Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. Goodridge, H.S., Wilson, E.H., Harnett, W., Campbell, C.C., Harnett, M.M., Liew, F.Y. J. Immunol. (2001) [Pubmed]
  6. A phosphorylcholine-containing filarial nematode-secreted product disrupts B lymphocyte activation by targeting key proliferative signaling pathways. Deehan, M.R., Frame, M.J., Parkhouse, R.M., Seatter, S.D., Reid, S.D., Harnett, M.M., Harnett, W. J. Immunol. (1998) [Pubmed]
  7. Studies on the site and mechanism of attachment of phosphorylcholine to a filarial nematode secreted glycoprotein. Houston, K.M., Cushley, W., Harnett, W. J. Biol. Chem. (1997) [Pubmed]
  8. Monoclonal antibodies to parasite antigens found in the serum of Dirofilaria immitis-infected dogs. Weil, G.J., Malane, M.S., Powers, K.G., Blair, L.S. J. Immunol. (1985) [Pubmed]
  9. Effect of mebendazole and levamisole on Onchocerca volvulus and Dipetalonema perstans. Maertens, K., Wéry, M. Trans. R. Soc. Trop. Med. Hyg. (1975) [Pubmed]
  10. Acanthocheilonema viteae (Dipetalonema viteae) in mice: attempts to correct the low responder phenotype of the BALB/c host. Storey, N., Behnke, J.M., Wakelin, D. Int. J. Parasitol. (1989) [Pubmed]
  11. Soleus muscle adenosine-5'-triphosphate (ATP) levels in Mastomys natalensis with Dipetalonema viteae infections: effect of diethylcarbamazine. Mukherjee, M., Reddy, A.B. Trop. Med. Parasitol. (1985) [Pubmed]
  12. Studies of immediate hypersensitivity in a patient with Acanthocheilonema perstans filarial infection. Rubin, R.H., Austen, K.F., Goetzl, E.J. J. Infect. Dis. (1975) [Pubmed]
  13. Brugia malayi and Acanthocheilonema viteae: antifilarial activity of transglutaminase inhibitors in vitro. Rao, U.R., Mehta, K., Subrahmanyam, D., Vickery, A.C. Antimicrob. Agents Chemother. (1991) [Pubmed]
  14. Bis-cationic heteroaromatics as macrofilaricides: synthesis of bis-amidine and bis-guanylhydrazone derivatives of substituted imidazo[1,2-a]pyridines. Sundberg, R.J., Biswas, S., Kumar Murthi, K., Rowe, D., McCall, J.W., Dzimianski, M.T. J. Med. Chem. (1998) [Pubmed]
  15. A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production. Hartmann, S., Kyewski, B., Sonnenburg, B., Lucius, R. Eur. J. Immunol. (1997) [Pubmed]
  16. NO contributes to proliferative suppression in a murine model of filariasis. O'Connor, R.A., Jenson, J.S., Devaney, E. Infect. Immun. (2000) [Pubmed]
  17. Antioxidant enzymes in Acanthocheilonema viteae and effect of antifilarial agents. Batra, S., Chatterjee, R.K., Srivastava, V.M. Biochem. Pharmacol. (1990) [Pubmed]
  18. Molecular cloning and demonstration of an aminopeptidase activity in a filarial nematode glycoprotein. Harnett, W., Houston, K.M., Tate, R., Garate, T., Apfel, H., Adam, R., Haslam, S.M., Panico, M., Paxton, T., Dell, A., Morris, H., Brzeski, H. Mol. Biochem. Parasitol. (1999) [Pubmed]
  19. Acanthocheilonema viteae: stage-specific expression of G-protein alpha-subunits. Grant, K.R., Harnett, M.M., Harnett, W. Exp. Parasitol. (1997) [Pubmed]
  20. A nuclear magnetic resonance study of the role of phosphoenol pyruvate carboxykinase (PEPCK) in the glucose metabolism of Dipetalonema viteae. Christie, D.A., Powell, J.W., Stables, J.N., Watt, R.A. Mol. Biochem. Parasitol. (1987) [Pubmed]
  21. Development of Dipetalonema gracile and D. caudispina to the infective stage in Culicoides hollensis. Eberhard, M.L., Lowrie, R.C., Orihel, T.C. J. Parasitol. (1979) [Pubmed]
  22. Electron microscopic studies on microfilariae of Dipetalonema viteae and Litomosoides carinii: the occurrence of intracellular parasites after treatment with metrifonate or diethylcarbamazine. Mehlhorn, H., Steinhorst, U., Lindenblatt, B., Grüntzig, J., Thomas, H. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectiousdiseases, para... (1981) [Pubmed]
  23. Stage-specific antibody response of Mastomys natalensis during the course of Dipetalonema viteae infection. Singh, D.P., Misra, S., Chatterjee, R.K. Folia Parasitol. (1988) [Pubmed]
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