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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Filarioidea


High impact information on Filarioidea

  • Cloning and expression analysis of two mucin-like genes encoding microfilarial sheath surface proteins of the parasitic nematodes Brugia and Litomosoides [5].
  • Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis [6].
  • 3-Aminopyrrolidines bearing acyl substituents on either nitrogen and N-acylated 1,4-diazabicyclo[3.2.1]octanes are potent microfilaricides in the Litomosoides carinii gerbil test system but have no effect on adult worms [7].
  • A large proportion of the nucleotide substitutions between species were synonymous. vrrA has 35% identity with the microfilarial sheath protein shp2 of the parasitic worm Litomosoides carinii [8].
  • In addition, sequence comparison of E1 to its homologue from Litomosoides sigmodontis and to Caenorhabditis elegans ankyrin defines two further putative functional domains [9].

Biological context of Filarioidea


Anatomical context of Filarioidea


Associations of Filarioidea with chemical compounds


Gene context of Filarioidea


Analytical, diagnostic and therapeutic context of Filarioidea


  1. Expansion of NK cells with reduction of their inhibitory Ly-49A, Ly-49C, and Ly-49G2 receptor-expressing subsets in a murine helminth infection: contribution to parasite control. Korten, S., Volkmann, L., Saeftel, M., Fischer, K., Taniguchi, M., Fleischer, B., Hoerauf, A. J. Immunol. (2002) [Pubmed]
  2. Antibiotic therapy in murine filariasis (Litomosoides sigmodontis): comparative effects of doxycycline and rifampicin on Wolbachia and filarial viability. Volkmann, L., Fischer, K., Taylor, M., Hoerauf, A. Trop. Med. Int. Health (2003) [Pubmed]
  3. Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 8. The action of furazolidone on adult worms and microfilariae. Wegerhof, P.H., Lämmler, G., Sänger, I., Zahner, H. Tropenmedizin und Parasitologie. (1979) [Pubmed]
  4. Embryogenesis in Litomosoides carinii from pyridoxine deficient cotton rats. Beg, M.A., Storey, D.M. J. Helminthol. (1993) [Pubmed]
  5. Cloning and expression analysis of two mucin-like genes encoding microfilarial sheath surface proteins of the parasitic nematodes Brugia and Litomosoides. Hirzmann, J., Hintz, M., Kasper, M., Shresta, T.R., Taubert, A., Conraths, F.J., Geyer, R., Stirm, S., Zahner, H., Hobom, G. J. Biol. Chem. (2002) [Pubmed]
  6. Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis. Volkmann, L., Saeftel, M., Bain, O., Fischer, K., Fleischer, B., Hoerauf, A. Infect. Immun. (2001) [Pubmed]
  7. Antifilarial agents. 3-Aminopyrrolidine and 1,4-diazabicyclo[3.2.1]octane derivatives as analogues of diethylcarbamazine. Sturm, P., Cory, M., Henry, D.W. J. Med. Chem. (1977) [Pubmed]
  8. Identification of a region of genetic variability among Bacillus anthracis strains and related species. Andersen, G.L., Simchock, J.M., Wilson, K.H. J. Bacteriol. (1996) [Pubmed]
  9. The putatively protective Onchocerca volvulus neuronal protein E1 is a member of the death domain protein family. Erttmann, K.D., Domeyer, A., Gallin, M. FEBS Lett. (1996) [Pubmed]
  10. Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis. Pfarr, K.M., Fischer, K., Hoerauf, A. Med. Microbiol. Immunol. (Berl.) (2003) [Pubmed]
  11. Cytochemical demonstration of lectin binding-sites in the cuticle and tissues of Acanthocheilonema viteae (Filarioidea). Kiefer, E., Rudin, W., Hecker, H. Acta Trop. (1989) [Pubmed]
  12. Effect of stimulation and blockade of mononuclear phagocyte system on the treatment of microfilaremia of Litomosoides carinii in the cotton rat and the jird. Hayashi, Y., Nogami, S., Shibuya, T. Jpn. J. Exp. Med. (1984) [Pubmed]
  13. Trans-splicing of an early embryo mRNA in Litomosoides carinii, coding for the major microfilarial sheath protein gp22. Christ, H., Hirzmann, J., Conraths, F., Zahner, H., Stirm, S., Hobom, G. Gene (1992) [Pubmed]
  14. Dimethylaminoethanol is a major component of the Litomosoides carinii microfilarial sheath. Hintz, M., Kasper, M., Stahl, B., Geyer, R., Kalinowski, H.O., Karas, M., Kühnhardt, S., Schott, H.H., Conraths, F., Zahner, H., Stirm, S. Mol. Biochem. Parasitol. (1996) [Pubmed]
  15. Effect of arsenical drugs on glutathione metabolism of Litomosoides carinii. Bhargava, K.K., Le Trang, N., Cerami, A., Eaton, J.W. Mol. Biochem. Parasitol. (1983) [Pubmed]
  16. Litomosoides carinii microfilarial sheaths: partial amino acid sequences of several major polypeptide constituents. Hintz, M., Hirzmann, J., Hobom, G., Linder, D., Lottspeich, F., Schott, H.H., Conraths, F.J., Zahner, H., Stirm, S. Mol. Biochem. Parasitol. (1994) [Pubmed]
  17. Effect of thiamine deficiency on the filarial infection of albino rats with Litomosoides carinii. Prasad, R., Rao, Y.V., Mehta, K., Subrahmanyam, D. Int. J. Parasitol. (1980) [Pubmed]
  18. Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages. Volkmann, L., Bain, O., Saeftel, M., Specht, S., Fischer, K., Brombacher, F., Matthaei, K.I., Hoerauf, A. Med. Microbiol. Immunol. (Berl.) (2003) [Pubmed]
  19. 2,2'-Dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone--a new antifilarial agent. Fatma, N., Sharma, S., Chatterjee, R.K. Acta Trop. (1989) [Pubmed]
  20. Immune response to the filaria Litomosoides sigmodontis in susceptible and resistant mice. Maréchal, P., Le Goff, L., Hoffman, W., Rapp, J., Oswald, I.P., Ombrouck, C., Taylor, D.W., Bain, O., Petit, G. Parasite Immunol. (1997) [Pubmed]
  21. Purification and properties of phosphoenolpyruvate carboxylase from Molinema dessetae (Nematoda: Filarioidea). Loiseau, P.M., Gayral, P., Petek, F. Parasitology (1993) [Pubmed]
  22. Litomosoides carinii: mode of action in vitro of benzothiazole and amoscanate derivatives with antifilarial activity. Davies, K.P., Zahner, H., Köhler, P. Exp. Parasitol. (1989) [Pubmed]
  23. Demonstration of anti-cuticular antibodies by immuno-electron microscopy in sera of mice immunized with cuticular extracts and isolated cuticles of adult Dipetalonema viteae (Filarioidea). Kiefer, E., Rudin, W., Betschart, B., Weiss, N., Hecker, H. Acta Trop. (1986) [Pubmed]
  24. Occurrence of microfilariae in various hollow organs and in the peritoneal cavity after treatment of Litomosoides carinii infected Mastomys natalensis with diethylcarbamazine and haloxon. Zahner, H., Weidner, E. Zeitschrift für Parasitenkunde (Berlin, Germany) (1983) [Pubmed]
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