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MeSH Review

Felty's Syndrome

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Disease relevance of Felty's Syndrome


High impact information on Felty's Syndrome


Chemical compound and disease context of Felty's Syndrome


Biological context of Felty's Syndrome


Anatomical context of Felty's Syndrome


Gene context of Felty's Syndrome

  • Complement C4B-null alleles in Felty's syndrome [25].
  • The Caucasian patients had relatively severe disease and comprised 75 patients with RA vasculitis, 22 with Felty's syndrome and 89 who had undergone a joint replacement (hip or knee) within 15 years of the onset of disease [26].
  • Whereas susceptibility to RA is strongly associated with a conserved HLA-DR beta epitope associated with several DRB1 alleles, it is primarily the Dw4 allele which is associated with progression to Felty's syndrome [27].
  • The role of interleukin-8 and other cytokines in the pathogenesis of Felty's syndrome [28].
  • TAP2 transporter gene polymorphisms have been ascertained in patients with rheumatoid arthritis (RA) and Felty's syndrome (FS) to determine whether particular alleles of this gene are disease associated [29].

Analytical, diagnostic and therapeutic context of Felty's Syndrome


  1. The Felty syndrome and G-CSF-associated thrombocytopenia and severe anemia. Wun, T. Ann. Intern. Med. (1993) [Pubmed]
  2. Reversal of neutropenia with methotrexate treatment in patients with Felty's syndrome. Correlation of response with neutrophil-reactive IgG. Fiechtner, J.J., Miller, D.R., Starkebaum, G. Arthritis Rheum. (1989) [Pubmed]
  3. Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis. van Gaalen, F.A., Toes, R.E., Ditzel, H.J., Schaller, M., Breedveld, F.C., Verweij, C.L., Huizinga, T.W. Arthritis Rheum. (2004) [Pubmed]
  4. Efficacy of lithium in rheumatoid arthritis with granulocytopenia (felty's syndrome). A preliminary report. Gupta, R.C., Robinson, W.A., Smyth, C.J. Arthritis Rheum. (1975) [Pubmed]
  5. Felty's syndrome: long-term followup after treatment with auranofin. Bellelli, A., Veneziani, M., Tumiati, B. Arthritis Rheum. (1987) [Pubmed]
  6. Cyclosporine in Felty's syndrome. Coiffier, B. N. Engl. J. Med. (1986) [Pubmed]
  7. Improvement of rheumatoid arthritis following splenectomy for Felty syndrome. Khan, M.A., Kushner, I. JAMA (1977) [Pubmed]
  8. Decreased spleen size and increased neutrophils in patients with Felty syndrome. Effects of gold sodium thiomalate therapy. Hurd, E.R., Cheatum, D.E. JAMA (1976) [Pubmed]
  9. Activation of human complement by immunoglobulin G antigranulocyte antibody. Rustagi, P.K., Currie, M.S., Logue, G.L. J. Clin. Invest. (1982) [Pubmed]
  10. Letter: Lithium in Felty's syndrome. Kaplan, R.A. Ann. Intern. Med. (1976) [Pubmed]
  11. Treatment of Felty's syndrome with low-dose oral methotrexate. Allen, L.S., Groff, G. Arthritis Rheum. (1986) [Pubmed]
  12. Treatment of Felty's syndrome with auranofin and methylprednisolone. Job-Deslandre, C., Menkès, C.J. Arthritis Rheum. (1989) [Pubmed]
  13. Rheumatoid arthritis: relationship with HLA-D. Stastny, P. Am. J. Med. (1983) [Pubmed]
  14. Kaposi's sarcoma in rheumatoid arthritis. Schottstaedt, M.W., Hurd, E.R., Stone, M.J. Am. J. Med. (1987) [Pubmed]
  15. Molecular characterisation of C4 null alleles found in Felty's syndrome. Hillarby, M.C., Strachan, T., Grennan, D.M. Ann. Rheum. Dis. (1990) [Pubmed]
  16. Phagocytosis and intracellular killing by polymorphonuclear cells from patients with rheumatoid arthritis and Felty's syndrome. Breedveld, F.C., van den Barselaar, M.T., Leigh, P.C., Cats, A., van Furth, R. Arthritis Rheum. (1985) [Pubmed]
  17. DQw7 and the C4B null allele in rheumatoid arthritis and Felty's syndrome. Clarkson, R., Bate, A.S., Grennan, D.M., Chattopadhyay, C., Sanders, P., Davis, M., Kelly, C. Ann. Rheum. Dis. (1990) [Pubmed]
  18. Polymorphonuclear cell function in rheumatoid arthritis and in Felty's syndrome. Howe, G.B., Fordham, J.N., Brown, K.A., Currey, H.L. Ann. Rheum. Dis. (1981) [Pubmed]
  19. Lack of association between DQ A and DX A polymorphisms with rheumatoid arthritis and Felty's syndrome. Bate, A.S., Ollier, W., Grennan, D.M. Dis. Markers (1990) [Pubmed]
  20. Rheumatoid arthritis associated with expanded populations of granular lymphocytes. Barton, J.C., Prasthofer, E.F., Egan, M.L., Heck, L.W., Koopman, W.J., Grossi, C.E. Ann. Intern. Med. (1986) [Pubmed]
  21. Increased endothelial cell adherence, aggregation, and superoxide generation by neutrophils incubated in systemic lupus erythematosus and Felty's syndrome sera. Hashimoto, Y., Ziff, M., Hurd, E.R. Arthritis Rheum. (1982) [Pubmed]
  22. Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis. Starkebaum, G., Loughran, T.P., Gaur, L.K., Davis, P., Nepom, B.S. Arthritis Rheum. (1997) [Pubmed]
  23. Analysis of the platelet-type thrombin receptor in 20 cases of large granular lymphocyte proliferations. Macey, M.G., Howells, G.L., Stone, S.R., Newland, A.C. Leukemia (1996) [Pubmed]
  24. Effect of corticosteroid treatment on hemopoiesis in vivo and in vitro in a patient with Felty's syndrome. Moccia, F., Mazzarello, G.P., Morra, L. Biomed. Pharmacother. (1991) [Pubmed]
  25. Complement C4B-null alleles in Felty's syndrome. Thomson, W., Sanders, P.A., Davis, M., Davidson, J., Dyer, P.A., Grennan, D.M. Arthritis Rheum. (1988) [Pubmed]
  26. Rheumatoid arthritis susceptibility and interleukin 10: a study of two ethnically diverse populations. MacKay, K., Milicic, A., Lee, D., Tikly, M., Laval, S., Shatford, J., Wordsworth, P. Rheumatology (Oxford, England) (2003) [Pubmed]
  27. Strong primary selection for the Dw4 subtype of DR4 accounts for the HLA-DQw7 association with Felty's syndrome. Lanchbury, J.S., Jaeger, E.E., Sansom, D.M., Hall, M.A., Wordsworth, P., Stedeford, J., Bell, J.I., Panayi, G.S. Hum. Immunol. (1991) [Pubmed]
  28. The role of interleukin-8 and other cytokines in the pathogenesis of Felty's syndrome. Meliconi, R., Uguccioni, M., Chieco-Bianchi, F., Pitzalis, C., Bowman, S., Facchini, A., Gasbarrini, G., Panayi, G.S., Kingsley, G.H. Clinical and experimental rheumatology. (1995) [Pubmed]
  29. TAP2D is associated with HLA-B44 and DR4 and may contribute to rheumatoid arthritis and Felty's syndrome susceptibility. Hillarby, M.C., Davies, E.J., Donn, R.P., Grennan, D.M., Ollier, W.E. Clinical and experimental rheumatology. (1996) [Pubmed]
  30. Cytotoxic chemotherapy for cancer in Felty's syndrome: role of lithium carbonate. Pazdur, R., Rossof, A.H. Blood (1981) [Pubmed]
  31. Lack of evidence for the presence of neutrophil autoantibodies in the serum of patients with Felty's syndrome. Goldschmeding, R., Breedveld, F.C., Engelfriet, C.P., von dem Borne, A.E. Br. J. Haematol. (1988) [Pubmed]
  32. IgE anti-IgG antibodies in patients with juvenile and adult rheumatoid arthritis including Felty's syndrome. Permin, H., Egeskjold, E.M. Allergy (1982) [Pubmed]
  33. Characterization of immune complexes and immunoglobulin G antibodies reactive with neutrophils in the sera of patients with Felty's syndrome. Starkebaum, G., Arend, W.P., Nardella, F.A., Gavin, S.E. J. Lab. Clin. Med. (1980) [Pubmed]
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