Disease relevance of Ossification, Heterotopic

• This possibility is further supported by the identification of a patient with atypical but severe platelike osteoma cutis (POC) and a mutation in GNAS1, indicating that inactivating mutations in GNAS1 may lead to severe progressive heterotopic ossification of skeletal muscle and deep connective tissue independently of AHO characteristics [1].
• Immunohistochemical methods were used to investigate the distribution pattern of the small proteoglycans decorin and proteoglycan-100 during different stages of heterotopic ossification of pressure sores of paraplegic patients [2].
• Parathyroid hormone-related protein in gastric cancers with heterotopic ossification [3].
• Reported here is a rare case of periarticular heterotopic ossification in the shoulder of a 38-year-old woman following head injury and 13 months in a coma [4].
• A patient, one year after flexor digitorum superficialis/profundus repair in the left index finger, was diagnosed with heterotopic ossification involving the palmar surface of the proximal phalanx creating a secondary proximal interphalangeal joint contracture [5].

High impact information on Ossification, Heterotopic

• Ossification of the posterior longitudinal ligament (OPLL) of the spine is a subset of "bone-forming" diseases, characterized by ectopic ossification in the spinal ligaments [6].
• Fibrodysplasia ossificans progressiva, a heritable disorder of severe heterotopic ossification, maps to human chromosome 4q27-31 [7].
• The high expression of BMPRs and ActRs in the ectopic ossified ligament suggests that BMPs and activin may be tightly involved in the pathological ossification process of OPLL [8].
• The inhibitor designed to suppress heterotopic ossification showed BMP antagonist activity in embryos and animal caps of X. laevis [9].
• In conclusion, overexpression of BMP-2 gene induced massive heterotopic ossification in skeletal muscles under graft-induced ischemic degeneration, which possibly up-regulates osteoprogenitor cells in situ [10].

Chemical compound and disease context of Ossification, Heterotopic

• The treatment of tenotomised animals with either disodium ethane-1, 1-diphosphonate (EHDP) or disodium dichloromethylene diphosphonate (Cl2MDP) has no effect on the process of heterotopic ossification which can be detected at the radiological or light microscopical level [11].
• Both AH 6809 and Rp-cAMP were found to prevent the later development of radiographically documented heterotopic ossification in 15 out of 16 animals, thus identifying prostaglandins as being required for the development of ectopic bone [12].
• BACKGROUND: There is controversy surrounding the relative effectiveness of local irradiation and oral indomethacin for prophylaxis against heterotopic ossification following surgical treatment of acetabular fractures [13].
• Disodium etidronate is the first therapeutic agent which may delay and partially prevent postoperative recurrence of heterotopic ossification [14].
• Effect of ibuprofen on heterotopic ossification after hip replacement [15].

Biological context of Ossification, Heterotopic

• Histocompatibility antigens in patients with ectopic ossification due to fibrodysplasia ossificans progressiva [16].
• Doses of 2.5 mg hOP-1 per g of matrix induced extensive osteogenesis initially with heterotopic ossification and displacement of the temporalis muscle above the defects [17].
• Radiation-induced suppression of the Bmp2 signal transduction pathway in the pluripotent mesenchymal cell line C2C12: an in vitro model for prevention of heterotopic ossification by radiotherapy [18].
• To treat the heterotopic ossification, indomethacin, etidronate, and graded range of motion were used [19].
• Cells isolated from trabecular bone samples and heterotopic ossification sites from six patients were evaluated for osteocalcin production after exposure to 1,25-dihydroxycholecalciferol, alkaline phosphatase activity, typing and synthesis of collagen, cell proliferation, and total protein content [20].

Anatomical context of Ossification, Heterotopic

• Ossification of the posterior longitudinal ligament (OPLL) is a pathological ossification in the spinal ligament, with formation of ectopic bone mainly through endochondral ossification [8].
• Decorin was detectable in the perivascular matrix of granulation tissue as well as in the stroma of heterotopic ossification [2].
• Diphosphonate treatment for heterotopic ossification in spinal cord injury patients [21].
• Limitation of flexor tendon excursion by heterotopic ossification after isolated flexor tendon laceration [5].
• These new findings represent the earliest documented changes that have ever been noted in fibrodysplasia ossificans progressiva, and provide further histopathologic support for the recent discovery that lymphocytes may play a role in the pathogenesis of heterotopic ossification in fibrodysplasia ossificans progressiva [22].

Gene context of Ossification, Heterotopic

• In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification [23].
• Our results suggest that Ahsg may be useful for prevention of the heterotopic ossification and the regulation of osteoinductive effects of BMP used with grafts [24].
• We used immunohistochemical techniques to investigate the distribution pattern of osteonectin, osteocalcin, bone sialoprotein II and the small proteoglycans decorin and PG 100 during different stages of heterotopic ossification (HO) in pressure sores of paraplegic patients [25].
• Fibrodysplasia ossificans progressiva (FOP) is a very rare disease characterized by congenital malformation of the great toes and progressive heterotopic ossification of muscles [26].
• Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification [27].

Analytical, diagnostic and therapeutic context of Ossification, Heterotopic

• Relation between ectopic ossification after total hip arthroplasty and activity of general inflammation in patients with ankylosing spondylitis [28].
• Prophylaxis with indomethacin for heterotopic ossification after Chiari osteotomy of the pelvis [29].
• Naproxen in the prevention of heterotopic ossification after total hip replacement [30].
• Three months after the operation, heterotopic ossification had developed in 12 (52%) patients in the control group and in 3 (11%) patients in the naproxen-treated group [31].
• The use of the three-phase bone scan in the early diagnosis of heterotopic ossification (HO) and in the evaluation of Didronel therapy [32].

References