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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Local Area Networks

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Disease relevance of Local Area Networks


High impact information on Local Area Networks

  • Exposure to either LAN or EMF can decrease production of melatonin by the pineal gland [6].
  • Both incongruent conditions elicited a large N400 followed by a left anterior negativity (LAN) time-locked to the moment of word category violation and a P600 effect [7].
  • The suppressive effects of a short-term LAN treatment on GH and insulin-like growth factor I (IGF-I) hypersecretion were shown to be similar to those obtained with sc octreotide [8].
  • A local area network of protonated water molecules [9].
  • Statistically significant synergy was found for the combination of ITZ and AMD and the combination of LAN and NIF, although with different intensities against ITZ-R strains [10].

Biological context of Local Area Networks


Anatomical context of Local Area Networks

  • Lansoprazole 30 mg b.d. appeared to be slightly more effective than LAN 15 mg b.d. in suppressing increased gastric acid secretion due to post-operative stress and in haemostasis in patients with upper gastrointestinal bleeding [14].
  • EMF and LAN are said to reduce circulating levels of the hormone melatonin which, in turn, allows estrogen levels to rise and stimulate the turnover of breast epithelial stem cells and increase the risk for malignant transformation [15].
  • The antiproliferative effect produced by a 48 h exposure to 5-FU or MIT was synergistically enhanced in all cell lines by a subsequent 48 h exposure to LAN [12].

Associations of Local Area Networks with chemical compounds

  • To avoid the inconvenience of multiple daily injections during long-term therapy, a slow release formulation of lanreotide (LAN), to be administered im at a dose of 30 mg every 7-14 days, has been introduced in the therapeutic management [8].
  • Addition of lanthanum (LAN), a molecule known to inhibit Ca2+ efflux via Ca(2+)-ATPase, curtailed Spd uptake by these cells [16].
  • Three laboratory-based studies, in which a total of 53 healthy young women were exposed at night to EMF or to LAN under controlled exposure conditions, were performed to determine whether such exposures reduce melatonin and are associated with further alterations in estrogen [15].
  • H2RA (cimetidine (CIM) 1.6 g or ranitidine (RAN) 300 mg) (eight studies) at 4 weeks, 67% vs. 37%: at 8 weeks, 81% vs. 49%: on lansoprazole (LAN) 30 mg vs. H2RA (three studies), 83% vs. 47% and 91% vs. 63% at 4 and 8 weeks, respectively [17].
  • METHODS: Patients were randomized to receive either 1 week of triple therapy with LAN 30 mg BID, clarithromycin 500 mg BID, and tinidazole 500 mg BID, followed by 3 weeks of LAN 30 mg BID, or 2 weeks of dual therapy with RBC 400 mg BID plus clarithromycin 500 mg BID, followed by 2 weeks of RBC 400 mg BID [18].

Gene context of Local Area Networks

  • The most commonly applied SST analogues are octreotide (OCT) and lanreotide (LAN), which are both available in a slow release formulation [19].
  • In this study, the cytochrome P450 (CYP) induction potential of pantoprazole (PAN) was evaluated and compared to two other proton pump inhibitors (PPIs), omeprazole (OM) and lansoprazole (LAN) [20].
  • Together our data suggest that changes in these proteins and their modification may predispose striatal projection neurons to dysfunction and then degeneratation in HD and provide a mechanism for LAN resistance in the disease [11].
  • Combined morphosyntactic and semantic violations elicited a P600 component and a negative ERP component within the latency range of the LAN and N400 components [21].
  • In the high contrast condition the LAN preceded the P200 component whereas in the low contrast condition it was present after this component [22].

Analytical, diagnostic and therapeutic context of Local Area Networks


  1. Lanreotide 60 mg, a new long-acting formulation: effectiveness in the chronic treatment of acromegaly. Attanasio, R., Baldelli, R., Pivonello, R., Grottoli, S., Bocca, L., Gasco, V., Giusti, M., Tamburrano, G., Colao, A., Cozzi, R. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  2. Comparative somatostatin receptor scintigraphy using in-111-DOTA-lanreotide and in-111-DOTA-Tyr3-octreotide versus F-18-FDG-PET for evaluation of somatostatin receptor-mediated radionuclide therapy. Virgolini, I., Patri, P., Novotny, C., Traub, T., Leimer, M., Füger, B., Li, S.R., Angelberger, P., Raderer, M., Wogritsch, S., Kurtaran, A., Kletter, K., Dudczak, R. Ann. Oncol. (2001) [Pubmed]
  3. Suppressive action of lansoprazole on gastric acidity and its clinical effect in patients with gastric ulcers: comparison with famotidine. Sakaguchi, M., Ashida, K., Umegaki, E., Miyoshi, H., Katsu, K. J. Clin. Gastroenterol. (1995) [Pubmed]
  4. Comparison of the effect of lansoprazole and omeprazole on intragastric acidity and gastroesophageal reflux in patients with gastroesophageal reflux disease. Janczewska, I., Sagar, M., Sjöstedt, S., Hammarlund, B., Iwarzon, M., Seensalu, R. Scand. J. Gastroenterol. (1998) [Pubmed]
  5. Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue. Pauley, S.M. Med. Hypotheses (2004) [Pubmed]
  6. Electric power, pineal function, and the risk of breast cancer. Stevens, R.G., Davis, S., Thomas, D.B., Anderson, L.E., Wilson, B.W. FASEB J. (1992) [Pubmed]
  7. The influence of semantic and syntactic context constraints on lexical selection and integration in spoken-word comprehension as revealed by ERPs. van den Brink, D., Hagoort, P. Journal of cognitive neuroscience. (2004) [Pubmed]
  8. Two-year follow-up of acromegalic patients treated with slow release lanreotide (30 mg). Baldelli, R., Colao, A., Razzore, P., Jaffrain-Rea, M.L., Marzullo, P., Ciccarelli, E., Ferretti, E., Ferone, D., Gaia, D., Camanni, F., Lombardi, G., Tamburrano, G. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  9. A local area network of protonated water molecules. Heberle, J. Biophys. J. (2004) [Pubmed]
  10. Potent synergistic in vitro interaction between nonantimicrobial membrane-active compounds and itraconazole against clinical isolates of Aspergillus fumigatus resistant to itraconazole. Afeltra, J., Vitale, R.G., Mouton, J.W., Verweij, P.E. Antimicrob. Agents Chemother. (2004) [Pubmed]
  11. Neuronal vulnerability in mouse models of Huntington's disease: membrane channel protein changes. Ariano, M.A., Wagle, N., Grissell, A.E. J. Neurosci. Res. (2005) [Pubmed]
  12. Lanreotide-induced modulation of 5-fluorouracil or mitomycin C cytotoxicity in human colon cancer cell lines: a preclinical study. Tesei, A., Ricotti, L., De Paola, F., Casini-Raggi, C., Barzanti, F., Frassineti, G.L., Zoli, W. Journal of chemotherapy (Florence, Italy) (2000) [Pubmed]
  13. Expression of p65 gene in experimental colon cancer under the influence of 5-fluorouracil given alone and in combination with hormonal modulation. Melen-Mucha, G., Balcerczak, E., Mucha, S., Panczyk, M., Lipa, S., Mirowski, M. Neoplasma (2004) [Pubmed]
  14. Intravenous administration of lansoprazole: a preliminary study of dose ranging and efficacy in upper gastrointestinal bleeding. Aoki, T. Aliment. Pharmacol. Ther. (1995) [Pubmed]
  15. Examination of the melatonin hypothesis in women exposed at night to EMF or bright light. Graham, C., Cook, M.R., Gerkovich, M.M., Sastre, A. Environ. Health Perspect. (2001) [Pubmed]
  16. Polyamine transport regulation by calcium and calmodulin: role of Ca(2+)-ATPase. Khan, N.A., Sezan, A., Quemener, V., Moulinoux, J.P. J. Cell. Physiol. (1993) [Pubmed]
  17. The role of proton pump inhibitors in the treatment of gastro-oesophageal reflux disease. Bardhan, K.D. Aliment. Pharmacol. Ther. (1995) [Pubmed]
  18. Lansoprazole-based triple therapy versus ranitidine bismuth citrate-based dual therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer: a multicenter, randomized, double-dummy study. Luzza, F., Giglio, A., Ciliberto, E., Belmonte, A., Cavaliere, C., Saccà, N., Frandina, C., Fiocca, R., Trimboli, V., Pallone, F. Clinical therapeutics. (2001) [Pubmed]
  19. Different response to the long-acting somatostatin analogues lanreotide and octreotide in a patient with a malignant carcinoid. Raderer, M., Kurtaran, A., Scheithauer, W., Fiebiger, W., Weinlaender, G., Oberhuber, G. Oncology (2001) [Pubmed]
  20. An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes. Masubuchi, N., Li, A.P., Okazaki, O. Chem. Biol. Interact. (1998) [Pubmed]
  21. Event-related potentials suggest early interaction between syntax and semantics during on-line sentence comprehension. Palolahti, M., Leino, S., Jokela, M., Kopra, K., Paavilainen, P. Neurosci. Lett. (2005) [Pubmed]
  22. Brain responses during sentence reading: visual input affects central processes. Gunter, T.C., Friederici, A.D., Hahne, A. Neuroreport (1999) [Pubmed]
  23. Serological grouping of streptococci: a collective evaluation in six laboratories of three rapid methods. Guinet, R., André, J., Barbé, G., Boude, M., Carret, G., Freydiére, A.M., Gille, Y., Marcel, J.P., Mazoyer, M.A. Med. Microbiol. Immunol. (Berl.) (1982) [Pubmed]
  24. RADPLANET--a functional radiology digital image network. Neilsen, I.R., Slater, J.M., Fischer, B. Journal of medical systems. (1987) [Pubmed]
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