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Chemical Compound Review

Xylene Red B     sodium 4-(3-diethylamino-6...

Synonyms: CHEBI:52101, Acid Red XB, Food Red 106, CAS-3520-42-1, AC1L1X8Z, ...
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Disease relevance of [6-diethylamino-9-(2,4-disulfophenyl)-2,7-dimethyl-xanthen-3-ylidene]-diethyl-azanium


High impact information on [6-diethylamino-9-(2,4-disulfophenyl)-2,7-dimethyl-xanthen-3-ylidene]-diethyl-azanium

  • METHODS: The antitumor activity of 17AAG and other Hsp90 inhibitors was determined by use of a sulforhodamine B-based cell growth inhibition assay in culture and by the arrest of xenograft tumor growth in nude mice [5].
  • A colorimetric assay based on sulforhodamine B was adopted to replace the more cumbersome clonogenic cell survival assay [6].
  • The SRB binds to the basic amino acids of cellular macromolecules; the solubilized stain is measured spectrophotometrically to determine relative cell growth or viability in treated and untreated cells [7].
  • However, because of certain technical advantages to use of the protein-binding dye sulforhodamine B (SRB) in a large-scale screening application, a detailed comparison of data generated by each type of assay was undertaken [8].
  • When fluorescence images of the two actins were compared using filter sets selective for either fluorescein isothiocyanate or lissamine rhodamine B sulfonyl chloride, essentially identical patterns of distribution were detected in both muscle and nonmuscle cells [9].

Chemical compound and disease context of [6-diethylamino-9-(2,4-disulfophenyl)-2,7-dimethyl-xanthen-3-ylidene]-diethyl-azanium


Biological context of [6-diethylamino-9-(2,4-disulfophenyl)-2,7-dimethyl-xanthen-3-ylidene]-diethyl-azanium


Anatomical context of [6-diethylamino-9-(2,4-disulfophenyl)-2,7-dimethyl-xanthen-3-ylidene]-diethyl-azanium


Associations of [6-diethylamino-9-(2,4-disulfophenyl)-2,7-dimethyl-xanthen-3-ylidene]-diethyl-azanium with other chemical compounds


Gene context of [6-diethylamino-9-(2,4-disulfophenyl)-2,7-dimethyl-xanthen-3-ylidene]-diethyl-azanium

  • METHODS AND MATERIALS: Cytotoxicity of hyperthermia and/or etoposide was evaluated using sulforhodamine-B in HeLa cells overexpressing MRP1 and their drug-sensitive counterparts [28].
  • Results from the sulforhodamine B cell survival assay and flow cytometry analysis show no significant difference among cells transfected with vector, p33ING1, and antisense p33ING1 [29].
  • Based on sulforhodamine B assays for the number of viable cells, the NQO1 clones showed increased sensitivity to EO9, an indoloquinone that undergoes bioactive reduction by NQO1 [30].
  • In this study, we investigated the estrogenic activity of environmental estrogens by a competition binding assay using a human recombinant estrogens receptor (hERbeta) and by a proliferation assay using MCF-7 cells and a sulforhodamine-B assay [31].
  • Lym-1-gelonin was very active in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium salt and sulforhodamine B in vitro cytotoxicity assays against the Raji lymphoma cell line and confirmed the fact that monoclonal antibody Lym-1 internalizes into human lymphoma cells [32].

Analytical, diagnostic and therapeutic context of [6-diethylamino-9-(2,4-disulfophenyl)-2,7-dimethyl-xanthen-3-ylidene]-diethyl-azanium


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  21. Acute effects of bradykinin on cerebral microvascular permeability in the anaesthetized rat. Sarker, M.H., Hu, D.E., Fraser, P.A. J. Physiol. (Lond.) (2000) [Pubmed]
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