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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hypogravity


High impact information on Hypogravity

  • Since the gravitational acceleration on Mars is about one-third that on Earth, and since particle settling speeds scale with gravity, we propose that some (although perhaps not all) Martian geomorphological features attributed to liquid flows may in fact be associated with dry granular flows in the presence of reduced gravity [5].
  • Exposure to both hyper- and hypogravity environments likely induces neurovegetative and/or stress effects that could account for Fos labeling in autonomic nuclei and in nervous structures involved in the hypothalamo-pituitary-adrenal axis [6].
  • The necessary manipulations required to use the device were tested on the KC-135 aircraft during the reduced gravity segment of parabolic flight [7].
  • Crystallization experiments with MB-1 have been carried out on the ground and in reduced gravity on board Columbia orbiter during mission STS-80 [8].
  • Changes in the cytoskeletal structures of vimentin and tubulin observed in cells exposed to low gravity conditions may have influenced the correct signal transduction [9].

Biological context of Hypogravity

  • We found no variations in the levels of metalloproteases and an increased synthesis of their inhibitors (TIMP), suggesting that hypogravity does not induce a pro-angiogenic phenotype [10].

Anatomical context of Hypogravity

  • Significant variations in time in the effective plasma ET-1 levels in the superior and inferior cava vessel blood of animals maintained for 6 days in hypogravity with respect to controls were observed [11].
  • Obtained results suggest that the effects of hypogravity on cultured human endothelial cells are, possibly, associated with protein kinase C and/or adenylate cyclase activity and are accompanied by noticeable functional cell changes [12].

Associations of Hypogravity with chemical compounds

  • In the decade preceding Apollo missions to the Moon, extensive studies were conducted on human locomotion in reduced gravity [13].
  • Space Station Freedom will provide the essential scientific and technological research in areas that require long exposures to reduced gravity conditions [14].
  • Useful modifications of earlier methods included splitting of the platelet rich plasma into multiple aliquots to improve pelleting efficiency at low gravity forces, use of saved platelet poor plasma to flush out injection syringes, and prompt use of commercial Indium-111-oxine sources 3 to 5 minutes after mixing with Ringer's Citrate Dextrose [15].
  • We report here the STARDUST experience, a recent collaborative effort that brings together a successful American program of microgravity experiments on particle formation aboard NASA KC-135 Reduced Gravity Research Aircraft and several Italian research groups with expertise in microgravity research and astrophysical dust formation [16].
  • Undecalcified (n = 140) and decalcified (n = 11) bone fragments were treated with either collagenase (to remove collagen portion; undecalcified n = 64, decalcified n = 11) or EDTA (to remove mineral portion; n = 76) under the reduced gravity environment on US Space Shuttle mission STS-57 [17].

Gene context of Hypogravity


Analytical, diagnostic and therapeutic context of Hypogravity


  1. Gravity effects on cellulose assembly. Brown, R.M., Kudlicka, K., Cousins, S.K., Nagy, R. Am. J. Bot. (1992) [Pubmed]
  2. Augmentation of the push-pull effect by terminal aortic occlusion during head-down tilt. Hakeman, A.L., Shepard, J.L., Sheriff, D.D. J. Appl. Physiol. (2003) [Pubmed]
  3. Intraspecific differences in bacterial responses to modelled reduced gravity. Baker, P.W., Leff, L.G. J. Appl. Microbiol. (2005) [Pubmed]
  4. Oxygen cost during exercise in simulated subgravity environments. Fox, E.L., Bartels, R.L., Chaloupka, E.C., Klinzing, J.E., Hoche, J. Aviation, space, and environmental medicine. (1975) [Pubmed]
  5. Dry granular flows can generate surface features resembling those seen in Martian gullies. Shinbrot, T., Duong, N.H., Kwan, L., Alvarez, M.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Fos expression in the rat brain after exposure to gravito-inertial force changes. Gustave Dit Duflo, S., Gestreau, C., Lacour, M. Brain Res. (2000) [Pubmed]
  7. Development of a whole blood staining device for use during space shuttle flights. Sams, C.F., Crucian, B.E., Clift, V.L., Meinelt, E.M. Cytometry. (1999) [Pubmed]
  8. Crystallization and stabilization of MB-1, a de novo designed protein for optimized feeding technology. Grundy, J., Morrison, J.J., MacCallum, J.D., Wirtanen, L., Beauregard, M. J. Biotechnol. (1998) [Pubmed]
  9. Signal transduction in T cells: an overview. Cogoli-Greuter, M., Lovis, P., Vadrucci, S. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (2004) [Pubmed]
  10. Modulation of human endothelial cell behaviour in simulated microgravity. Carlsson, S.I., Bertilaccio, M.T., Ascari, I., Bradamante, S., Maier, J.A. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (2002) [Pubmed]
  11. Effect of antiorthostatic hypokinetic/hypodynamia on urinary endothelin-1 and N-acetyl-beta-D-glucosaminidase excretion in rats. Capodicasa, E., Tassi, C., Rossi, R., Mezzasoma, L., Valiani, M., Biondi, R. Clin. Chim. Acta (1997) [Pubmed]
  12. The role of cytoskeleton in cell changes under condition of simulated microgravity. Buravkova, L.B., Romanov, Y.A. Acta astronautica. (2001) [Pubmed]
  13. Simulating reduced gravity: a review of biomechanical issues pertaining to human locomotion. Davis, B.L., Cavanagh, P.R. Aviation, space, and environmental medicine. (1993) [Pubmed]
  14. Life sciences issues affecting space exploration. White, R.J., Leonard, J.I., Leveton, L., Gaiser, K., Teeter, R. Microgravity science and technology. (1990) [Pubmed]
  15. Technical considerations in the study of indium-111-oxine labelled platelet survival patterns in dogs. Sharefkin, J., Rich, N.M. Lab. Anim. Sci. (1982) [Pubmed]
  16. An overview of the cosmic dust analogue material production in reduced gravity: the STARDUST experience. Ferguson, F., Lilleleht, L.U., Nuth, J., Stephens, J.R., Bussoletti, E., Colangeli, L., Mennella, V., Dell'Aversana, P., Mirra, C. Microgravity quarterly : MGQ. (1993) [Pubmed]
  17. Effect of microgravity on collagenase deproteinization and EDTA decalcification of bone fragments. Simske, S.J., Luttges, M.W. Microgravity science and technology. (1994) [Pubmed]
  18. Expression of cell adhesion molecules and lymphocyte-endothelium interaction under simulated hypogravity in vitro. Romanov, Y.A., Buravkova, L.B., Rikova, M.P., Antropova, E.N., Savchenko, N.N., Kabaeva, N.V. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (2001) [Pubmed]
  19. Effect of hypogravity on human lymphocyte activation. Cogoli, A., Valluchi-Morf, M., Mueller, M., Briegleb, W. Aviation, space, and environmental medicine. (1980) [Pubmed]
  20. Long-term effects of microgravity and possible countermeasures. Wolfe, J.W., Rummel, J.D. Advances in space research : the official journal of the Committee on Space Research (COSPAR). (1992) [Pubmed]
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