Disease relevance of Diffusion Magnetic Resonance Imaging

• BACKGROUND AND PURPOSE: We have previously shown that treatment with glutamate receptor antagonists after focal ischemia can partially reverse acute lesions measured with diffusion-weighted MRI [1].
• METHODS: Sixteen patients with acute stroke were examined consecutively with diffusion-weighted MRI and 99mTc-ethyl cysteinate dimer (99mTc-ECD) SPECT within 24 h of the onset of symptoms [2].
• The presence or absence of lactate may indicate the severity of the brain insult, and the combination of MRS, MRI, and diffusion-weighted MRI may assist in localizing and predicting a long-term brain injury [3].
• MR spectroscopic imaging and diffusion-weighted MRI for early detection of kainate-induced status epilepticus in the rat [4].
• PURPOSE: To study the characteristics of diffusion magnetic resonance imaging (MRI) contrast in a rat brain BT4C glioma during progression of ganciclovir (GCV)-thymidine kinase gene therapy-induced programmed cell death (PCD) in vivo [5].

Psychiatry related information on Diffusion Magnetic Resonance Imaging

• CONCLUSION: For the clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease, cortical hyperintensity signals on diffusion-weighted MRI are useful for the cortical form and thalamic hypoperfusion or hypometabolism on cerebral blood flow SPECT or [18F]2-fluoro-2-deoxy-d-glucose PET for the thalamic form [6].

High impact information on Diffusion Magnetic Resonance Imaging

• The real-time tetramethylammonium (TMA) method and diffusion-weighted MRI were used to measure the ECS volume fraction (alpha = ECS volume/total tissue volume) and the apparent diffusion coefficients (ADCs) of TMA (ADC(TMA)), diffusing exclusively in the ECS and of water (ADC(W)) [7].
• These results demonstrate the increased efficacy of the CD-UPRT GDEPT compared to CD alone both biochemically and in a preclinical model and validate both 19F MRS and diffusion-weighted MRI as tools to assess gene function and therapeutic efficacy [8].
• Therapeutic efficacy of DTI-015 using diffusion magnetic resonance imaging as an early surrogate marker [9].
• Serial magnetic resonance imaging (MRI) showed that IFN-beta treatment reduced lesion volume on diffusion-weighted MRI by 70% (P < 0.01) at 1 day after stroke [10].
• Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome [11].

Anatomical context of Diffusion Magnetic Resonance Imaging

• PURPOSE: Previous studies using diffusion MRI in patients with temporal lobe epilepsy have shown abnormal water diffusion in the hippocampus [12].
• NMDA, injected in the striatum of rats at postnatal days (P) 4, 7, 10, 14 and 21, induced a significant age-dependent reduction in the apparent diffusion coefficient (ADC) of tissue water in the striatum and the cerebral cortex monitored 1 h later using diffusion-weighted MRI [13].

Associations of Diffusion Magnetic Resonance Imaging with chemical compounds

• Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI [14].
• In a patient with the interval form of carbon monoxide (CO) poisoning diffusion weighted MRI and proton magnetic resonance spectroscopy (1H-MRS) were serially performed immediately after the appearance of delayed sequelae (the 23rd day after exposure) [15].
• Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: effect of lubeluzole [16].
• Prior and concurrent L-NAME administration blocked the changes on diffusion MRI and attenuated the morphologic changes, suggesting that NO and consequent peroxynitrite formation during ischemia-reperfusion contributes to cerebral injury [17].
• Diffusion-weighted MRI used to detect in vivo modulation of cortical spreading depression: comparison of sumatriptan and tonabersat [18].

Gene context of Diffusion Magnetic Resonance Imaging

• Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in rats [19].
• Brainstem diffusion-weighted MRI in boys with L1CAM mutations [20].
• The correlation in SCA1 between clinical severity and quantitative volumetric, diffusion MRI and proton MR spectroscopy findings in the brainstem indicates that these measurements might be employed for longitudinal studies and hopefully as surrogate markers in future pharmacological trials of this condition [21].
• CONCLUSIONS: Midline splenium changes are commonly seen on MRI diffusion-weighted imaging sequences [22].
• OBJECTIVE: To report a case of hGH-related iCJD with abnormal cerebellar MRI findings on fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted MRI (DWI) [23].

Analytical, diagnostic and therapeutic context of Diffusion Magnetic Resonance Imaging

• Transient encephalopathy after intrathekal methotrexate chemotherapy: diffusion-weighted MRI [24].
• Positron emission tomographic imaging and MRI, including diffusion-weighted MRI, were performed during and shortly after treatment with recombinant tissue plasminogen activator and 34 to 35 hours later [25].

References