Chemical Compound Review:
Prosynap (2S)-1-[4-(benzothiazol-2-yl- methyl-amino)...
Synonyms:
Lubeluzole, Prosynap (TN), CHEMBL281724, SureCN159725, JK-8792, ...
- Protection with lubeluzole against delayed ischemic brain damage in rats. A quantitative histopathologic study. Haseldonckx, M., Van Reempts, J., Van de Ven, M., Wouters, L., Borgers, M. Stroke (1997)
- Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide. Maiese, K., TenBroeke, M., Kue, I. J. Neurochem. (1997)
- Lubeluzole following traumatic brain injury in the rat. Kroppenstedt, S.N., Stroop, R., Kern, M., Thomale, U.W., Schneider, G.H., Unterberg, A.W. J. Neurotrauma (1999)
- Site of action of lubeluzole on voltage-sensitive Ca(2+) channels in isolated dorsal root ganglion cells of the rat: influence of pH. Marrannes, R., De Prins, E. J. Pharmacol. Exp. Ther. (2000)
- Critical temporal modulation of neuronal programmed cell injury. Maiese, K., Vincent, A.M. Cell. Mol. Neurobiol. (2000)
- Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group. Diener, H.C., Hacke, W., Hennerici, M., Rådberg, J., Hantson, L., De Keyser, J. Stroke (1996)
- Combined neuroprotection and reperfusion therapy for stroke. Effect of lubeluzole and diaspirin cross-linked hemoglobin in experimental focal ischemia. Aronowski, J., Strong, R., Grotta, J.C. Stroke (1996)
- Role of nitric oxide after brain ischaemia. Moro, M.A., Cárdenas, A., Hurtado, O., Leza, J.C., Lizasoain, I. Cell Calcium (2004)
- Lubeluzole pretreatment does not provide neuroprotection against transient global cerebral ischemia in fetal sheep near term. Garnier, Y., Löbbert, T., Jensen, A., Berger, R. Pediatr. Res. (2002)
- Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. Lesage, A.S., Peeters, L., Leysen, J.E. J. Pharmacol. Exp. Ther. (1996)
- Lubeluzole attenuates K(+)-evoked extracellular accumulation of taurine in the striatum of healthy rats and rats with hepatic failure. Zielińska, M., Hilgier, W., Borkowska, H.D., Oja, S.S., Saransaari, P., Albrecht, J. Brain Res. (2001)
- Influence of lubeluzole on voltage-sensitive Ca++ channels in isolated rat neurons. Marrannes, R., De Prins, E., Clincke, G. J. Pharmacol. Exp. Ther. (1998)
- Effects of the neuroprotectant lubeluzole on the cytotoxic actions of veratridine, barium, ouabain and 6-hydroxydopamine in chromaffin cells. Cano-Abad, M.F., López, M.G., Hernández-Guijo, J.M., Zapater, P., Gandía, L., Sánchez-García, P., García, A.G. Br. J. Pharmacol. (1998)
- Safety and pharmacokinetics of the neuroprotective drug lubeluzole in patients with ischemic stroke. De Keyser, J., Van de Velde, V., Schellens, R.L., Hantson, L., Tritsmans, L., Gheuens, J., Van Peer, A., Woestenborghs, R., Franke, C.L., van Gorp, J. Clinical therapeutics. (1997)
- Effects of the antihypoxic and neuroprotective drug, lubeluzole, on repolarization phase of canine heart assessed by monophasic action potential recording. Sugiyama, A., Ni, C., Arita, J., Eto, K., Xue, Y.X., Hashimoto, K. Toxicol. Appl. Pharmacol. (1996)
- Differential effects of the neuroprotectant lubeluzole on bovine and mouse chromaffin cell calcium channel subtypes. Hernández-Guijo, J.M., Gandía, L., de Pascual, R., García, A.G. Br. J. Pharmacol. (1997)
- Treatment of experimental focal ischemia in rats with lubeluzole. Aronowski, J., Strong, R., Grotta, J.C. Neuropharmacology (1996)
- Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemia. Culmsee, C., Junker, V., Wolz, P., Semkova, I., Krieglstein, J. Eur. J. Pharmacol. (1998)
- Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats. Scheller, D.K., De Ryck, M., Kolb, J., Szathmary, S., van Reempts, J., Clincke, G., Tegtmeier, F. Eur. J. Pharmacol. (1997)
- Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole. Grotta, J. Cerebrovasc. Dis. (2001)
- Epileptiform discharges to extracellular stimuli in rat neocortical slices after photothrombotic infarction. Buchkremer-Ratzmann, I., August, M., Hagemann, G., Witte, O.W. J. Neurol. Sci. (1998)
- Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: effect of lubeluzole. De Ryck, M., Verhoye, M., Van der Linden, A.M. Neuropharmacology (2000)