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MeSH Review

Mammary Neoplasms, Animal

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Disease relevance of Mammary Neoplasms, Animal


High impact information on Mammary Neoplasms, Animal


Chemical compound and disease context of Mammary Neoplasms, Animal

  • Binding of fluorescein isothiocyanate conjugated lectins to MXT mouse mammary neoplasm and their relation to steroid receptor status [8].
  • 312C8-1 and 13H5 antibodies are specific for canine mammary basal and luminal epithelium, respectively, and by employing these antibodies, the origin and differentiation of canine mammary neoplasms can be determined more accurately than on the basis of hematoxylin and eosin-stained tissue alone [9].
  • The aim of the study was to evaluate the possible changes in the alpha 5 beta 1 integrin receptor and its ligand fibronectin in relation to the metastatic capacity of canine mammary neoplasms [10].

Biological context of Mammary Neoplasms, Animal

  • As previous studies have suggested a hormone dependence of binding sites for peanut agglutinin in mammary neoplasm, this feature has been thought to be correlated to steroid receptor status [8].
  • In conclusion, the expression and distribution of connexins and E-cadherin are inversely correlated to cell proliferation in malignant mammary neoplasms of dogs and may well be related to their more aggressive histologic type and biologic behavior [11].

Anatomical context of Mammary Neoplasms, Animal

  • Removal of an endogenous EGF stimulus by surgical ablation of the submaxillary glands, the major EGF-producing organ in mice, produced significantly slower growth of rodent mammary neoplasms, decreased success rate of transplantation, and an increase in the latent period before growth occurred [12].

Gene context of Mammary Neoplasms, Animal


  1. Endocrinology in cancer of the breast. Status and prospects. Brennan, M.J. Am. J. Clin. Pathol. (1975) [Pubmed]
  2. Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma. Acs, G., Zhang, P.J., Rebbeck, T.R., Acs, P., Verma, A. Cancer (2002) [Pubmed]
  3. Assessment of interaction among three carcinogens on rat mammary carcinogenesis in a factorially designed experiment. Shellabarger, C.J., Machado, S.G., Holtzman, S., Stone, J.P. J. Natl. Cancer Inst. (1987) [Pubmed]
  4. Induction of mammary neoplasms in the ACI rat by 430-keV neutrons, X-rays, and diethylstilbestrol. Shellabarger, C.J., Chmelevsky, D., Kellerer, A.M., Stone, J.P., Holtzman, S. J. Natl. Cancer Inst. (1982) [Pubmed]
  5. Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Kwan, H., Pecenka, V., Tsukamoto, A., Parslow, T.G., Guzman, R., Lin, T.P., Muller, W.J., Lee, F.S., Leder, P., Varmus, H.E. Mol. Cell. Biol. (1992) [Pubmed]
  6. Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours. Ahmad, P.M., Feltman, D.S., Ahmad, F. Biochem. J. (1982) [Pubmed]
  7. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. Gunson, D.E., Steele, R.E., Chau, R.Y. Br. J. Cancer (1995) [Pubmed]
  8. Binding of fluorescein isothiocyanate conjugated lectins to MXT mouse mammary neoplasm and their relation to steroid receptor status. Kiss, R., Lenglet, G., Danguy, A. Anticancer Res. (1986) [Pubmed]
  9. Immunohistochemical reactivity of basal and luminal epithelium-specific cytokeratin antibodies within normal and neoplastic canine mammary glands. Griffey, S.M., Madewell, B.R., Dairkee, S.H., Hunt, J.E., Naydan, D.K., Higgins, R.J. Vet. Pathol. (1993) [Pubmed]
  10. Expression of fibronectin and its integrin receptor alpha 5 beta 1 in canine mammary tumours. Peña, L., Nieto, A., Perez Alenza, M.D., Rodriguez, A., Sanchez, M.A., Castaño, M. Res. Vet. Sci. (1994) [Pubmed]
  11. Expression of connexins 26 and 43 in canine hyperplastic and neoplastic mammary glands. Torres, L.N., Matera, J.M., Vasconcellos, C.H., Avanzo, J.L., Hernandez-Blazquez, F.J., Dagli, M.L. Vet. Pathol. (2005) [Pubmed]
  12. Verhulstian analysis of the growth of transplantable mammary tumours in sialoadenectomized mice. Leith, J.T., Harrigan, P., Michelson, S. Cell Prolif. (1991) [Pubmed]
  13. Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands. Lee, J.L., Chang, C.J., Wu, S.Y., Sargan, D.R., Lin, C.T. Breast Cancer Res. Treat. (2004) [Pubmed]
  14. Prognostic status of p53 gene mutation in canine mammary carcinoma. Wakui, S., Muto, T., Yokoo, K., Yokoo, R., Takahashi, H., Masaoka, T., Hano, H., Furusato, M. Anticancer Res. (2001) [Pubmed]
  15. Evaluation of angiogenesis in canine mammary tumors by quantitative platelet endothelial cell adhesion molecule immunohistochemistry. Restucci, B., De Vico, G., Maiolino, P. Vet. Pathol. (2000) [Pubmed]
  16. Interleukin-2 alterations in the immune status of patients with mammary neoplasm. Blidaru, A., Bordea, C.I., Viişoreanu, C.G., Bordea, M., Iliescu, I., Duţescu, D., Radu, F., Drăgoescu, H. Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale]. (1998) [Pubmed]
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