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MeSH Review

Adrenocortical Hyperfunction

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Disease relevance of Adrenocortical Hyperfunction


Psychiatry related information on Adrenocortical Hyperfunction


High impact information on Adrenocortical Hyperfunction

  • Thus, besides polycystic ovaries, the bLHbeta-CTP mice provide a useful model for studying human disorders related to elevated LH secretion and adrenocortical hyperfunction [7].
  • LH receptor (LHR) expression and activity were also elevated in adrenals from female TG mice, but gonadectomized TG females showed no increase in corticosterone, suggesting that the dysfunctional ovaries of the intact TG females promote adrenocortical hyperfunction [7].
  • Physiologic doses of hydrocortisone induced hepatic TAT activity, but pair-weighed control animals with the same degree of hypercorticism as was found in tumor-bearing animals had normal TAT activity in liver tissue [8].
  • In conclusion, metabolic disturbances elicited by a type 2 diabetes syndrome (insulin and/or leptin resistance, but not hypercorticism) appear to suppress type 1 diabetes development in NOD-Lepr(db-5J)/Lt by inhibiting activation of T-effector cells [9].
  • ACTH-independent macronodular adrenal hyperplasia (AIMAH) is an uncommon cause of Cushing's syndrome characterized by bilateral nodular adrenocortical hyperfunction in the presence of suppressed ACTH levels [10].

Chemical compound and disease context of Adrenocortical Hyperfunction


Biological context of Adrenocortical Hyperfunction


Anatomical context of Adrenocortical Hyperfunction


Gene context of Adrenocortical Hyperfunction

  • It is concluded that continuous hyperstimulation of pituitary corticotropes with hypothalamic CRH is probably not the cause of excessive ACTH secretion in dogs with pituitary-dependent hyperadrenocorticism [20].
  • However, with regard to group II, the CRH-induced ACTH increase 1 week after selective adenomectomy indirectly supports the concept of CRH deficiency during hypercorticism and thus, in these patients as well as in group I, a pituitary origin of the disease [25].
  • (The nocturnal increment in plasma prolactin concentrations in these patients with hypercorticism compared with that of normal subjects was reduced, P less than .02) [26].
  • In pituitary-dependent hyperadrenocorticism (Cushing's disease), the disturbed regulation of ACTH secretion is associated with neoplastic transformation of corticotropic cells [27].
  • The aim of this study is to investigate the effects of ghrelin and GH-releasing peptide-6 (GHRP-6) on the release of growth hormone (GH), adrenocorticotrophic hormone (ACTH), and cortisol in dogs with pituitary-dependent hyperadrenocorticism (PDH) and in healthy dogs of comparable age [28].

Analytical, diagnostic and therapeutic context of Adrenocortical Hyperfunction


  1. Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice. Tanaka, Y., Eda, H., Tanaka, T., Udagawa, T., Ishikawa, T., Horii, I., Ishitsuka, H., Kataoka, T., Taguchi, T. Cancer Res. (1990) [Pubmed]
  2. Hypercortisolism and its possible neural bases. Sapolsky, R.M., Plotsky, P.M. Biol. Psychiatry (1990) [Pubmed]
  3. Anterior pituitary function after transsphenoidal selective adenomectomy in patients with Cushing's disease. Kuwayama, A., Kageyama, N., Nakane, T., Watanabe, M., Kanie, N. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  4. Alterations of local cerebral glucose utilization in lean and obese fa/fa rats after acute adrenalectomy. Doyle, P., Rohner-Jeanrenaud, F., Jeanrenaud, B. Brain Res. (1994) [Pubmed]
  5. Generalized demodicosis associated with diabetes mellitus in two cats. White, S.D., Carpenter, J.L., Moore, F.M., Ogilvie, G. J. Am. Vet. Med. Assoc. (1987) [Pubmed]
  6. Alzheimer's disease: pathophysiological implications of measurement of plasma cortisol, plasma dehydroepiandrosterone sulfate, and lymphocytic corticosteroid receptors. Armanini, D., Vecchio, F., Basso, A., Milone, F.F., Simoncini, M., Fiore, C., Mattarello, M.J., Sartorato, P., Karbowiak, I. Endocrine (2003) [Pubmed]
  7. Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex. Kero, J., Poutanen, M., Zhang, F.P., Rahman, N., McNicol, A.M., Nilson, J.H., Keri, R.A., Huhtaniemi, I.T. J. Clin. Invest. (2000) [Pubmed]
  8. Tumor-host wasting not explained by adrenal hyperfunction in tumor-bearing animals. Svaninger, G., Gelin, J., Lundholm, K. J. Natl. Cancer Inst. (1987) [Pubmed]
  9. Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis. Lee, C.H., Chen, Y.G., Chen, J., Reifsnyder, P.C., Serreze, D.V., Clare-Salzler, M., Rodriguez, M., Wasserfall, C., Atkinson, M.A., Leiter, E.H. Diabetes (2006) [Pubmed]
  10. Cushing's syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene. Fragoso, M.C., Domenice, S., Latronico, A.C., Martin, R.M., Pereira, M.A., Zerbini, M.C., Lucon, A.M., Mendonca, B.B. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  11. Twelve-hour cycles of adrenocorticotropin and cortisol secretion in Cushing's disease. Schteingart, D.E., McKenzie, A.K. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  12. Effects of chronic glucocorticoid excess in man on insulin binding to circulating cells: differences between endogenous and exogenous hypercorticism. Muggeo, M., Saviolakis, A., Wachslicht-Rodbard, H., Roth, J. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  13. Dual sites of inhibition by metyrapone of human adrenal steroidogenesis: correlation of in vivo and in vitro studies. Carballeira, A., Fishman, L.M., Jacobi, J.D. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  14. Serum dehydroepiandrosterone sulfate in Cushing's syndrome. Yamaji, T., Ishibashi, M., Sekihara, H., Itabashi, A., Yanaihara, T. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  15. Reduced fibrinolytic potential one year after kidney transplantation. Relationship to long-term steroid treatment. Patrassi, G.M., Sartori, M.T., Rigotti, P., Di Landro, D., Theodoridis, P., Fioretti, M., Capalbo, M., Saggiorato, G., Boeri, G., Girolami, A. Transplantation (1995) [Pubmed]
  16. Cortisol metabolism in chronic liver disease. McCann, V.J., Fulton, T.T. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  17. Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane. Donckier, J.E., Michel, L.A., Berbinschi, A., De Coster, P.M., De Plaen, J.F., Ketelslegers, J.M., Buysschaert, M. Surgery (1989) [Pubmed]
  18. Osmoregulation of systemic vasopressin release during long-term glucocorticoid excess: a study in dogs with hyperadrenocorticism. Biewenga, W.J., Rijnberk, A., Mol, J.A. Acta Endocrinol. (1991) [Pubmed]
  19. Captopril in Cushing's syndrome. Greminger, P., Vetter, W., Groth, H., Lüscher, T., Tenschert, W., Siegenthaler, W., Vetter, H. Klin. Wochenschr. (1984) [Pubmed]
  20. Corticotropin-releasing hormone and adrenocorticotropic hormone concentrations in cerebrospinal fluid of dogs with pituitary-dependent hyperadrenocorticism. Van Wijk, P.A., Rijnberk, A., Croughs, R.J., Voorhout, G., Sprang, E.P., Mol, J.A. Endocrinology (1992) [Pubmed]
  21. RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient beta-adrenergic signalling in adipocytes from mature C57BL/6J-ob/ob mice. Gettys, T.W., Watson, P.M., Taylor, I.L., Collins, S. Int. J. Obes. Relat. Metab. Disord. (1997) [Pubmed]
  22. The effect of experimental hyperthyroidism on renal and adrenal weight increase in mice. Broulík, P.D., Marek, J., Schreiber, V. Physiological research / Academia Scientiarum Bohemoslovaca. (1991) [Pubmed]
  23. A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog. Lee, Y.M., Kang, B.T., Jung, D.I., Park, C., Kim, H.J., Kim, J.W., Lim, C.Y., Park, E.H., Park, H.M. J. Vet. Sci. (2005) [Pubmed]
  24. Cytochemical and ultracytochemical studies of peroxidase activity in rabbit blood granulocytes under hydrocortisone effect. Zak, K.P., Filatova, R.S., Afanasyeva, V.V. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. (1983) [Pubmed]
  25. Corticotropin-releasing hormone stimulation test before and after transsphenoidal selective microadenomectomy in 30 patients with Cushing's disease. Schrell, U., Fahlbusch, R., Buchfelder, M., Riedl, S., Stalla, G.K., Müller, O.A. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  26. Absence of nocturnal elevation of plasma prolactin concentrations in Cushing's disease. Krieger, D.T., Howanitz, P.J., Frantz, A.G. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  27. Proliferation of the murine corticotropic tumour cell line AtT20 is affected by hypophysiotrophic hormones, growth factors and glucocorticoids. van Wijk, P.A., van Neck, J.W., Rijnberk, A., Croughs, R.J., Mol, J.A. Mol. Cell. Endocrinol. (1995) [Pubmed]
  28. Effects of growth hormone-releasing peptides in healthy dogs and in dogs with pituitary-dependent hyperadrenocorticism. Bhatti, S.F., De Vliegher, S.P., Van Ham, L., Kooistra, H.S. Mol. Cell. Endocrinol. (2002) [Pubmed]
  29. Biochemical characterization of pituitary-dependent hyperadrenocorticism in the dog. Meijer, J.C., de Bruijne, J.J., Rijnberk, A., Croughs, R.J. J. Endocrinol. (1978) [Pubmed]
  30. Efficacy of cobalt 60 radiotherapy in dogs with pituitary-dependent hyperadrenocorticism. Goossens, M.M., Feldman, E.C., Theon, A.P., Koblik, P.D. J. Am. Vet. Med. Assoc. (1998) [Pubmed]
  31. Secretion of sex hormones in dogs with adrenal dysfunction. Hill, K.E., Scott-Moncrieff, J.C., Koshko, M.A., Glickman, L.T., Glickman, N.W., Nelson, R.W., Blevins, W.E., Oliver, J.W. J. Am. Vet. Med. Assoc. (2005) [Pubmed]
  32. Non-dexamethasone-suppressible, pituitary-dependent hyperadrenocorticism in a dog. Kemppainen, R.J., Zenoble, R.D. J. Am. Vet. Med. Assoc. (1985) [Pubmed]
  33. A retrospective study of aldosterone secretion in normal and adrenopathic dogs. Golden, D.L., Lothrop, C.D. J. Vet. Intern. Med. (1988) [Pubmed]
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