Disease relevance of Contact Lenses, Hydrophilic

• The authors determined the attachment of a single strain of Pseudomonas aeruginosa to seven brands of hydrogel soft contact lenses (SCLs): nonionic, low-water (polymacon and crofilcon); nonionic, high-water (lidofilcon); ionic, high-water (bufilcon, etafilcon, and perfilcon); and surface-neutralized, high-water (bufilcon) [1].
• Delayed hypersensitivity to thimerosal in soft contact lens wearers [2].
• Postoperative pain management included patching and oral analgesics in 77 eyes and the use of topical diclofenac or ketorolac and a therapeutic soft contact lens in 163 eyes [3].
• Three male and two female patients (aged 16 to 22 years) developed bilateral deep corneal stromal vascularization and circinate-pattern lipid exudation resembling interstitial keratitis after wearing adequately fitting hydrogel daily wear soft contact lenses comfortably for periods of ten to 24 months [4].
• Patients with delayed hypersensitivity to thimerosal may develop conjunctival hyperemia, corneal infiltrates and intolerance to lens wear with the use of soft contact lens solutions containing thimerosal [5].

High impact information on Contact Lenses, Hydrophilic

• PURPOSE: Extended wear of conventional hydrogel soft contact lenses (SCLs) is associated with adverse ocular responses [6].
• CONCLUSIONS: In this database of soft contact lens wearers, myopia progression was common for subjects in their twenties and less common for those in their thirties [7].
• Analysis of glycoprotein deposits on disposable soft contact lenses [8].
• Isolation and identification of biologically active contaminants from soft contact lenses. I. Nicotine deposits on worn lenses [9].
• A rapid fluorescent staining method using a tetrazolium dye and propidium iodide for the in-use assessment of disinfection of Pseudomonas aeruginosa biofilms on soft contact lenses showed that 11 to 13% of cells on lenses remained actively respiring and recoverable by culture methods after 30 min of exposure to 3% hydrogen peroxide [10].

Chemical compound and disease context of Contact Lenses, Hydrophilic

• Nonmucoid Pseudomonas aeruginosa isolated from corneal ulcers and contact lens cases and solutions were examined for their ability to adhere to polystyrene, glass, and hydrophilic contact lenses of varying water content and polymer composition [11].
• In four cases, fungal growth on and in the soft contact lens matrix was associated with conjunctivitis and punctate fluorescein staining of the corneal epithelium [12].
• Seven Pseudomonas corneal ulcers in six patients were associated with soft contact-lens wear and use of saline solutions prepared from distilled water and sodium chloride tablets [13].
• The advantages and disadvantages of the newly introduced Plano-T soft contact lens for the treatment of corneal diseases were evaluated [14].
• The symptoms and signs gradually subsided after discontinued use of soft contact lens and application of topical steroid [15].

Biological context of Contact Lenses, Hydrophilic

• Large cells were observed in diabetic aphakic patients, aphakic extended-wear soft contact lens wearers, and aphakic patients using 0.5% indomethacin eye drops; thus, the presence of large cells may indicate suppressed metabolism and mitosis [16].
• Chlorhexidine kinetics of hydrophilic contact lenses [17].
• Forward-scattered light, back-scattered light, and visual acuity were investigated and data were collected from 35 myopic individuals with various types of correction for myopia (spectacles, hard and soft contact lenses, and excimer laser surgery) [18].
• PURPOSE: To determine whether the regulators of complement activation, decay-accelerating factor (DAF) and CD59, which have been identified on the cornea and conjunctiva and in soluble forms in tears and lacrimal secretions, are transferred to soft contact lenses worn by normal subjects [19].
• PURPOSE: To investigate the effects of daily wear opaquely tinted hydrogel soft contact lenses on contrast sensitivity functions, as measured using the Pelli-Robson chart viewed at 1 meter [20].

Anatomical context of Contact Lenses, Hydrophilic

• Collagen corneal shields allowed a significant (P less than .05) increase in tobramycin penetration into the anterior chamber at 60 minutes compared with hydrophilic soft contact lenses or controls [21].
• Therefore, ammonia gaseous plasma modification technique was used to modify the surface chemical properties of soft contact lens material such as poly(2-hydroxyethyl methacrylate and methacrylic acid), PHEMA-MAA copolymer, in an attempt to enhance the cell attachment and growth of rabbit corneal epithelial cells [22].
• The purpose of this study was to compare and evaluate the penetration of amikacin sulfate into aqueous humor of the rabbit eye when applied by different routes and concentrations, namely 100 or 250 mg/ml topical fortified amikacin eye drops, 100 or 250 mg/ml amikacin-embedded soft contact lenses and 25 mg subconjunctival amikacin injection [23].
• Three soft contact lenses of the HEMA type, discarded because of irritation of the cornea, were processed for and subsequently examined with the SEM, A large portion of the convex surface was covered with globular deposits of fungal spores [24].
• CONCLUSION: In this patient with partial limbal stem cell deficiency secondary to soft contact lens wear, LASIK was a viable and safe alternative for the correction of myopia [25].

Associations of Contact Lenses, Hydrophilic with chemical compounds

• The effects of long-term extended wear of soft contact lenses on the human cornea were determined by examining 27 patients who had worn a high water content hydrogel contact lens in 1 eye only for an average of 62 +/- 29 months (mean +/- SD) [26].
• Therefore, selective adherence by P. aeruginosa to a specific sugar (sialic acid) may be important in the initial attachment of the bacterium to soft contact lenses [27].
• Six wore daily wear soft contact lenses, two wore extended-wear soft contact lenses, one wore a polymethylmethacrylate hard contact lens, one wore a gas-permeable hard contact lens, and one wore a Saturn lens (combined hard and soft lens) [28].
• We examined 38 patients who were using soft contact lenses and found that 31 patients had positive ocular provocation test results to a thimerosal-preserved artificial tears solution [29].
• Two methods are described for the analysis of chlorhexidine sorption in soft contact lenses [30].

Gene context of Contact Lenses, Hydrophilic

• METHODS: Following overnight wear of group 4 extended-wear hydrophilic contact lenses by five normal subjects, we examined the lenses immunohistochemically for decay-accelerating factor (DAF) and CD59, two regulators which interfere with the complement cascade at the C3 and C9 steps, respectively [19].
• Protein adsorption on soft contact lenses. III. Mucin [31].
• Lysozyme was adsorbed on spin cast and lathe cut soft contact lenses of poly-2-hydroxyethylmethacrylate (PHEMA) and on poly-HEMA-methacrylic acid (PHEMA/MAA) [32].
• The tears of soft contact lens wearers (wearing lenses on an extended were schedule) were analysed for the amount of fibronectin, albumin and total protein [33].
• Granular corneal dystrophy: treatment with soft contact lenses [34].

Analytical, diagnostic and therapeutic context of Contact Lenses, Hydrophilic

• Analysis of chlorhexidine sorption in soft contact lenses by catalytic oxidation of [14C]chlorhexidine and by liquid chromatography [30].
• OBJECTIVE: To compare the effects of rigid gas-permeable contact lenses (RGPs) and soft contact lenses (SCLs) on myopia progression in children [35].
• PURPOSE: To evaluate contrast vision and glare sensitivity under mesopic conditions in eyes having uncomplicated excimer laser photorefractive keratectomy (PRK) for myopia and in eyes corrected by disposable soft contact lenses, soft contact lenses, and spectacles [36].
• The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems [37].
• The surface of soft contact lenses made of crosslinked poly(2-hydroxyethyl methacrylate). pHEMA, has been investigated with atomic force microscopy in contact mode [38].

References