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Disease relevance of Craniopharyngioma


Psychiatry related information on Craniopharyngioma

  • A 48-year-old man with a cystic craniopharyngioma developed hypersomnia, personality changes, memory impairment and thermal dysfunction following intracystic administration of bleomycin through an Ommaya reservoir after partial removal of the tumour [6].

High impact information on Craniopharyngioma

  • We studied insulin-like growth factors (IGF) I and II, prolactin, and the insulin response to arginine in 19 children with craniopharyngioma and documented growth hormone deficiency [7].
  • We have reported previously that alterations to beta-catenin occur frequently in adamantinomatous craniopharyngioma [8].
  • Baseline characteristics and response to 2 years of growth hormone (GH) replacement of hypopituitary patients with GH deficiency due to adult-onset craniopharyngioma in comparison with patients with nonfunctioning pituitary adenoma: data from KIMS (Pfizer International Metabolic Database) [9].
  • Relevant decreases in height sd score (SDS) started at 10-12 months of age and persisted until diagnosis of childhood craniopharyngioma [10].
  • Defect in epinephrine production in children with craniopharyngioma: functional or organic origin [11]?

Chemical compound and disease context of Craniopharyngioma


Biological context of Craniopharyngioma


Anatomical context of Craniopharyngioma


Gene context of Craniopharyngioma


Analytical, diagnostic and therapeutic context of Craniopharyngioma


  1. Recurrent fever of unknown origin, coma, and meningismus due to a leaking craniopharyngioma. Krueger, D.W., Larson, E.B. Am. J. Med. (1988) [Pubmed]
  2. Hyperprolactinemia is associated with increased immunoreactive somatomedin C in hypopituitarism. Clemmons, D.R., Underwood, L.E., Ridgway, E.C., Kliman, B., Van Wyk, J.J. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  3. Galactorrhea, oligo/amenorrhea, and hyperprolactinemia in patients with craniopharyngiomas. Kapcala, L.P., Molitch, M.E., Post, K.D., Biller, B.J., Prager, R.J., Jackson, I.M., Reichlin, S. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  4. Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. Müller, H.L., Handwerker, G., Wollny, B., Faldum, A., Sörensen, N. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  5. Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma. Goldstone, A.P., Patterson, M., Kalingag, N., Ghatei, M.A., Brynes, A.E., Bloom, S.R., Grossman, A.B., Korbonits, M. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  6. Toxic effects of bleomycin on the hypothalamus following its administration into a cystic craniopharyngioma. Haisa, T., Ueki, K., Yoshida, S. British journal of neurosurgery. (1994) [Pubmed]
  7. Insulin-like growth factors I and II, prolactin, and insulin in 19 growth hormone-deficient children with excessive, normal, or decreased longitudinal growth after operation for craniopharyngioma. Bucher, H., Zapf, J., Torresani, T., Prader, A., Froesch, E.R., Illig, R. N. Engl. J. Med. (1983) [Pubmed]
  8. Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas. Sekine, S., Sato, S., Takata, T., Fukuda, Y., Ishida, T., Kishino, M., Shibata, T., Kanai, Y., Hirohashi, S. Am. J. Pathol. (2003) [Pubmed]
  9. Baseline characteristics and response to 2 years of growth hormone (GH) replacement of hypopituitary patients with GH deficiency due to adult-onset craniopharyngioma in comparison with patients with nonfunctioning pituitary adenoma: data from KIMS (Pfizer International Metabolic Database). Verhelst, J., Kendall-Taylor, P., Erfurth, E.M., Price, D.A., Geffner, M., Koltowska-Häggström, M., Jönsson, P.J., Wilton, P., Abs, R. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  10. Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. Müller, H.L., Emser, A., Faldum, A., Bruhnken, G., Etavard-Gorris, N., Gebhardt, U., Oeverink, R., Kolb, R., Sörensen, N. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  11. Defect in epinephrine production in children with craniopharyngioma: functional or organic origin? Coutant, R., Maurey, H., Rouleau, S., Mathieu, E., Mercier, P., Limal, J.M., Le Bouil, A. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  12. Organ culture of craniopharyngioma and its cellular effects induced by colloidal chromic phosphate. Young, H.F., Fu, Y.S., Fratkin, M.J. J. Neuropathol. Exp. Neurol. (1976) [Pubmed]
  13. Craniopharyngioma: the role of insulin in promoting postoperative growth. Costin, G., Kogut, M.D., Phillips, L.S., Daughaday, W.H. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  14. Characterization of the levels of expression of retinoic acid receptors, galectin-3, macrophage migration inhibiting factor, and p53 in 51 adamantinomatous craniopharyngiomas. Lefranc, F., Chevalier, C., Vinchon, M., Dhellemmes, P., Schüring, M.P., Kaltner, H., Brotchi, J., Ruchoux, M.M., Gabius, H.J., Salmon, I., Kiss, R. J. Neurosurg. (2003) [Pubmed]
  15. Progesterone receptor gene expression in craniopharyngiomas and evidence for biological activity. Honegger, J., Renner, C., Fahlbusch, R., Adams, E.F. Neurosurgery (1997) [Pubmed]
  16. Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas. Buslei, R., Kreutzer, J., Hofmann, B., Schmidt, V., Siebzehnrübl, F., Hahnen, E., Eyupoglu, I.Y., Fahlbusch, R., Blümcke, I. Acta Neuropathol. (2006) [Pubmed]
  17. Mutation in exon 7 of PTCH deregulates SHH/PTCH/SMO signaling: possible linkage to WNT. Musani, V., Gorry, P., Basta-Juzbasic, A., Stipic, T., Miklic, P., Levanat, S. Int. J. Mol. Med. (2006) [Pubmed]
  18. Growth without growth hormone. Phillip, M., Moran, O., Lazar, L. Journal of pediatric endocrinology & metabolism : JPEM. (2002) [Pubmed]
  19. GHRH plus arginine in the diagnosis of acquired GH deficiency of childhood-onset. Maghnie, M., Cavigioli, F., Tinelli, C., Autelli, M., Aricò, M., Aimaretti, G., Ghigo, E. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  20. The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Mason, P.W., Krawiecki, N., Meacham, L.R. Archives of pediatrics & adolescent medicine. (2002) [Pubmed]
  21. Homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular CSF of comatose patients with obstructive hydrocephalus. Inagawa, T., Ishikawa, S., Uozumi, T. J. Neurosurg. (1980) [Pubmed]
  22. Immunohistochemical expression of human chorionic gonadotropin and P-glycoprotein in human pituitary glands and craniopharyngiomas. Tachibana, O., Yamashima, T., Yamashita, J., Takabatake, Y. J. Neurosurg. (1994) [Pubmed]
  23. Tenascin-C expression in the cyst wall and fluid of human brain tumors correlates with angiogenesis. Jallo, G.I., Friedlander, D.R., Kelly, P.J., Wisoff, J.H., Grumet, M., Zagzag, D. Neurosurgery (1997) [Pubmed]
  24. Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation. Sekine, S., Takata, T., Shibata, T., Mori, M., Morishita, Y., Noguchi, M., Uchida, T., Kanai, Y., Hirohashi, S. Histopathology (2004) [Pubmed]
  25. Differential expression of cytokeratins 8 and 20 distinguishes craniopharyngioma from rathke cleft cyst. Xin, W., Rubin, M.A., McKeever, P.E. Arch. Pathol. Lab. Med. (2002) [Pubmed]
  26. Angiogenesis in patients with craniopharyngiomas: correlation with treatment and outcome. Vidal, S., Kovacs, K., Lloyd, R.V., Meyer, F.B., Scheithauer, B.W. Cancer (2002) [Pubmed]
  27. Immunohistochemical detection of female sex hormone receptors in craniopharyngiomas: correlation with clinical and histologic features. Izumoto, S., Suzuki, T., Kinoshita, M., Hashiba, T., Kagawa, N., Wada, K., Fujimoto, Y., Hashimoto, N., Saitoh, Y., Maruno, M., Yoshimine, T. Surgical neurology. (2005) [Pubmed]
  28. Fatal toxic effect of bleomycin on brain tissue after intracystic chemotherapy for a craniopharyngioma: case report. Savas, A., Erdem, A., Tun, K., Kanpolat, Y. Neurosurgery (2000) [Pubmed]
  29. Intracavitary brachytherapy of cystic craniopharyngiomas. Van den Berge, J.H., Blaauw, G., Breeman, W.A., Rahmy, A., Wijngaarde, R. J. Neurosurg. (1992) [Pubmed]
  30. The syndrome of inappropriate secretion of antidiuretic hormone: an unusual presentation for childhood craniopharyngioma: report of three cases. Gonzales-Portillo, G., Tomita, T. Neurosurgery (1998) [Pubmed]
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